Chemistry of Therapeutic Oligonucleotides That Drives Interactions with Biomolecules

Chemistry of Therapeutic Oligonucleotides That Drives Interactions with Biomolecules

Oligonucleotide therapeutics that can modulate gene expression have been gradually developed for clinical applications over several decades. However, rapid advances have been made in recent years. Artificial nucleic acid technology has overcome many challenges, such as (1) poor target affinity and s...

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Bibliographic Details
Main Authors: Chisato Terada, Seiya Kawamoto, Asako Yamayoshi, Tsuyoshi Yamamoto
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Pharmaceutics
Subjects:
oligonucleotide therapeutics
material symbiosis
oligonucleotides
phosphorothioate
antisense
siRNA
Online Access:https://www.mdpi.com/1999-4923/14/12/2647

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