Diagnosis and treatment of hemophagocytic histiocytic sarcoma in a cat
Case summary A 7-year-old spayed female domestic shorthair cat was presented for persistent anemia of unknown origin. Splenomegaly was diagnosed through physical examination and abdominal radiographs, and an abdominal ultrasound was performed. The ultrasound showed splenomegaly, as well as one discr...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2020-10-01
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| Series: | Journal of Feline Medicine and Surgery Open Reports |
| Online Access: | https://doi.org/10.1177/2055116920957196 |
| _version_ | 1818302015329009664 |
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| author | Brian Huber Marc Leleonnec |
| author_facet | Brian Huber Marc Leleonnec |
| author_sort | Brian Huber |
| collection | DOAJ |
| description | Case summary A 7-year-old spayed female domestic shorthair cat was presented for persistent anemia of unknown origin. Splenomegaly was diagnosed through physical examination and abdominal radiographs, and an abdominal ultrasound was performed. The ultrasound showed splenomegaly, as well as one discrete mass in the body of the spleen. A splenectomy was performed and histopathology along with immunohistochemistry for CD18 and CD204 confirmed a diagnosis of hemophagocytic histiocytic sarcoma (HS). Two courses of lomustine (CCNU) chemotherapy were used in this cat along with adjuvant oral prednisolone and iron dextran injections, but the cat eventually succumbed to hepatic failure, presumed to be secondary to metastatic disease. Relevance and novel information The clinical pathology results and ultrasonographic studies performed before and after treatment in this cat provide useful preliminary information about the biologic behavior and response to treatment for this rare cancer. This is also the first reported case where both CD18 and CD204 were strongly positive, confirming hemophagocytic HS in a cat. |
| first_indexed | 2024-12-13T05:32:11Z |
| format | Article |
| id | doaj.art-04b3dd4bb3124921933e46b7f74cdb32 |
| institution | Directory Open Access Journal |
| issn | 2055-1169 |
| language | English |
| last_indexed | 2024-12-13T05:32:11Z |
| publishDate | 2020-10-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of Feline Medicine and Surgery Open Reports |
| spelling | doaj.art-04b3dd4bb3124921933e46b7f74cdb322022-12-21T23:58:01ZengSAGE PublishingJournal of Feline Medicine and Surgery Open Reports2055-11692020-10-01610.1177/2055116920957196Diagnosis and treatment of hemophagocytic histiocytic sarcoma in a catBrian Huber0Marc Leleonnec1University of Tennessee, Knoxville, TN, USASound Diagnostics, Garden City, NY, USACase summary A 7-year-old spayed female domestic shorthair cat was presented for persistent anemia of unknown origin. Splenomegaly was diagnosed through physical examination and abdominal radiographs, and an abdominal ultrasound was performed. The ultrasound showed splenomegaly, as well as one discrete mass in the body of the spleen. A splenectomy was performed and histopathology along with immunohistochemistry for CD18 and CD204 confirmed a diagnosis of hemophagocytic histiocytic sarcoma (HS). Two courses of lomustine (CCNU) chemotherapy were used in this cat along with adjuvant oral prednisolone and iron dextran injections, but the cat eventually succumbed to hepatic failure, presumed to be secondary to metastatic disease. Relevance and novel information The clinical pathology results and ultrasonographic studies performed before and after treatment in this cat provide useful preliminary information about the biologic behavior and response to treatment for this rare cancer. This is also the first reported case where both CD18 and CD204 were strongly positive, confirming hemophagocytic HS in a cat.https://doi.org/10.1177/2055116920957196 |
| spellingShingle | Brian Huber Marc Leleonnec Diagnosis and treatment of hemophagocytic histiocytic sarcoma in a cat Journal of Feline Medicine and Surgery Open Reports |
| title | Diagnosis and treatment of hemophagocytic histiocytic sarcoma in a cat |
| title_full | Diagnosis and treatment of hemophagocytic histiocytic sarcoma in a cat |
| title_fullStr | Diagnosis and treatment of hemophagocytic histiocytic sarcoma in a cat |
| title_full_unstemmed | Diagnosis and treatment of hemophagocytic histiocytic sarcoma in a cat |
| title_short | Diagnosis and treatment of hemophagocytic histiocytic sarcoma in a cat |
| title_sort | diagnosis and treatment of hemophagocytic histiocytic sarcoma in a cat |
| url | https://doi.org/10.1177/2055116920957196 |
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