Epstein-Barr Virus-Negative Post-Transplant Lymphoproliferative Diseases: Three Distinct Cases from a Single Center
Three cases of Epstein-Barr virus (EBV)-negative post-transplant lymphoproliferative disease that occurred 6 to 8 years after renal transplantation are reported. The patients respectively had gastric mucosa-associated lymphoid tissue lymphoma, gastric diffuse large B-cell lymphoma, and atypical Burk...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Galenos Publishing House
2014-02-01
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| Series: | Turkish Journal of Hematology |
| Subjects: | |
| Online Access: | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tjh&un=TJH-69335 |
| _version_ | 1828030133242429440 |
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| author | Şule Mine Bakanay Gülşah Kaygusuz Pervin Topçuoğlu Şule Şengül Timur Tunçalı Kenan Keven Işınsu Kuzu Akın Uysal Mutlu Arat |
| author_facet | Şule Mine Bakanay Gülşah Kaygusuz Pervin Topçuoğlu Şule Şengül Timur Tunçalı Kenan Keven Işınsu Kuzu Akın Uysal Mutlu Arat |
| author_sort | Şule Mine Bakanay |
| collection | DOAJ |
| description | Three cases of Epstein-Barr virus (EBV)-negative post-transplant lymphoproliferative disease that occurred 6 to 8 years after renal transplantation are reported. The patients respectively had gastric mucosa-associated lymphoid tissue lymphoma, gastric diffuse large B-cell lymphoma, and atypical Burkitt lymphoma. Absence of EBV in the tissue samples was demonstrated by both in situ hybridization for EBV early RNA and polymerase chain reaction for EBV DNA. Patients were treated with reduction in immunosuppression and combined chemotherapy plus an anti-CD20 monoclonal antibody, rituximab. Despite the reduction in immunosuppression, patients had stable renal functions without loss of graft functions. The patient with atypical Burkitt lymphoma had an abnormal karyotype, did not respond to treatment completely, and died due to disease progression. The other patients are still alive and in remission 5 and 3 years after diagnosis, respectively. EBV-negative post-transplant lymphoproliferative diseases are usually late-onset and are reported to have poor prognosis. Thus, reduction in immunosuppression is usually not sufficient for treatment and more aggressive approaches like rituximab with combined chemotherapy are required. |
| first_indexed | 2024-04-10T14:22:29Z |
| format | Article |
| id | doaj.art-04b8ce8475154653af57a7dd70a1a9c0 |
| institution | Directory Open Access Journal |
| issn | 1308-5263 |
| language | English |
| last_indexed | 2024-04-10T14:22:29Z |
| publishDate | 2014-02-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Turkish Journal of Hematology |
| spelling | doaj.art-04b8ce8475154653af57a7dd70a1a9c02023-02-15T16:09:16ZengGalenos Publishing HouseTurkish Journal of Hematology1308-52632014-02-01311798310.4274/Tjh.2012.0010TJH-69335Epstein-Barr Virus-Negative Post-Transplant Lymphoproliferative Diseases: Three Distinct Cases from a Single CenterŞule Mine Bakanay0Gülşah Kaygusuz1Pervin Topçuoğlu2Şule Şengül3Timur Tunçalı4Kenan Keven5Işınsu Kuzu6Akın Uysal7Mutlu Arat8Ankara University School Of Medical, Department Of Hematology, Ankara, TurkeyAnkara University School Of Medical, Department Of Pathology, Ankara, TurkeyAnkara University School Of Medical, Department Of Hematology, Ankara, TurkeyAnkara University School Of Medical, Department Of Nephrology, Ankara, TurkeyAnkara University School Of Medical, Department Of Medical Genetics, Ankara, TurkeyAnkara University School Of Medical, Department Of Nephrology, Ankara, TurkeyAnkara University School Of Medical, Department Of Pathology, Ankara, TurkeyAnkara University School Of Medical, Department Of Hematology, Ankara, TurkeyAnkara University School Of Medical, Department Of Hematology, Ankara, TurkeyThree cases of Epstein-Barr virus (EBV)-negative post-transplant lymphoproliferative disease that occurred 6 to 8 years after renal transplantation are reported. The patients respectively had gastric mucosa-associated lymphoid tissue lymphoma, gastric diffuse large B-cell lymphoma, and atypical Burkitt lymphoma. Absence of EBV in the tissue samples was demonstrated by both in situ hybridization for EBV early RNA and polymerase chain reaction for EBV DNA. Patients were treated with reduction in immunosuppression and combined chemotherapy plus an anti-CD20 monoclonal antibody, rituximab. Despite the reduction in immunosuppression, patients had stable renal functions without loss of graft functions. The patient with atypical Burkitt lymphoma had an abnormal karyotype, did not respond to treatment completely, and died due to disease progression. The other patients are still alive and in remission 5 and 3 years after diagnosis, respectively. EBV-negative post-transplant lymphoproliferative diseases are usually late-onset and are reported to have poor prognosis. Thus, reduction in immunosuppression is usually not sufficient for treatment and more aggressive approaches like rituximab with combined chemotherapy are required.https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tjh&un=TJH-69335renal transplantationpost-transplant lymphoproliferative diseaselymphomaimmunosuppressionrituximababnormal karyotype |
| spellingShingle | Şule Mine Bakanay Gülşah Kaygusuz Pervin Topçuoğlu Şule Şengül Timur Tunçalı Kenan Keven Işınsu Kuzu Akın Uysal Mutlu Arat Epstein-Barr Virus-Negative Post-Transplant Lymphoproliferative Diseases: Three Distinct Cases from a Single Center Turkish Journal of Hematology renal transplantation post-transplant lymphoproliferative disease lymphoma immunosuppression rituximab abnormal karyotype |
| title | Epstein-Barr Virus-Negative Post-Transplant Lymphoproliferative Diseases: Three Distinct Cases from a Single Center |
| title_full | Epstein-Barr Virus-Negative Post-Transplant Lymphoproliferative Diseases: Three Distinct Cases from a Single Center |
| title_fullStr | Epstein-Barr Virus-Negative Post-Transplant Lymphoproliferative Diseases: Three Distinct Cases from a Single Center |
| title_full_unstemmed | Epstein-Barr Virus-Negative Post-Transplant Lymphoproliferative Diseases: Three Distinct Cases from a Single Center |
| title_short | Epstein-Barr Virus-Negative Post-Transplant Lymphoproliferative Diseases: Three Distinct Cases from a Single Center |
| title_sort | epstein barr virus negative post transplant lymphoproliferative diseases three distinct cases from a single center |
| topic | renal transplantation post-transplant lymphoproliferative disease lymphoma immunosuppression rituximab abnormal karyotype |
| url | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tjh&un=TJH-69335 |
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