Cerebral and behavioral signs of impaired cognitive flexibility and stability in schizophrenia spectrum disorders
Background: Manifold cognitive deficits have been reported in schizophrenia spectrum disorders, including disturbances in flexible updating to altered circumstances as well as stabilization deficits in the face of distractors. In this functional magnetic resonance imaging study, we examined the neur...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-01-01
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| Series: | NeuroImage: Clinical |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213158221002990 |
| _version_ | 1818573765678727168 |
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| author | Isabel Standke Ima Trempler Udo Dannlowski Ricarda I. Schubotz Rebekka Lencer |
| author_facet | Isabel Standke Ima Trempler Udo Dannlowski Ricarda I. Schubotz Rebekka Lencer |
| author_sort | Isabel Standke |
| collection | DOAJ |
| description | Background: Manifold cognitive deficits have been reported in schizophrenia spectrum disorders, including disturbances in flexible updating to altered circumstances as well as stabilization deficits in the face of distractors. In this functional magnetic resonance imaging study, we examined the neural correlates of these deficits as two complementary components of predictive processing. Methods: In 22 patients with schizophrenia spectrum disorders and 22 healthy matched control participants, we applied a serial predictive switch-drift task to assess flexibility as successful detection of prediction-rule switches, and stability as successfully ignoring distractors (“drifts”). Results: Patients compared with controls less reliably detected rule switches and also less efficiently inhibited drifts. A reduced striatal response to switches or drifts correlated with weaker switch-drift-discrimination in patients, suggesting impaired gating of prediction errors. The increase in activity in anterior cingulate cortex and hippocampus for detected vs. undetected switches was reduced in patients compared to controls, which may reflect impaired behavioral adaptation following prediction errors. The comparison between shielding against distractions and undetected switches showed increased activity in the inferior frontal cortex and posterior insula in controls but not in patients. Conclusion: Our results suggest new insights into the specific disruption of predictive flexibility and stability in schizophrenia spectrum disorders, which is characterized by impaired striatal gating and inadequate cortical encoding of predictive errors. |
| first_indexed | 2024-12-15T00:17:16Z |
| format | Article |
| id | doaj.art-04bd5af23f8f402b801eed3bc2819060 |
| institution | Directory Open Access Journal |
| issn | 2213-1582 |
| language | English |
| last_indexed | 2024-12-15T00:17:16Z |
| publishDate | 2021-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage: Clinical |
| spelling | doaj.art-04bd5af23f8f402b801eed3bc28190602022-12-21T22:42:25ZengElsevierNeuroImage: Clinical2213-15822021-01-0132102855Cerebral and behavioral signs of impaired cognitive flexibility and stability in schizophrenia spectrum disordersIsabel Standke0Ima Trempler1Udo Dannlowski2Ricarda I. Schubotz3Rebekka Lencer4Institute for Translational Psychiatry, University of Muenster, Albert-Schweitzer-Campus 1 (Gebäude A9a), 48149 Muenster, GermanyOtto Creutzfeldt-Center for Cognitive and Behavioral Neuroscience, University of Muenster, Fliednerstr. 21, 48149 Muenster, Germany; Institute of Psychology, University of Muenster, Fliednerstr. 21, 48149 Muenster, GermanyInstitute for Translational Psychiatry, University of Muenster, Albert-Schweitzer-Campus 1 (Gebäude A9a), 48149 Muenster, Germany; Otto Creutzfeldt-Center for Cognitive and Behavioral Neuroscience, University of Muenster, Fliednerstr. 21, 48149 Muenster, GermanyOtto Creutzfeldt-Center for Cognitive and Behavioral Neuroscience, University of Muenster, Fliednerstr. 21, 48149 Muenster, Germany; Institute of Psychology, University of Muenster, Fliednerstr. 21, 48149 Muenster, GermanyInstitute for Translational Psychiatry, University of Muenster, Albert-Schweitzer-Campus 1 (Gebäude A9a), 48149 Muenster, Germany; Otto Creutzfeldt-Center for Cognitive and Behavioral Neuroscience, University of Muenster, Fliednerstr. 21, 48149 Muenster, Germany; Department of Psychiatry and Psychotherapy, University of Luebeck, Ratzeburger Allee 160, 23538 Luebeck, Germany; Corresponding author.Background: Manifold cognitive deficits have been reported in schizophrenia spectrum disorders, including disturbances in flexible updating to altered circumstances as well as stabilization deficits in the face of distractors. In this functional magnetic resonance imaging study, we examined the neural correlates of these deficits as two complementary components of predictive processing. Methods: In 22 patients with schizophrenia spectrum disorders and 22 healthy matched control participants, we applied a serial predictive switch-drift task to assess flexibility as successful detection of prediction-rule switches, and stability as successfully ignoring distractors (“drifts”). Results: Patients compared with controls less reliably detected rule switches and also less efficiently inhibited drifts. A reduced striatal response to switches or drifts correlated with weaker switch-drift-discrimination in patients, suggesting impaired gating of prediction errors. The increase in activity in anterior cingulate cortex and hippocampus for detected vs. undetected switches was reduced in patients compared to controls, which may reflect impaired behavioral adaptation following prediction errors. The comparison between shielding against distractions and undetected switches showed increased activity in the inferior frontal cortex and posterior insula in controls but not in patients. Conclusion: Our results suggest new insights into the specific disruption of predictive flexibility and stability in schizophrenia spectrum disorders, which is characterized by impaired striatal gating and inadequate cortical encoding of predictive errors.http://www.sciencedirect.com/science/article/pii/S2213158221002990Prediction error processingRule switchingDistractor shieldingStriatal gatingMedial prefrontal cortexLateral prefrontal cortex |
| spellingShingle | Isabel Standke Ima Trempler Udo Dannlowski Ricarda I. Schubotz Rebekka Lencer Cerebral and behavioral signs of impaired cognitive flexibility and stability in schizophrenia spectrum disorders NeuroImage: Clinical Prediction error processing Rule switching Distractor shielding Striatal gating Medial prefrontal cortex Lateral prefrontal cortex |
| title | Cerebral and behavioral signs of impaired cognitive flexibility and stability in schizophrenia spectrum disorders |
| title_full | Cerebral and behavioral signs of impaired cognitive flexibility and stability in schizophrenia spectrum disorders |
| title_fullStr | Cerebral and behavioral signs of impaired cognitive flexibility and stability in schizophrenia spectrum disorders |
| title_full_unstemmed | Cerebral and behavioral signs of impaired cognitive flexibility and stability in schizophrenia spectrum disorders |
| title_short | Cerebral and behavioral signs of impaired cognitive flexibility and stability in schizophrenia spectrum disorders |
| title_sort | cerebral and behavioral signs of impaired cognitive flexibility and stability in schizophrenia spectrum disorders |
| topic | Prediction error processing Rule switching Distractor shielding Striatal gating Medial prefrontal cortex Lateral prefrontal cortex |
| url | http://www.sciencedirect.com/science/article/pii/S2213158221002990 |
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