Excessive exercise induces cardiac arrhythmia in a young fibromyalgia mouse model.
<h4>Background</h4>Fibromyalgia patients experience cardiovascular complications in addition to musculoskeletal pain. This study aimed to investigate the cardiac effects of a prolonged shallow water gait in a fibromyalgia-induced young mouse model.<h4>Methods</h4>To produce a...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2020-01-01
|
| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0239473 |
| _version_ | 1818400911299444736 |
|---|---|
| author | Taiki Nakata Atsushi Doi Daisuke Uta Megumu Yoshimura Min-Chul Shin |
| author_facet | Taiki Nakata Atsushi Doi Daisuke Uta Megumu Yoshimura Min-Chul Shin |
| author_sort | Taiki Nakata |
| collection | DOAJ |
| description | <h4>Background</h4>Fibromyalgia patients experience cardiovascular complications in addition to musculoskeletal pain. This study aimed to investigate the cardiac effects of a prolonged shallow water gait in a fibromyalgia-induced young mouse model.<h4>Methods</h4>To produce a fibromyalgia mouse model, wild-type mice were administered an intraperitoneal injection of reserpine once a day for three days, and two primary experiments were performed. First, three types of gait tests were performed before and after the reserpine injections as follows: (i) 5 minutes of free gait outside the water, (ii) 1 minute of free gait in shallow warm water, and (iii) 5 minutes of free gait in shallow warm water. Second, electrocardiogram recordings were taken before and after the three gait tests. The average heart rate and heart rate irregularity scores were analyzed.<h4>Results</h4>Exercise-induced cardiac arrhythmia was observed at 1-minute gait in shallow water during the acute stage of induced FM in young mice. Further, both cardiac arrhythmia and a decrease in HR have occurred at 5-minute gait in shallow water at the same mice. However, this phenomenon was not observed in the wild-type mice under any test conditions.<h4>Conclusion</h4>Although a short-term free gait in shallow warm water may be advantageous for increasing the motor activity of FM-model mice, we should be aware of the risk of prolonged and excessive exercise-induced cardiac arrhythmia. For gait exercises in shallow water as a treatment in FM patients. We suggest a gradual increase in exercise duration may be warranted. |
| first_indexed | 2024-12-14T07:44:06Z |
| format | Article |
| id | doaj.art-04adebb6447943ddb347dc8813a07e26 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-14T07:44:06Z |
| publishDate | 2020-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-04adebb6447943ddb347dc8813a07e262022-12-21T23:10:56ZengPublic Library of Science (PLoS)PLoS ONE1932-62032020-01-01159e023947310.1371/journal.pone.0239473Excessive exercise induces cardiac arrhythmia in a young fibromyalgia mouse model.Taiki NakataAtsushi DoiDaisuke UtaMegumu YoshimuraMin-Chul Shin<h4>Background</h4>Fibromyalgia patients experience cardiovascular complications in addition to musculoskeletal pain. This study aimed to investigate the cardiac effects of a prolonged shallow water gait in a fibromyalgia-induced young mouse model.<h4>Methods</h4>To produce a fibromyalgia mouse model, wild-type mice were administered an intraperitoneal injection of reserpine once a day for three days, and two primary experiments were performed. First, three types of gait tests were performed before and after the reserpine injections as follows: (i) 5 minutes of free gait outside the water, (ii) 1 minute of free gait in shallow warm water, and (iii) 5 minutes of free gait in shallow warm water. Second, electrocardiogram recordings were taken before and after the three gait tests. The average heart rate and heart rate irregularity scores were analyzed.<h4>Results</h4>Exercise-induced cardiac arrhythmia was observed at 1-minute gait in shallow water during the acute stage of induced FM in young mice. Further, both cardiac arrhythmia and a decrease in HR have occurred at 5-minute gait in shallow water at the same mice. However, this phenomenon was not observed in the wild-type mice under any test conditions.<h4>Conclusion</h4>Although a short-term free gait in shallow warm water may be advantageous for increasing the motor activity of FM-model mice, we should be aware of the risk of prolonged and excessive exercise-induced cardiac arrhythmia. For gait exercises in shallow water as a treatment in FM patients. We suggest a gradual increase in exercise duration may be warranted.https://doi.org/10.1371/journal.pone.0239473 |
| spellingShingle | Taiki Nakata Atsushi Doi Daisuke Uta Megumu Yoshimura Min-Chul Shin Excessive exercise induces cardiac arrhythmia in a young fibromyalgia mouse model. PLoS ONE |
| title | Excessive exercise induces cardiac arrhythmia in a young fibromyalgia mouse model. |
| title_full | Excessive exercise induces cardiac arrhythmia in a young fibromyalgia mouse model. |
| title_fullStr | Excessive exercise induces cardiac arrhythmia in a young fibromyalgia mouse model. |
| title_full_unstemmed | Excessive exercise induces cardiac arrhythmia in a young fibromyalgia mouse model. |
| title_short | Excessive exercise induces cardiac arrhythmia in a young fibromyalgia mouse model. |
| title_sort | excessive exercise induces cardiac arrhythmia in a young fibromyalgia mouse model |
| url | https://doi.org/10.1371/journal.pone.0239473 |
| work_keys_str_mv | AT taikinakata excessiveexerciseinducescardiacarrhythmiainayoungfibromyalgiamousemodel AT atsushidoi excessiveexerciseinducescardiacarrhythmiainayoungfibromyalgiamousemodel AT daisukeuta excessiveexerciseinducescardiacarrhythmiainayoungfibromyalgiamousemodel AT megumuyoshimura excessiveexerciseinducescardiacarrhythmiainayoungfibromyalgiamousemodel AT minchulshin excessiveexerciseinducescardiacarrhythmiainayoungfibromyalgiamousemodel |