Recent Trends in the Antidiabetic Prominence of Natural and Synthetic Analogues of Aurones
Natural products are a boundless source for the development of pharmaceutical agents against a wide range of human diseases. Accordingly, naturally occurring aurones possess various biological benefits, such as anticancer, antioxidant, antimicrobial, antidiabetic, anti-inflammatory, antiviral and ne...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-10-01
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| Series: | Current Issues in Molecular Biology |
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| Online Access: | https://www.mdpi.com/1467-3045/45/10/533 |
| _version_ | 1797574179807035392 |
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| author | Rammohan Aluru Anindita Mukherjee Grigory V. Zyryanov Adinath Majee Sougata Santra |
| author_facet | Rammohan Aluru Anindita Mukherjee Grigory V. Zyryanov Adinath Majee Sougata Santra |
| author_sort | Rammohan Aluru |
| collection | DOAJ |
| description | Natural products are a boundless source for the development of pharmaceutical agents against a wide range of human diseases. Accordingly, naturally occurring aurones possess various biological benefits, such as anticancer, antioxidant, antimicrobial, antidiabetic, anti-inflammatory, antiviral and neuroprotective effects. In addition, various studies have revealed that aurones are potential templates for the regulation of diabetes mellitus and its associated complications. Likewise, certain aurones and their analogues have been found to be remarkable kinase inhibitors of DARK2, PPAR-γ, PTPM1, AGE, α-amylase and α-glucosidase, which represents a promising approach for the treatment of chronic metabolic disorders such as diabetes. Therefore, in our present study, we provide a detailed account of the advances in aurones as antidiabetic agents over the past decade. |
| first_indexed | 2024-03-10T21:20:15Z |
| format | Article |
| id | doaj.art-04b5a8c503534e3f852a8bef034e7ed0 |
| institution | Directory Open Access Journal |
| issn | 1467-3037 1467-3045 |
| language | English |
| last_indexed | 2024-03-10T21:20:15Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Issues in Molecular Biology |
| spelling | doaj.art-04b5a8c503534e3f852a8bef034e7ed02023-11-19T16:06:52ZengMDPI AGCurrent Issues in Molecular Biology1467-30371467-30452023-10-0145108461847510.3390/cimb45100533Recent Trends in the Antidiabetic Prominence of Natural and Synthetic Analogues of AuronesRammohan Aluru0Anindita Mukherjee1Grigory V. Zyryanov2Adinath Majee3Sougata Santra4Chemical Engineering Institute, Ural Federal University, 19 Mira Str., 620002 Yekaterinburg, RussiaChemical Engineering Institute, Ural Federal University, 19 Mira Str., 620002 Yekaterinburg, RussiaChemical Engineering Institute, Ural Federal University, 19 Mira Str., 620002 Yekaterinburg, RussiaDepartment of Chemistry, Visva-Bharati (A Central University), Birbhum, Santiniketan 731235, IndiaChemical Engineering Institute, Ural Federal University, 19 Mira Str., 620002 Yekaterinburg, RussiaNatural products are a boundless source for the development of pharmaceutical agents against a wide range of human diseases. Accordingly, naturally occurring aurones possess various biological benefits, such as anticancer, antioxidant, antimicrobial, antidiabetic, anti-inflammatory, antiviral and neuroprotective effects. In addition, various studies have revealed that aurones are potential templates for the regulation of diabetes mellitus and its associated complications. Likewise, certain aurones and their analogues have been found to be remarkable kinase inhibitors of DARK2, PPAR-γ, PTPM1, AGE, α-amylase and α-glucosidase, which represents a promising approach for the treatment of chronic metabolic disorders such as diabetes. Therefore, in our present study, we provide a detailed account of the advances in aurones as antidiabetic agents over the past decade.https://www.mdpi.com/1467-3045/45/10/533auronesantidiabeticchalconeα-glucosidase inhibitorflavonoids |
| spellingShingle | Rammohan Aluru Anindita Mukherjee Grigory V. Zyryanov Adinath Majee Sougata Santra Recent Trends in the Antidiabetic Prominence of Natural and Synthetic Analogues of Aurones Current Issues in Molecular Biology aurones antidiabetic chalcone α-glucosidase inhibitor flavonoids |
| title | Recent Trends in the Antidiabetic Prominence of Natural and Synthetic Analogues of Aurones |
| title_full | Recent Trends in the Antidiabetic Prominence of Natural and Synthetic Analogues of Aurones |
| title_fullStr | Recent Trends in the Antidiabetic Prominence of Natural and Synthetic Analogues of Aurones |
| title_full_unstemmed | Recent Trends in the Antidiabetic Prominence of Natural and Synthetic Analogues of Aurones |
| title_short | Recent Trends in the Antidiabetic Prominence of Natural and Synthetic Analogues of Aurones |
| title_sort | recent trends in the antidiabetic prominence of natural and synthetic analogues of aurones |
| topic | aurones antidiabetic chalcone α-glucosidase inhibitor flavonoids |
| url | https://www.mdpi.com/1467-3045/45/10/533 |
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