Mitochondrial Dynamics and Insulin Secretion
Mitochondria are involved in the regulation of cellular energy metabolism, calcium homeostasis, and apoptosis. For mitochondrial quality control, dynamic processes, such as mitochondrial fission and fusion, are necessary to maintain shape and function. Disturbances of mitochondrial dynamics lead to...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-09-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/24/18/13782 |
| _version_ | 1797579703345741824 |
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| author | Uma D. Kabra Martin Jastroch |
| author_facet | Uma D. Kabra Martin Jastroch |
| author_sort | Uma D. Kabra |
| collection | DOAJ |
| description | Mitochondria are involved in the regulation of cellular energy metabolism, calcium homeostasis, and apoptosis. For mitochondrial quality control, dynamic processes, such as mitochondrial fission and fusion, are necessary to maintain shape and function. Disturbances of mitochondrial dynamics lead to dysfunctional mitochondria, which contribute to the development and progression of numerous diseases, including Type 2 Diabetes (T2D). Compelling evidence has been put forward that mitochondrial dynamics play a significant role in the metabolism-secretion coupling of pancreatic β cells. The disruption of mitochondrial dynamics is linked to defects in energy production and increased apoptosis, ultimately impairing insulin secretion and β cell death. This review provides an overview of molecular mechanisms controlling mitochondrial dynamics, their dysfunction in pancreatic β cells, and pharmaceutical agents targeting mitochondrial dynamic proteins, such as mitochondrial division inhibitor-1 (mdivi-1), dynasore, P110, and 15-oxospiramilactone (S3). |
| first_indexed | 2024-03-10T22:40:51Z |
| format | Article |
| id | doaj.art-04b8bd392a564e97b98d034949a871e5 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T22:40:51Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-04b8bd392a564e97b98d034949a871e52023-11-19T11:03:01ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-09-0124181378210.3390/ijms241813782Mitochondrial Dynamics and Insulin SecretionUma D. Kabra0Martin Jastroch1Department of Pharmaceutical Chemistry, Parul Institute of Pharmacy, Parul University, Vadodara 391760, IndiaThe Arrhenius Laboratories F3, Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, SE-106 91 Stockholm, SwedenMitochondria are involved in the regulation of cellular energy metabolism, calcium homeostasis, and apoptosis. For mitochondrial quality control, dynamic processes, such as mitochondrial fission and fusion, are necessary to maintain shape and function. Disturbances of mitochondrial dynamics lead to dysfunctional mitochondria, which contribute to the development and progression of numerous diseases, including Type 2 Diabetes (T2D). Compelling evidence has been put forward that mitochondrial dynamics play a significant role in the metabolism-secretion coupling of pancreatic β cells. The disruption of mitochondrial dynamics is linked to defects in energy production and increased apoptosis, ultimately impairing insulin secretion and β cell death. This review provides an overview of molecular mechanisms controlling mitochondrial dynamics, their dysfunction in pancreatic β cells, and pharmaceutical agents targeting mitochondrial dynamic proteins, such as mitochondrial division inhibitor-1 (mdivi-1), dynasore, P110, and 15-oxospiramilactone (S3).https://www.mdpi.com/1422-0067/24/18/13782diabetesmitochondrial dynamicsglucose-stimulated insulin secretionpancreatic beta cellfusionfission |
| spellingShingle | Uma D. Kabra Martin Jastroch Mitochondrial Dynamics and Insulin Secretion International Journal of Molecular Sciences diabetes mitochondrial dynamics glucose-stimulated insulin secretion pancreatic beta cell fusion fission |
| title | Mitochondrial Dynamics and Insulin Secretion |
| title_full | Mitochondrial Dynamics and Insulin Secretion |
| title_fullStr | Mitochondrial Dynamics and Insulin Secretion |
| title_full_unstemmed | Mitochondrial Dynamics and Insulin Secretion |
| title_short | Mitochondrial Dynamics and Insulin Secretion |
| title_sort | mitochondrial dynamics and insulin secretion |
| topic | diabetes mitochondrial dynamics glucose-stimulated insulin secretion pancreatic beta cell fusion fission |
| url | https://www.mdpi.com/1422-0067/24/18/13782 |
| work_keys_str_mv | AT umadkabra mitochondrialdynamicsandinsulinsecretion AT martinjastroch mitochondrialdynamicsandinsulinsecretion |