Pharmacological effects of specialized pro-resolving mediators in sepsis-induced organ dysfunction: a narrative review
Sepsis is a life-threatening syndrome of organ dysfunction, characterized by uncontrolled inflammatory response and immune dysregulation, often leading to multiple organ failure and even death. Specialized pro-resolving mediators (SPMs), which are typically thought to be formed via consecutive steps...
| 主要な著者: | , , , , , , |
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| フォーマット: | 論文 |
| 言語: | English |
| 出版事項: |
Frontiers Media S.A.
2024-09-01
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| シリーズ: | Frontiers in Immunology |
| 主題: | |
| オンライン･アクセス: | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1444740/full |
| _version_ | 1827076011182784512 |
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| author | Shujun Sun Shujun Sun Shujun Sun Shujun Sun Dong Yang Dong Yang Dong Yang Jing Lv Jing Lv Jing Lv Haifa Xia Haifa Xia Haifa Xia Zhangyan Mao Zhangyan Mao Zhangyan Mao Zhangyan Mao Xiangdong Chen Xiangdong Chen Xiangdong Chen Yafen Gao Yafen Gao Yafen Gao |
| author_facet | Shujun Sun Shujun Sun Shujun Sun Shujun Sun Dong Yang Dong Yang Dong Yang Jing Lv Jing Lv Jing Lv Haifa Xia Haifa Xia Haifa Xia Zhangyan Mao Zhangyan Mao Zhangyan Mao Zhangyan Mao Xiangdong Chen Xiangdong Chen Xiangdong Chen Yafen Gao Yafen Gao Yafen Gao |
| author_sort | Shujun Sun |
| collection | DOAJ |
| description | Sepsis is a life-threatening syndrome of organ dysfunction, characterized by uncontrolled inflammatory response and immune dysregulation, often leading to multiple organ failure and even death. Specialized pro-resolving mediators (SPMs), which are typically thought to be formed via consecutive steps of oxidation of polyenoic fatty acids, have been shown to suppress inflammation and promote timely resolution of inflammation. They are mainly divided into four categories: lipoxins, resolvins, protectins, and maresins. The SPMs may improve the prognosis of sepsis by modulating the immune and inflammatory balance, thereby holding promise for clinical applications. However, their biosynthetic and pharmacological properties are very complex. Through a literature review, we aim to comprehensively elucidate the protective mechanisms of different SPMs in sepsis and its organ damage, in order to provide sufficient theoretical basis for the future clinical translation of SPMs. |
| first_indexed | 2025-03-20T01:51:05Z |
| format | Article |
| id | doaj.art-04bb4e7d87484bc2bc6e83ef61d89368 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2025-03-20T01:51:05Z |
| publishDate | 2024-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-04bb4e7d87484bc2bc6e83ef61d893682024-10-04T12:52:33ZengFrontiers Media S.A.Frontiers in Immunology1664-32242024-09-011510.3389/fimmu.2024.14447401444740Pharmacological effects of specialized pro-resolving mediators in sepsis-induced organ dysfunction: a narrative reviewShujun Sun0Shujun Sun1Shujun Sun2Shujun Sun3Dong Yang4Dong Yang5Dong Yang6Jing Lv7Jing Lv8Jing Lv9Haifa Xia10Haifa Xia11Haifa Xia12Zhangyan Mao13Zhangyan Mao14Zhangyan Mao15Zhangyan Mao16Xiangdong Chen17Xiangdong Chen18Xiangdong Chen19Yafen Gao20Yafen Gao21Yafen Gao22Department of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaInstitute of Anesthesia and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaKey Laboratory of Anesthesiology and Resuscitation (Huazhong University of Science and Technology), Ministry of Education, Wuhan, ChinaDepartment of Pain, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaInstitute of Anesthesia and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaKey Laboratory of Anesthesiology and Resuscitation (Huazhong University of Science and Technology), Ministry of Education, Wuhan, ChinaDepartment of Pain, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaInstitute of Anesthesia and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaKey Laboratory of Anesthesiology and Resuscitation (Huazhong University of Science and Technology), Ministry of Education, Wuhan, ChinaDepartment of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaInstitute of Anesthesia and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaKey Laboratory of Anesthesiology and Resuscitation (Huazhong University of Science and Technology), Ministry of Education, Wuhan, ChinaDepartment of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaInstitute of Anesthesia and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaKey Laboratory of Anesthesiology and Resuscitation (Huazhong University of Science and Technology), Ministry of Education, Wuhan, ChinaDepartment of Pain, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaInstitute of Anesthesia and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaKey Laboratory of Anesthesiology and Resuscitation (Huazhong University of Science and Technology), Ministry of Education, Wuhan, ChinaDepartment of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaInstitute of Anesthesia and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaKey Laboratory of Anesthesiology and Resuscitation (Huazhong University of Science and Technology), Ministry of Education, Wuhan, ChinaSepsis is a life-threatening syndrome of organ dysfunction, characterized by uncontrolled inflammatory response and immune dysregulation, often leading to multiple organ failure and even death. Specialized pro-resolving mediators (SPMs), which are typically thought to be formed via consecutive steps of oxidation of polyenoic fatty acids, have been shown to suppress inflammation and promote timely resolution of inflammation. They are mainly divided into four categories: lipoxins, resolvins, protectins, and maresins. The SPMs may improve the prognosis of sepsis by modulating the immune and inflammatory balance, thereby holding promise for clinical applications. However, their biosynthetic and pharmacological properties are very complex. Through a literature review, we aim to comprehensively elucidate the protective mechanisms of different SPMs in sepsis and its organ damage, in order to provide sufficient theoretical basis for the future clinical translation of SPMs.https://www.frontiersin.org/articles/10.3389/fimmu.2024.1444740/fullspecialized pro-resolving mediators (SPMs)sepsislipoxinresolvinprotectinmaresins |
| spellingShingle | Shujun Sun Shujun Sun Shujun Sun Shujun Sun Dong Yang Dong Yang Dong Yang Jing Lv Jing Lv Jing Lv Haifa Xia Haifa Xia Haifa Xia Zhangyan Mao Zhangyan Mao Zhangyan Mao Zhangyan Mao Xiangdong Chen Xiangdong Chen Xiangdong Chen Yafen Gao Yafen Gao Yafen Gao Pharmacological effects of specialized pro-resolving mediators in sepsis-induced organ dysfunction: a narrative review Frontiers in Immunology specialized pro-resolving mediators (SPMs) sepsis lipoxin resolvin protectin maresins |
| title | Pharmacological effects of specialized pro-resolving mediators in sepsis-induced organ dysfunction: a narrative review |
| title_full | Pharmacological effects of specialized pro-resolving mediators in sepsis-induced organ dysfunction: a narrative review |
| title_fullStr | Pharmacological effects of specialized pro-resolving mediators in sepsis-induced organ dysfunction: a narrative review |
| title_full_unstemmed | Pharmacological effects of specialized pro-resolving mediators in sepsis-induced organ dysfunction: a narrative review |
| title_short | Pharmacological effects of specialized pro-resolving mediators in sepsis-induced organ dysfunction: a narrative review |
| title_sort | pharmacological effects of specialized pro resolving mediators in sepsis induced organ dysfunction a narrative review |
| topic | specialized pro-resolving mediators (SPMs) sepsis lipoxin resolvin protectin maresins |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1444740/full |
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