The Role of Inflammatory Markers in Predicting Mortality in Critical COVID-19 Patients: A SingleCenter, Retrospective, Observational Study
Introduction: This study aims to assess the association of inflammatory markers with the clinical progression of patients diagnosed with COVID-19. Materials and Methods: Critically ill patients with COVID-19 were included. Prealbumin, lactate dehydrogenase (LDH), transferrin, procalcitonin, ferriti...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Bilimsel Tip Yayinevi
2023-03-01
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| Series: | Flora Infeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi |
| Subjects: | |
| Online Access: | http://www.floradergisi.org/managete/fu_folder/2023-01/2023-28-01-37-47.pdf |
| _version_ | 1811159285005025280 |
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| author | Elif BOMBACI Kemal Tolga SARAÇOĞLU Ayten SARAÇOĞLU Recep DEMİRHAN Fulya Çiyiltepe |
| author_facet | Elif BOMBACI Kemal Tolga SARAÇOĞLU Ayten SARAÇOĞLU Recep DEMİRHAN Fulya Çiyiltepe |
| author_sort | Elif BOMBACI |
| collection | DOAJ |
| description | Introduction: This study aims to assess the association of inflammatory markers with the clinical progression of patients diagnosed with COVID-19.
Materials and Methods: Critically ill patients with COVID-19 were included. Prealbumin, lactate dehydrogenase (LDH), transferrin, procalcitonin, ferritin, D-dimer, troponin T and C-reactive protein (CRP) were monitored. A comparison was performed between patients regarding their need for mechanical ventilation, duration of hospital and intensive care unit stay, discharge, mortality, complications,
and response to treatment in order to reveal potential correlations.
Results: A total of 107 patients were enrolled in the study. D-dimer levels on the 3rd and 6th days were significantly higher in the exitus group. Prealbumin and transferrin levels measured at baseline and on days three and six were significantly lower in the exitus group compared to the surviving group (p˂ 0.05). In the exitus group, the procalcitonin, CRP, LDH, troponin T, and ferritin levels were significantly higher on days zero, three, and six as compared to the surviving group (p˂ 0.05).
Conclusion: Our results suggest that inflammatory markers may be useful as early indicators of mortality in COVID-19 patients. |
| first_indexed | 2024-04-10T05:38:25Z |
| format | Article |
| id | doaj.art-04b2f06783134ee985ba96fba050ef02 |
| institution | Directory Open Access Journal |
| issn | 1300-932X |
| language | English |
| last_indexed | 2024-04-10T05:38:25Z |
| publishDate | 2023-03-01 |
| publisher | Bilimsel Tip Yayinevi |
| record_format | Article |
| series | Flora Infeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi |
| spelling | doaj.art-04b2f06783134ee985ba96fba050ef022023-03-06T14:15:17ZengBilimsel Tip YayineviFlora Infeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi1300-932X2023-03-01281374710.5578/flora.20239903The Role of Inflammatory Markers in Predicting Mortality in Critical COVID-19 Patients: A SingleCenter, Retrospective, Observational StudyElif BOMBACI0https://orcid.org/0000-0002-9153-140XKemal Tolga SARAÇOĞLU1https://orcid.org/0000-0001-9470-7418Ayten SARAÇOĞLU2https://orcid.org/0000-0002-1186-0933Recep DEMİRHAN3https://orcid.org/0000-0003-4424-5918Fulya Çiyiltepe4https://orcid.org/0000-0002-0959-5202Kartal Dr. Lütfi Kırdar Şehir Hastanesi, Anesteziyoloji ve Yoğun Bakım Kliniği, İstanbul, TürkiyeKartal Dr. Lütfi Kırdar Şehir Hastanesi, Anesteziyoloji ve Yoğun Bakım Kliniği, İstanbul, TürkiyeMarmara Üniversitesi Pendik Eğitim ve Araştırma Hastanesi, Anesteziyoloji ve Yoğun Bakım Kliniği, İstanbul, TürkiyeKartal Dr. Lütfi Kırdar Şehir Hastanesi, Göğüs Cerrahisi Kliniği, İstanbul, TürkiyeKartal Dr. Lütfi Kırdar Şehir Hastanesi, Anesteziyoloji ve Yoğun Bakım Kliniği, İstanbul, TürkiyeIntroduction: This study aims to assess the association of inflammatory markers with the clinical progression of patients diagnosed with COVID-19. Materials and Methods: Critically ill patients with COVID-19 were included. Prealbumin, lactate dehydrogenase (LDH), transferrin, procalcitonin, ferritin, D-dimer, troponin T and C-reactive protein (CRP) were monitored. A comparison was performed between patients regarding their need for mechanical ventilation, duration of hospital and intensive care unit stay, discharge, mortality, complications, and response to treatment in order to reveal potential correlations. Results: A total of 107 patients were enrolled in the study. D-dimer levels on the 3rd and 6th days were significantly higher in the exitus group. Prealbumin and transferrin levels measured at baseline and on days three and six were significantly lower in the exitus group compared to the surviving group (p˂ 0.05). In the exitus group, the procalcitonin, CRP, LDH, troponin T, and ferritin levels were significantly higher on days zero, three, and six as compared to the surviving group (p˂ 0.05). Conclusion: Our results suggest that inflammatory markers may be useful as early indicators of mortality in COVID-19 patients.http://www.floradergisi.org/managete/fu_folder/2023-01/2023-28-01-37-47.pdfcovid-19inflammatorymarkersmortality |
| spellingShingle | Elif BOMBACI Kemal Tolga SARAÇOĞLU Ayten SARAÇOĞLU Recep DEMİRHAN Fulya Çiyiltepe The Role of Inflammatory Markers in Predicting Mortality in Critical COVID-19 Patients: A SingleCenter, Retrospective, Observational Study Flora Infeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi covid-19 inflammatory markers mortality |
| title | The Role of Inflammatory Markers in Predicting Mortality in Critical COVID-19 Patients: A SingleCenter, Retrospective, Observational Study |
| title_full | The Role of Inflammatory Markers in Predicting Mortality in Critical COVID-19 Patients: A SingleCenter, Retrospective, Observational Study |
| title_fullStr | The Role of Inflammatory Markers in Predicting Mortality in Critical COVID-19 Patients: A SingleCenter, Retrospective, Observational Study |
| title_full_unstemmed | The Role of Inflammatory Markers in Predicting Mortality in Critical COVID-19 Patients: A SingleCenter, Retrospective, Observational Study |
| title_short | The Role of Inflammatory Markers in Predicting Mortality in Critical COVID-19 Patients: A SingleCenter, Retrospective, Observational Study |
| title_sort | role of inflammatory markers in predicting mortality in critical covid 19 patients a singlecenter retrospective observational study |
| topic | covid-19 inflammatory markers mortality |
| url | http://www.floradergisi.org/managete/fu_folder/2023-01/2023-28-01-37-47.pdf |
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