Influence of heart rate on right ventricular function assessed by right heart catheterization and echocardiography in healthy anesthetized dogs
Abstract Background Right ventricular (RV) functional assessment has received considerable attention in veterinary medicine since various diseases, such as cardiovascular, respiratory, endocrine, and neoplastic disease, may affect RV function. Heart rate (HR) is an important factor that can influenc...
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| Format: | Article |
| Language: | English |
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BMC
2022-05-01
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| Series: | BMC Veterinary Research |
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| Online Access: | https://doi.org/10.1186/s12917-022-03271-y |
| _version_ | 1811305804123340800 |
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| author | Yunosuke Yuchi Ryohei Suzuki Haruka Kanno Takahiro Saito Takahiro Teshima Hirotaka Matsumoto Hidekazu Koyama |
| author_facet | Yunosuke Yuchi Ryohei Suzuki Haruka Kanno Takahiro Saito Takahiro Teshima Hirotaka Matsumoto Hidekazu Koyama |
| author_sort | Yunosuke Yuchi |
| collection | DOAJ |
| description | Abstract Background Right ventricular (RV) functional assessment has received considerable attention in veterinary medicine since various diseases, such as cardiovascular, respiratory, endocrine, and neoplastic disease, may affect RV function. Heart rate (HR) is an important factor that can influence RV function through changes in loading condition and contractility. However, no study has yet evaluated the association between HR and RV function in the same individuals. This study aimed to evaluate the influence of elevated HR on RV function using right heart catheterization and echocardiography, and investigate the association between right heart catheterization and echocardiographic indices. Results Right atrial pacing was performed in eight dogs at 120, 140, 160, and 180 bpm. With an increase in HR, the RV systolic volume, RV diastolic volume, and stroke volume significantly decreased; however, the cardiac output, end-systolic elastance (Ees), and effective arterial elastance (Ea) significantly increased. Significant changes were not observed in RV pressure and Ees/Ea. The RV area normalized by body weight, RV fractional area change normalized by body weight (RV FACn), and tricuspid annular plane systolic excursion normalized by body weight (TAPSEn) significantly decreased with increased HR. Peak systolic myocardial velocity of the lateral tricuspid annulus (RV s’), RV strain, and RV strain rate of only the RV free wall analysis (RV-SrL3seg) showed no significant changes with the increase in HR; however, there was an increase in the RV strain rate of the RV global analysis (RV-SrL6seg). Multiple regression analysis revealed that HR, RV FACn, and RV- SrL6seg had significant associations with the Ees, and the TAPSEn and RV-SrL3seg with Ees/Ea. Conclusions Decreased venous return and shortened relaxation time decreased the RV FAC, TAPSE, RV s’, and RV strain, and might underestimate the RV function. Ees increased with the increase in HR, reflecting the myocardial force-frequency relation; as a result, RV-SrL6seg could be a useful tool for Ees estimation. Additionally, the RV-SrL3seg could detect RV performance, reflecting the balance between RV contractility and RV afterload. |
| first_indexed | 2024-04-13T08:32:59Z |
| format | Article |
| id | doaj.art-04bdf2a76efb4d81baa8ecafe373f849 |
| institution | Directory Open Access Journal |
| issn | 1746-6148 |
| language | English |
| last_indexed | 2024-04-13T08:32:59Z |
| publishDate | 2022-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Veterinary Research |
| spelling | doaj.art-04bdf2a76efb4d81baa8ecafe373f8492022-12-22T02:54:11ZengBMCBMC Veterinary Research1746-61482022-05-0118111210.1186/s12917-022-03271-yInfluence of heart rate on right ventricular function assessed by right heart catheterization and echocardiography in healthy anesthetized dogsYunosuke Yuchi0Ryohei Suzuki1Haruka Kanno2Takahiro Saito3Takahiro Teshima4Hirotaka Matsumoto5Hidekazu Koyama6Laboratory of Veterinary Internal Medicine, School of Veterinary Medicine, Faculty of Veterinary Science, Nippon Veterinary and Life Science UniversityLaboratory of Veterinary Internal Medicine, School of Veterinary Medicine, Faculty of Veterinary Science, Nippon Veterinary and Life Science UniversityLaboratory of Veterinary Internal Medicine, School of Veterinary Medicine, Faculty of Veterinary Science, Nippon Veterinary and Life Science