DIAGNOSIS AND PREVENTION OF CARDIOTOXICITY IN PATIENTS WITH BREAST CANCER FROM THE STANDPOINT OF AN ONCOLOGIST AND A CARDIOLOGIST
Knowledge of anthracycline antibiotics’ (AAs) pathogenesis and main risk factors allowed to develop various methods of prevention and early detection of cardiotoxicity as well as to create several guidelines on decreasing the risk of its development. Traditional AAs are a crucial option in treatment...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | Russian |
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ABV-press
2017-09-01
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| Series: | Опухоли женской репродуктивной системы |
| Subjects: | |
| Online Access: | https://ojrs.abvpress.ru/ojrs/article/view/548 |
| _version_ | 1826557252854611968 |
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| author | T. Yu. Semiglazova G. M. Teletaeva N. A. Kozyavin A. V. Zagatina |
| author_facet | T. Yu. Semiglazova G. M. Teletaeva N. A. Kozyavin A. V. Zagatina |
| author_sort | T. Yu. Semiglazova |
| collection | DOAJ |
| description | Knowledge of anthracycline antibiotics’ (AAs) pathogenesis and main risk factors allowed to develop various methods of prevention and early detection of cardiotoxicity as well as to create several guidelines on decreasing the risk of its development. Traditional AAs are a crucial option in treatment of metastatic breast cancer including their repeated prescription. However, their application is significantly limited by various manifestations of toxicity, especially cumulative cardiotoxicity. The most promising is use of pegylated liposomal pharmaceutical formulations of AAs. Among these formulations, pegylated liposomal doxorubicin almost fully lacks anthracycline cardiotoxicity because due to its unique formulation it accumulates almost exclusively in tumor tissue. |
| first_indexed | 2024-04-10T01:56:04Z |
| format | Article |
| id | doaj.art-04ad606a2b924b988d924a4afe9bdcd9 |
| institution | Directory Open Access Journal |
| issn | 1994-4098 1999-8627 |
| language | Russian |
| last_indexed | 2025-03-14T08:25:39Z |
| publishDate | 2017-09-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Опухоли женской репродуктивной системы |
| spelling | doaj.art-04ad606a2b924b988d924a4afe9bdcd92025-03-02T13:05:34ZrusABV-pressОпухоли женской репродуктивной системы1994-40981999-86272017-09-01133172710.17650/1994-4098-2017-13-3-17-27543DIAGNOSIS AND PREVENTION OF CARDIOTOXICITY IN PATIENTS WITH BREAST CANCER FROM THE STANDPOINT OF AN ONCOLOGIST AND A CARDIOLOGISTT. Yu. Semiglazova0G. M. Teletaeva1N. A. Kozyavin2A. V. Zagatina3N.N. Petrov National Medical Research Oncology Center, Ministry of Health of Russia; North-Western State Medical University named after I. I. Mechnikov, Ministry of Health of RussiaN.N. Petrov National Medical Research Oncology Center, Ministry of Health of RussiaN.N. Petrov National Medical Research Oncology Center, Ministry of Health of RussiaMedica ClinicKnowledge of anthracycline antibiotics’ (AAs) pathogenesis and main risk factors allowed to develop various methods of prevention and early detection of cardiotoxicity as well as to create several guidelines on decreasing the risk of its development. Traditional AAs are a crucial option in treatment of metastatic breast cancer including their repeated prescription. However, their application is significantly limited by various manifestations of toxicity, especially cumulative cardiotoxicity. The most promising is use of pegylated liposomal pharmaceutical formulations of AAs. Among these formulations, pegylated liposomal doxorubicin almost fully lacks anthracycline cardiotoxicity because due to its unique formulation it accumulates almost exclusively in tumor tissue.https://ojrs.abvpress.ru/ojrs/article/view/548metastatic breast cancercardiotoxicityrisk factorsanthracycline antibioticspegylated liposomal doxorubicin |
| spellingShingle | T. Yu. Semiglazova G. M. Teletaeva N. A. Kozyavin A. V. Zagatina DIAGNOSIS AND PREVENTION OF CARDIOTOXICITY IN PATIENTS WITH BREAST CANCER FROM THE STANDPOINT OF AN ONCOLOGIST AND A CARDIOLOGIST Опухоли женской репродуктивной системы metastatic breast cancer cardiotoxicity risk factors anthracycline antibiotics pegylated liposomal doxorubicin |
| title | DIAGNOSIS AND PREVENTION OF CARDIOTOXICITY IN PATIENTS WITH BREAST CANCER FROM THE STANDPOINT OF AN ONCOLOGIST AND A CARDIOLOGIST |
| title_full | DIAGNOSIS AND PREVENTION OF CARDIOTOXICITY IN PATIENTS WITH BREAST CANCER FROM THE STANDPOINT OF AN ONCOLOGIST AND A CARDIOLOGIST |
| title_fullStr | DIAGNOSIS AND PREVENTION OF CARDIOTOXICITY IN PATIENTS WITH BREAST CANCER FROM THE STANDPOINT OF AN ONCOLOGIST AND A CARDIOLOGIST |
| title_full_unstemmed | DIAGNOSIS AND PREVENTION OF CARDIOTOXICITY IN PATIENTS WITH BREAST CANCER FROM THE STANDPOINT OF AN ONCOLOGIST AND A CARDIOLOGIST |
| title_short | DIAGNOSIS AND PREVENTION OF CARDIOTOXICITY IN PATIENTS WITH BREAST CANCER FROM THE STANDPOINT OF AN ONCOLOGIST AND A CARDIOLOGIST |
| title_sort | diagnosis and prevention of cardiotoxicity in patients with breast cancer from the standpoint of an oncologist and a cardiologist |
| topic | metastatic breast cancer cardiotoxicity risk factors anthracycline antibiotics pegylated liposomal doxorubicin |
| url | https://ojrs.abvpress.ru/ojrs/article/view/548 |
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