Acetylcholinesterase inhibition ameliorates deficits in motivational drive
<p>Abstract</p> <p>Background</p> <p>Apathy is frequently observed in numerous neurological disorders, including Alzheimer's and Parkinson's, as well as neuropsychiatric disorders including schizophrenia. Apathy is defined as a lack of motivation characterized...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2012-03-01
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| Series: | Behavioral and Brain Functions |
| Subjects: | |
| Online Access: | http://www.behavioralandbrainfunctions.com/content/8/1/15 |
| _version_ | 1818347761608687616 |
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| author | Martinowich Keri Cardinale Kathleen M Schloesser Robert J Hsu Michael Greig Nigel H Manji Husseini K |
| author_facet | Martinowich Keri Cardinale Kathleen M Schloesser Robert J Hsu Michael Greig Nigel H Manji Husseini K |
| author_sort | Martinowich Keri |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Apathy is frequently observed in numerous neurological disorders, including Alzheimer's and Parkinson's, as well as neuropsychiatric disorders including schizophrenia. Apathy is defined as a lack of motivation characterized by diminished goal-oriented behavior and self-initiated activity. This study evaluated a chronic restraint stress (CRS) protocol in modeling apathetic behavior, and determined whether administration of an anticholinesterase had utility in attenuating CRS-induced phenotypes.</p> <p>Methods</p> <p>We assessed behavior as well as regional neuronal activity patterns using FosB immunohistochemistry after exposure to CRS for 6 h/d for a minimum of 21 d. Based on our FosB findings and recent clinical trials, we administered an anticholinesterase to evaluate attenuation of CRS-induced phenotypes.</p> <p>Results</p> <p>CRS resulted in behaviors that reflect motivational loss and diminished emotional responsiveness. CRS-exposed mice showed differences in FosB accumulation, including changes in the cholinergic basal forebrain system. Facilitating cholinergic signaling ameliorated CRS-induced deficits in initiation and motivational drive and rescued immediate early gene activation in the medial septum and nucleus accumbens.</p> <p>Conclusions</p> <p>Some CRS protocols may be useful for studying deficits in motivation and apathetic behavior. Amelioration of CRS-induced behaviors with an anticholinesterase supports a role for the cholinergic system in remediation of deficits in motivational drive.</p> |
| first_indexed | 2024-12-13T17:39:18Z |
| format | Article |
| id | doaj.art-04abae4026104b97a3df5a2e15c35855 |
| institution | Directory Open Access Journal |
| issn | 1744-9081 |
| language | English |
| last_indexed | 2024-12-13T17:39:18Z |
| publishDate | 2012-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Behavioral and Brain Functions |
| spelling | doaj.art-04abae4026104b97a3df5a2e15c358552022-12-21T23:36:50ZengBMCBehavioral and Brain Functions1744-90812012-03-01811510.1186/1744-9081-8-15Acetylcholinesterase inhibition ameliorates deficits in motivational driveMartinowich KeriCardinale Kathleen MSchloesser Robert JHsu MichaelGreig Nigel HManji Husseini K<p>Abstract</p> <p>Background</p> <p>Apathy is frequently observed in numerous neurological disorders, including Alzheimer's and Parkinson's, as well as neuropsychiatric disorders including schizophrenia. Apathy is defined as a lack of motivation characterized by diminished goal-oriented behavior and self-initiated activity. This study evaluated a chronic restraint stress (CRS) protocol in modeling apathetic behavior, and determined whether administration of an anticholinesterase had utility in attenuating CRS-induced phenotypes.</p> <p>Methods</p> <p>We assessed behavior as well as regional neuronal activity patterns using FosB immunohistochemistry after exposure to CRS for 6 h/d for a minimum of 21 d. Based on our FosB findings and recent clinical trials, we administered an anticholinesterase to evaluate attenuation of CRS-induced phenotypes.</p> <p>Results</p> <p>CRS resulted in behaviors that reflect motivational loss and diminished emotional responsiveness. CRS-exposed mice showed differences in FosB accumulation, including changes in the cholinergic basal forebrain system. Facilitating cholinergic signaling ameliorated CRS-induced deficits in initiation and motivational drive and rescued immediate early gene activation in the medial septum and nucleus accumbens.</p> <p>Conclusions</p> <p>Some CRS protocols may be useful for studying deficits in motivation and apathetic behavior. Amelioration of CRS-induced behaviors with an anticholinesterase supports a role for the cholinergic system in remediation of deficits in motivational drive.</p>http://www.behavioralandbrainfunctions.com/content/8/1/15ApathyMotivationChronic stressCholinergicFosBc-fosNucleus accumbensBasal forebrain |
| spellingShingle | Martinowich Keri Cardinale Kathleen M Schloesser Robert J Hsu Michael Greig Nigel H Manji Husseini K Acetylcholinesterase inhibition ameliorates deficits in motivational drive Behavioral and Brain Functions Apathy Motivation Chronic stress Cholinergic FosB c-fos Nucleus accumbens Basal forebrain |
| title | Acetylcholinesterase inhibition ameliorates deficits in motivational drive |
| title_full | Acetylcholinesterase inhibition ameliorates deficits in motivational drive |
| title_fullStr | Acetylcholinesterase inhibition ameliorates deficits in motivational drive |
| title_full_unstemmed | Acetylcholinesterase inhibition ameliorates deficits in motivational drive |
| title_short | Acetylcholinesterase inhibition ameliorates deficits in motivational drive |
| title_sort | acetylcholinesterase inhibition ameliorates deficits in motivational drive |
| topic | Apathy Motivation Chronic stress Cholinergic FosB c-fos Nucleus accumbens Basal forebrain |
| url | http://www.behavioralandbrainfunctions.com/content/8/1/15 |
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