Population genomics of Group B Streptococcus reveals the genetics of neonatal disease onset and meningeal invasion

Group B Streptococcus (GBS) causes neonatal disease and mortality worldwide. Here, the authors use genome-wide association analyses to identify bacterial genetic signatures associated with disease onset time and meningeal tissue infection in acute invasive neonatal GBS disease.

Bibliographic Details
Main Authors: Chrispin Chaguza, Dorota Jamrozy, Merijn W. Bijlsma, Taco W. Kuijpers, Diederik van de Beek, Arie van der Ende, Stephen D. Bentley
Format: Article
Language:English
Published: Nature Portfolio 2022-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-31858-4
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author Chrispin Chaguza
Dorota Jamrozy
Merijn W. Bijlsma
Taco W. Kuijpers
Diederik van de Beek
Arie van der Ende
Stephen D. Bentley
author_facet Chrispin Chaguza
Dorota Jamrozy
Merijn W. Bijlsma
Taco W. Kuijpers
Diederik van de Beek
Arie van der Ende
Stephen D. Bentley
author_sort Chrispin Chaguza
collection DOAJ
description Group B Streptococcus (GBS) causes neonatal disease and mortality worldwide. Here, the authors use genome-wide association analyses to identify bacterial genetic signatures associated with disease onset time and meningeal tissue infection in acute invasive neonatal GBS disease.
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spelling doaj.art-04c2bc39e9eb46dfa6ef5d7e2c6856b82022-12-22T02:31:50ZengNature PortfolioNature Communications2041-17232022-07-0113111310.1038/s41467-022-31858-4Population genomics of Group B Streptococcus reveals the genetics of neonatal disease onset and meningeal invasionChrispin Chaguza0Dorota Jamrozy1Merijn W. Bijlsma2Taco W. Kuijpers3Diederik van de Beek4Arie van der Ende5Stephen D. Bentley6Parasites and Microbes Programme, Wellcome Sanger Institute, Wellcome Genome CampusParasites and Microbes Programme, Wellcome Sanger Institute, Wellcome Genome CampusDepartment of Neurology, Amsterdam Neuroscience, Amsterdam University Medical Center, University of AmsterdamDepartment of Immunopathology, Sanquin Research and Landsteiner Laboratory of the Academic Medical Center, University of AmsterdamDepartment of Neurology, Amsterdam Neuroscience, Amsterdam University Medical Center, University of AmsterdamDepartment of Medical Microbiology, Amsterdam Infection and Immunity, Amsterdam University Medical Center, University of AmsterdamParasites and Microbes Programme, Wellcome Sanger Institute, Wellcome Genome CampusGroup B Streptococcus (GBS) causes neonatal disease and mortality worldwide. Here, the authors use genome-wide association analyses to identify bacterial genetic signatures associated with disease onset time and meningeal tissue infection in acute invasive neonatal GBS disease.https://doi.org/10.1038/s41467-022-31858-4
spellingShingle Chrispin Chaguza
Dorota Jamrozy
Merijn W. Bijlsma
Taco W. Kuijpers
Diederik van de Beek
Arie van der Ende
Stephen D. Bentley
Population genomics of Group B Streptococcus reveals the genetics of neonatal disease onset and meningeal invasion
Nature Communications
title Population genomics of Group B Streptococcus reveals the genetics of neonatal disease onset and meningeal invasion
title_full Population genomics of Group B Streptococcus reveals the genetics of neonatal disease onset and meningeal invasion
title_fullStr Population genomics of Group B Streptococcus reveals the genetics of neonatal disease onset and meningeal invasion
title_full_unstemmed Population genomics of Group B Streptococcus reveals the genetics of neonatal disease onset and meningeal invasion
title_short Population genomics of Group B Streptococcus reveals the genetics of neonatal disease onset and meningeal invasion
title_sort population genomics of group b streptococcus reveals the genetics of neonatal disease onset and meningeal invasion
url https://doi.org/10.1038/s41467-022-31858-4
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