Population genomics of Group B Streptococcus reveals the genetics of neonatal disease onset and meningeal invasion
Group B Streptococcus (GBS) causes neonatal disease and mortality worldwide. Here, the authors use genome-wide association analyses to identify bacterial genetic signatures associated with disease onset time and meningeal tissue infection in acute invasive neonatal GBS disease.
Main Authors: | , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2022-07-01
|
Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-022-31858-4 |
_version_ | 1828328576343080960 |
---|---|
author | Chrispin Chaguza Dorota Jamrozy Merijn W. Bijlsma Taco W. Kuijpers Diederik van de Beek Arie van der Ende Stephen D. Bentley |
author_facet | Chrispin Chaguza Dorota Jamrozy Merijn W. Bijlsma Taco W. Kuijpers Diederik van de Beek Arie van der Ende Stephen D. Bentley |
author_sort | Chrispin Chaguza |
collection | DOAJ |
description | Group B Streptococcus (GBS) causes neonatal disease and mortality worldwide. Here, the authors use genome-wide association analyses to identify bacterial genetic signatures associated with disease onset time and meningeal tissue infection in acute invasive neonatal GBS disease. |
first_indexed | 2024-04-13T20:11:24Z |
format | Article |
id | doaj.art-04c2bc39e9eb46dfa6ef5d7e2c6856b8 |
institution | Directory Open Access Journal |
issn | 2041-1723 |
language | English |
last_indexed | 2024-04-13T20:11:24Z |
publishDate | 2022-07-01 |
publisher | Nature Portfolio |
record_format | Article |
series | Nature Communications |
spelling | doaj.art-04c2bc39e9eb46dfa6ef5d7e2c6856b82022-12-22T02:31:50ZengNature PortfolioNature Communications2041-17232022-07-0113111310.1038/s41467-022-31858-4Population genomics of Group B Streptococcus reveals the genetics of neonatal disease onset and meningeal invasionChrispin Chaguza0Dorota Jamrozy1Merijn W. Bijlsma2Taco W. Kuijpers3Diederik van de Beek4Arie van der Ende5Stephen D. Bentley6Parasites and Microbes Programme, Wellcome Sanger Institute, Wellcome Genome CampusParasites and Microbes Programme, Wellcome Sanger Institute, Wellcome Genome CampusDepartment of Neurology, Amsterdam Neuroscience, Amsterdam University Medical Center, University of AmsterdamDepartment of Immunopathology, Sanquin Research and Landsteiner Laboratory of the Academic Medical Center, University of AmsterdamDepartment of Neurology, Amsterdam Neuroscience, Amsterdam University Medical Center, University of AmsterdamDepartment of Medical Microbiology, Amsterdam Infection and Immunity, Amsterdam University Medical Center, University of AmsterdamParasites and Microbes Programme, Wellcome Sanger Institute, Wellcome Genome CampusGroup B Streptococcus (GBS) causes neonatal disease and mortality worldwide. Here, the authors use genome-wide association analyses to identify bacterial genetic signatures associated with disease onset time and meningeal tissue infection in acute invasive neonatal GBS disease.https://doi.org/10.1038/s41467-022-31858-4 |
spellingShingle | Chrispin Chaguza Dorota Jamrozy Merijn W. Bijlsma Taco W. Kuijpers Diederik van de Beek Arie van der Ende Stephen D. Bentley Population genomics of Group B Streptococcus reveals the genetics of neonatal disease onset and meningeal invasion Nature Communications |
title | Population genomics of Group B Streptococcus reveals the genetics of neonatal disease onset and meningeal invasion |
title_full | Population genomics of Group B Streptococcus reveals the genetics of neonatal disease onset and meningeal invasion |
title_fullStr | Population genomics of Group B Streptococcus reveals the genetics of neonatal disease onset and meningeal invasion |
title_full_unstemmed | Population genomics of Group B Streptococcus reveals the genetics of neonatal disease onset and meningeal invasion |
title_short | Population genomics of Group B Streptococcus reveals the genetics of neonatal disease onset and meningeal invasion |
title_sort | population genomics of group b streptococcus reveals the genetics of neonatal disease onset and meningeal invasion |
url | https://doi.org/10.1038/s41467-022-31858-4 |
work_keys_str_mv | AT chrispinchaguza populationgenomicsofgroupbstreptococcusrevealsthegeneticsofneonataldiseaseonsetandmeningealinvasion AT dorotajamrozy populationgenomicsofgroupbstreptococcusrevealsthegeneticsofneonataldiseaseonsetandmeningealinvasion AT merijnwbijlsma populationgenomicsofgroupbstreptococcusrevealsthegeneticsofneonataldiseaseonsetandmeningealinvasion AT tacowkuijpers populationgenomicsofgroupbstreptococcusrevealsthegeneticsofneonataldiseaseonsetandmeningealinvasion AT diederikvandebeek populationgenomicsofgroupbstreptococcusrevealsthegeneticsofneonataldiseaseonsetandmeningealinvasion AT arievanderende populationgenomicsofgroupbstreptococcusrevealsthegeneticsofneonataldiseaseonsetandmeningealinvasion AT stephendbentley populationgenomicsofgroupbstreptococcusrevealsthegeneticsofneonataldiseaseonsetandmeningealinvasion |