HIV-Tat Exacerbates the Actions of Atazanavir, Efavirenz, and Ritonavir on Cardiac Ryanodine Receptor (RyR2)

HIV-Tat Exacerbates the Actions of Atazanavir, Efavirenz, and Ritonavir on Cardiac Ryanodine Receptor (RyR2)

The incidence of sudden cardiac death (SCD) in people living with HIV infection (PLWH), especially those with inadequate viral suppression, is high and the reasons for this remain incompletely characterized. The timely opening and closing of type 2 ryanodine receptor (RyR2) is critical for ensuring...

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Bibliographic Details
Main Authors: Fadhel A. Alomar, Chengju Tian, Sean R. Bidasee, Zachary L. Venn, Evan Schroder, Nicholas Y. Palermo, Mohammad AlShabeeb, Benson J. Edagwa, Jason J. Payne, Keshore R. Bidasee
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:International Journal of Molecular Sciences
Subjects:
sudden cardiac death
HIV
HIV-Tat
antiretroviral drugs
type 2 ryanodine receptor (RyR2)
[<sup>3</sup>H]ryanodine
Online Access:https://www.mdpi.com/1422-0067/24/1/274

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