Characterization of postoperative LASIK ectasia features on higher-order aberration excimer ablation maps
Abstract Background To characterize anterior corneal higher-order aberration (HOA) excimer ablation map patterns in postoperative LASIK ectasia (POE) and to examine correlations between newly identified corneal HOA ablation map features of POE and known topographic indices. Methods Prospective multi...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-12-01
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| Series: | BMC Ophthalmology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12886-023-03263-y |
| _version_ | 1797377089378189312 |
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| author | Avi Wallerstein Sangeetha Santhakumaran Lauren Tabunar Mark Cohen Mathieu Gauvin |
| author_facet | Avi Wallerstein Sangeetha Santhakumaran Lauren Tabunar Mark Cohen Mathieu Gauvin |
| author_sort | Avi Wallerstein |
| collection | DOAJ |
| description | Abstract Background To characterize anterior corneal higher-order aberration (HOA) excimer ablation map patterns in postoperative LASIK ectasia (POE) and to examine correlations between newly identified corneal HOA ablation map features of POE and known topographic indices. Methods Prospective multicenter non-interventional descriptive study. A total of 28 eyes from 22 POE patients were enrolled. The postoperative HOA ablation map was derived from Topolyzer Vario corneal imaging at the time of POE diagnosis. Features that recurred were identified and then analyzed. Correlations to Orbscan indices were studied. Results An arrangement of two elliptical paracentral ablation islands, deep inferior and shallow superior, in direct mirror-like opposition to each other, were identified on all HOA maps. The paracentral islands were accompanied by peripheral ablation crescents. The deep paracentral inferior island ‘hot spot’ coincided with the topographical apical POE cone and was highly reproducible in angular position (249.3 ± 17.3°). There was significant variation in ablation depth (shallow superior island: 11.5 ± 6.9 μm and deep inferior island: 32.5 ± 18.8 μm). The superior crescents had high variability in depth (34.8 ± 18.9 μm). Strong correlations were found between the corneal irregularity index and the ablation depth difference between the deep and shallow paracentral islands (R = 0.96; P < 0.0001). Conclusion The corneal HOA excimer ablation map revealed a recurring, distinct, easily recognizable pattern in POE eyes. Validated Orbscan POE indices and HOA ablation map islands showed a strong correlation. It is possible to extract useful information from the corneal HOA ablation map, potentially making it suitable for diagnosing and monitoring POE although more studies are needed. |
| first_indexed | 2024-03-08T19:47:58Z |
| format | Article |
| id | doaj.art-04bf72afab45472f90efe206a680fffb |
| institution | Directory Open Access Journal |
| issn | 1471-2415 |
| language | English |
| last_indexed | 2024-03-08T19:47:58Z |
| publishDate | 2023-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Ophthalmology |
| spelling | doaj.art-04bf72afab45472f90efe206a680fffb2023-12-24T12:12:28ZengBMCBMC Ophthalmology1471-24152023-12-0123111110.1186/s12886-023-03263-yCharacterization of postoperative LASIK ectasia features on higher-order aberration excimer ablation mapsAvi Wallerstein0Sangeetha Santhakumaran1Lauren Tabunar2Mark Cohen3Mathieu Gauvin4LASIK MDDepartment of Ophthalmology, Queen’s UniversityDepartment of Ophthalmology and Visual Sciences, McGill UniversityDepartment of Ophthalmology and Visual Sciences, McGill UniversityLASIK MDAbstract Background To characterize anterior corneal higher-order aberration (HOA) excimer ablation map patterns in postoperative LASIK ectasia (POE) and to examine correlations between newly identified corneal HOA ablation map features of POE and known topographic indices. Methods Prospective multicenter non-interventional descriptive study. A total of 28 eyes from 22 POE patients were enrolled. The postoperative HOA ablation map was derived from Topolyzer Vario corneal imaging at the time of POE diagnosis. Features that recurred were identified and then analyzed. Correlations to Orbscan indices were studied. Results An arrangement of two elliptical paracentral ablation islands, deep inferior and shallow superior, in direct mirror-like opposition to each other, were identified on all HOA maps. The paracentral islands were accompanied by peripheral ablation crescents. The deep paracentral inferior island ‘hot spot’ coincided with the topographical apical POE cone and was highly reproducible in angular position (249.3 ± 17.3°). There was significant variation in ablation depth (shallow superior island: 11.5 ± 6.9 μm and deep inferior island: 32.5 ± 18.8 μm). The superior crescents had high variability in depth (34.8 ± 18.9 μm). Strong correlations were found between the corneal irregularity index and the ablation depth difference between the deep and shallow paracentral islands (R = 0.96; P < 0.0001). Conclusion The corneal HOA excimer ablation map revealed a recurring, distinct, easily recognizable pattern in POE eyes. Validated Orbscan POE indices and HOA ablation map islands showed a strong correlation. It is possible to extract useful information from the corneal HOA ablation map, potentially making it suitable for diagnosing and monitoring POE although more studies are needed.https://doi.org/10.1186/s12886-023-03263-yTopographyContouraEctasiaDiagnosisHigher-order aberration |
| spellingShingle | Avi Wallerstein Sangeetha Santhakumaran Lauren Tabunar Mark Cohen Mathieu Gauvin Characterization of postoperative LASIK ectasia features on higher-order aberration excimer ablation maps BMC Ophthalmology Topography Contoura Ectasia Diagnosis Higher-order aberration |
| title | Characterization of postoperative LASIK ectasia features on higher-order aberration excimer ablation maps |
| title_full | Characterization of postoperative LASIK ectasia features on higher-order aberration excimer ablation maps |
| title_fullStr | Characterization of postoperative LASIK ectasia features on higher-order aberration excimer ablation maps |
| title_full_unstemmed | Characterization of postoperative LASIK ectasia features on higher-order aberration excimer ablation maps |
| title_short | Characterization of postoperative LASIK ectasia features on higher-order aberration excimer ablation maps |
| title_sort | characterization of postoperative lasik ectasia features on higher order aberration excimer ablation maps |
| topic | Topography Contoura Ectasia Diagnosis Higher-order aberration |
| url | https://doi.org/10.1186/s12886-023-03263-y |
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