Tuberculin skin test and interferon-gamma release assay values are associated with antimicrobial peptides expression in polymorphonuclear cells during latent tuberculous infection
It has been reported that patients with progressive tuberculosis (TB) express abundant amounts of the antimicrobial peptides (AMPs) cathelicidin (LL-37) and human neutrophil peptide-1 (HNP-1) in circulating cells, whereas latent TB infected donors showed no differences when compared with purified pr...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Fundação Oswaldo Cruz (FIOCRUZ)
2014-06-01
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| Series: | Memorias do Instituto Oswaldo Cruz |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762014000300330&lng=en&tlng=en |
| _version_ | 1797756610387378176 |
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| author | Julio E Castañeda-Delgado Alberto Cervantes-Villagrana Carmen J Serrano-Escobedo Isabel Frausto-Lujan Cesar Rivas-Santiago Jose A Enciso-Moreno Bruno Rivas-Santiago |
| author_facet | Julio E Castañeda-Delgado Alberto Cervantes-Villagrana Carmen J Serrano-Escobedo Isabel Frausto-Lujan Cesar Rivas-Santiago Jose A Enciso-Moreno Bruno Rivas-Santiago |
| author_sort | Julio E Castañeda-Delgado |
| collection | DOAJ |
| description | It has been reported that patients with progressive tuberculosis (TB) express abundant amounts of the antimicrobial peptides (AMPs) cathelicidin (LL-37) and human neutrophil peptide-1 (HNP-1) in circulating cells, whereas latent TB infected donors showed no differences when compared with purified protein derivative (PPD) and QuantiFERON®-TB Gold (QFT)-healthy individuals. The aim of this study was to determine whether LL-37 and HNP-1 production correlates with higher tuberculin skin test (TST) and QFT values in TB household contacts. Twenty-six TB household contact individuals between 26-58 years old TST and QFT positive with at last two years of latent TB infection were recruited. AMPs production by polymorphonuclear cells was determined by flow cytometry and correlation between TST and QFT values was analysed. Our results showed that there is a positive correlation between levels of HNP-1 and LL-37 production with reactivity to TST and/or QFT levels. This preliminary study suggests the potential use of the expression levels of these peptides as biomarkers for progression in latent infected individuals. |
| first_indexed | 2024-03-12T18:04:02Z |
| format | Article |
| id | doaj.art-04b4aafce76e4238a12a5e5f966eb5d7 |
| institution | Directory Open Access Journal |
| issn | 1678-8060 |
| language | English |
| last_indexed | 2024-03-12T18:04:02Z |
| publishDate | 2014-06-01 |
| publisher | Fundação Oswaldo Cruz (FIOCRUZ) |
| record_format | Article |
| series | Memorias do Instituto Oswaldo Cruz |
| spelling | doaj.art-04b4aafce76e4238a12a5e5f966eb5d72023-08-02T09:32:19ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz1678-80602014-06-01109333033410.1590/0074-0276140348S0074-02762014000300330Tuberculin skin test and interferon-gamma release assay values are associated with antimicrobial peptides expression in polymorphonuclear cells during latent tuberculous infectionJulio E Castañeda-DelgadoAlberto Cervantes-VillagranaCarmen J Serrano-EscobedoIsabel Frausto-LujanCesar Rivas-SantiagoJose A Enciso-MorenoBruno Rivas-SantiagoIt has been reported that patients with progressive tuberculosis (TB) express abundant amounts of the antimicrobial peptides (AMPs) cathelicidin (LL-37) and human neutrophil peptide-1 (HNP-1) in circulating cells, whereas latent TB infected donors showed no differences when compared with purified protein derivative (PPD) and QuantiFERON®-TB Gold (QFT)-healthy individuals. The aim of this study was to determine whether LL-37 and HNP-1 production correlates with higher tuberculin skin test (TST) and QFT values in TB household contacts. Twenty-six TB household contact individuals between 26-58 years old TST and QFT positive with at last two years of latent TB infection were recruited. AMPs production by polymorphonuclear cells was determined by flow cytometry and correlation between TST and QFT values was analysed. Our results showed that there is a positive correlation between levels of HNP-1 and LL-37 production with reactivity to TST and/or QFT levels. This preliminary study suggests the potential use of the expression levels of these peptides as biomarkers for progression in latent infected individuals.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762014000300330&lng=en&tlng=entuberculosislatent infectionantimicrobial peptidestuberculin skin testQuantiFERONbiomarker |
| spellingShingle | Julio E Castañeda-Delgado Alberto Cervantes-Villagrana Carmen J Serrano-Escobedo Isabel Frausto-Lujan Cesar Rivas-Santiago Jose A Enciso-Moreno Bruno Rivas-Santiago Tuberculin skin test and interferon-gamma release assay values are associated with antimicrobial peptides expression in polymorphonuclear cells during latent tuberculous infection Memorias do Instituto Oswaldo Cruz tuberculosis latent infection antimicrobial peptides tuberculin skin test QuantiFERON biomarker |
| title | Tuberculin skin test and interferon-gamma release assay values are associated with antimicrobial peptides expression in polymorphonuclear cells during latent tuberculous infection |
| title_full | Tuberculin skin test and interferon-gamma release assay values are associated with antimicrobial peptides expression in polymorphonuclear cells during latent tuberculous infection |
| title_fullStr | Tuberculin skin test and interferon-gamma release assay values are associated with antimicrobial peptides expression in polymorphonuclear cells during latent tuberculous infection |
| title_full_unstemmed | Tuberculin skin test and interferon-gamma release assay values are associated with antimicrobial peptides expression in polymorphonuclear cells during latent tuberculous infection |
| title_short | Tuberculin skin test and interferon-gamma release assay values are associated with antimicrobial peptides expression in polymorphonuclear cells during latent tuberculous infection |
| title_sort | tuberculin skin test and interferon gamma release assay values are associated with antimicrobial peptides expression in polymorphonuclear cells during latent tuberculous infection |
| topic | tuberculosis latent infection antimicrobial peptides tuberculin skin test QuantiFERON biomarker |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762014000300330&lng=en&tlng=en |
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