Mitochondrial Defunctionalization Supresses Tim-3-Galectin-9 Secretory Pathway in Human Colorectal Cancer Cells and Thus Can Possibly Affect Tumor Immune Escape
The Tim-3-galectin-9 secretory pathway is known to protect various types of cancer cells against host immune surveillance. We found that pharmacologically induced mitochondrial dysfunction leads to a reduced galectin-9 expression/exocytosis in human colorectal cancer cells and re-distribution of thi...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-04-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fphar.2019.00342/full |
| _version_ | 1819106602581491712 |
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| author | Svetlana S. Sakhnevych Inna M. Yasinska Elizaveta Fasler-Kan Elizaveta Fasler-Kan Vadim V. Sumbayev |
| author_facet | Svetlana S. Sakhnevych Inna M. Yasinska Elizaveta Fasler-Kan Elizaveta Fasler-Kan Vadim V. Sumbayev |
| author_sort | Svetlana S. Sakhnevych |
| collection | DOAJ |
| description | The Tim-3-galectin-9 secretory pathway is known to protect various types of cancer cells against host immune surveillance. We found that pharmacologically induced mitochondrial dysfunction leads to a reduced galectin-9 expression/exocytosis in human colorectal cancer cells and re-distribution of this protein (the effect described for various cellular proteins) into mitochondria. |
| first_indexed | 2024-12-22T02:40:45Z |
| format | Article |
| id | doaj.art-04bf3f042a8c4aa5aeb752fb467d9380 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-22T02:40:45Z |
| publishDate | 2019-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-04bf3f042a8c4aa5aeb752fb467d93802022-12-21T18:41:38ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122019-04-011010.3389/fphar.2019.00342443172Mitochondrial Defunctionalization Supresses Tim-3-Galectin-9 Secretory Pathway in Human Colorectal Cancer Cells and Thus Can Possibly Affect Tumor Immune EscapeSvetlana S. Sakhnevych0Inna M. Yasinska1Elizaveta Fasler-Kan2Elizaveta Fasler-Kan3Vadim V. Sumbayev4Medway School of Pharmacy, Universities of Kent and Greenwich, Chatham, United KingdomMedway School of Pharmacy, Universities of Kent and Greenwich, Chatham, United KingdomDepartment of Pediatric Surgery and Department of Biomedical Research, Children's Hospital, Inselspital, University of Bern, Bern, SwitzerlandDepartment of Biomedicine, University Hospital Basel and University of Basel, Basel, SwitzerlandMedway School of Pharmacy, Universities of Kent and Greenwich, Chatham, United KingdomThe Tim-3-galectin-9 secretory pathway is known to protect various types of cancer cells against host immune surveillance. We found that pharmacologically induced mitochondrial dysfunction leads to a reduced galectin-9 expression/exocytosis in human colorectal cancer cells and re-distribution of this protein (the effect described for various cellular proteins) into mitochondria.https://www.frontiersin.org/article/10.3389/fphar.2019.00342/fullgalectin-9Tim-3immune surveillancemitochondriacolorectal cancer |
| spellingShingle | Svetlana S. Sakhnevych Inna M. Yasinska Elizaveta Fasler-Kan Elizaveta Fasler-Kan Vadim V. Sumbayev Mitochondrial Defunctionalization Supresses Tim-3-Galectin-9 Secretory Pathway in Human Colorectal Cancer Cells and Thus Can Possibly Affect Tumor Immune Escape Frontiers in Pharmacology galectin-9 Tim-3 immune surveillance mitochondria colorectal cancer |
| title | Mitochondrial Defunctionalization Supresses Tim-3-Galectin-9 Secretory Pathway in Human Colorectal Cancer Cells and Thus Can Possibly Affect Tumor Immune Escape |
| title_full | Mitochondrial Defunctionalization Supresses Tim-3-Galectin-9 Secretory Pathway in Human Colorectal Cancer Cells and Thus Can Possibly Affect Tumor Immune Escape |
| title_fullStr | Mitochondrial Defunctionalization Supresses Tim-3-Galectin-9 Secretory Pathway in Human Colorectal Cancer Cells and Thus Can Possibly Affect Tumor Immune Escape |
| title_full_unstemmed | Mitochondrial Defunctionalization Supresses Tim-3-Galectin-9 Secretory Pathway in Human Colorectal Cancer Cells and Thus Can Possibly Affect Tumor Immune Escape |
| title_short | Mitochondrial Defunctionalization Supresses Tim-3-Galectin-9 Secretory Pathway in Human Colorectal Cancer Cells and Thus Can Possibly Affect Tumor Immune Escape |
| title_sort | mitochondrial defunctionalization supresses tim 3 galectin 9 secretory pathway in human colorectal cancer cells and thus can possibly affect tumor immune escape |
| topic | galectin-9 Tim-3 immune surveillance mitochondria colorectal cancer |
| url | https://www.frontiersin.org/article/10.3389/fphar.2019.00342/full |
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