UniversityLaboratory of Veterinary Internal Medicine, School of Veterinary Medicine, Faculty of Veterinary Science, Nippon Veterinary and Life Science UniversityLaboratory of Veterinary Internal Medicine, School of Veterinary Medicine, Faculty of Veterinary Science, Nippon Veterinary and Life Science UniversityLaboratory of Veterinary Internal Medicine, School of Veterinary Medicine, Faculty of Veterinary Science, Nippon Veterinary and Life Science UniversityLaboratory of Veterinary Internal Medicine, School of Veterinary Medicine, Faculty of Veterinary Science, Nippon Veterinary and Life Science UniversityAbstract Background Right ventricular (RV) functional assessment has received considerable attention in veterinary medicine since various diseases, such as cardiovascular, respiratory, endocrine, and neoplastic disease, may affect RV function. Heart rate (HR) is an important factor that can influence RV function through changes in loading condition and contractility. However, no study has yet evaluated the association between HR and RV function in the same individuals. This study aimed to evaluate the influence of elevated HR on RV function using right heart catheterization and echocardiography, and investigate the association between right heart catheterization and echocardiographic indices. Results Right atrial pacing was performed in eight dogs at 120, 140, 160, and 180 bpm. With an increase in HR, the RV systolic volume, RV diastolic volume, and stroke volume significantly decreased; however, the cardiac output, end-systolic elastance (Ees), and effective arterial elastance (Ea) significantly increased. Significant changes were not observed in RV pressure and Ees/Ea. The RV area normalized by body weight, RV fractional area change normalized by body weight (RV FACn), and tricuspid annular plane systolic excursion normalized by body weight (TAPSEn) significantly decreased with increased HR. Peak systolic myocardial velocity of the lateral tricuspid annulus (RV s’), RV strain, and RV strain rate of only the RV free wall analysis (RV-SrL3seg) showed no significant changes with the increase in HR; however, there was an increase in the RV strain rate of the RV global analysis (RV-SrL6seg). Multiple regression analysis revealed that HR, RV FACn, and RV- SrL6seg had significant associations with the Ees, and the TAPSEn and RV-SrL3seg with Ees/Ea. Conclusions Decreased venous return and shortened relaxation time decreased the RV FAC, TAPSE, RV s’, and RV strain, and might underestimate the RV function. Ees increased with the increase in HR, reflecting the myocardial force-frequency relation; as a result, RV-SrL6seg could be a useful tool for Ees estimation. Additionally, the RV-SrL3seg could detect RV performance, reflecting the balance between RV contractility and RV afterload.https://doi.org/10.1186/s12917-022-03271-yBowditch effectElastanceForce-frequency relationPressure–volume loopRight ventricular contractilityRight ventricular performance |
| spellingShingle | Yunosuke Yuchi Ryohei Suzuki Haruka Kanno Takahiro Saito Takahiro Teshima Hirotaka Matsumoto Hidekazu Koyama Influence of heart rate on right ventricular function assessed by right heart catheterization and echocardiography in healthy anesthetized dogs BMC Veterinary Research Bowditch effect Elastance Force-frequency relation Pressure–volume loop Right ventricular contractility Right ventricular performance |
| title | Influence of heart rate on right ventricular function assessed by right heart catheterization and echocardiography in healthy anesthetized dogs |
| title_full | Influence of heart rate on right ventricular function assessed by right heart catheterization and echocardiography in healthy anesthetized dogs |
| title_fullStr | Influence of heart rate on right ventricular function assessed by right heart catheterization and echocardiography in healthy anesthetized dogs |
| title_full_unstemmed | Influence of heart rate on right ventricular function assessed by right heart catheterization and echocardiography in healthy anesthetized dogs |
| title_short | Influence of heart rate on right ventricular function assessed by right heart catheterization and echocardiography in healthy anesthetized dogs |
| title_sort | influence of heart rate on right ventricular function assessed by right heart catheterization and echocardiography in healthy anesthetized dogs |
| topic | Bowditch effect Elastance Force-frequency relation Pressure–volume loop Right ventricular contractility Right ventricular performance |
| url | https://doi.org/10.1186/s12917-022-03271-y |
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