Acetylcholinesterase inhibition ameliorates deficits in motivational drive

Acetylcholinesterase inhibition ameliorates deficits in motivational drive

<p>Abstract</p> <p>Background</p> <p>Apathy is frequently observed in numerous neurological disorders, including Alzheimer's and Parkinson's, as well as neuropsychiatric disorders including schizophrenia. Apathy is defined as a lack of motivation characterized...

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Bibliographic Details
Main Authors: Martinowich Keri, Cardinale Kathleen M, Schloesser Robert J, Hsu Michael, Greig Nigel H, Manji Husseini K
Format: Article
Language:English
Published: BMC 2012-03-01
Series:Behavioral and Brain Functions
Subjects:
Apathy
Motivation
Chronic stress
Cholinergic
FosB
c-fos
Nucleus accumbens
Basal forebrain
Online Access:http://www.behavioralandbrainfunctions.com/content/8/1/15

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