Biomarkers of Central Nervous System Involvement from Epithelial Ovarian Cancer
Epithelial ovarian cancer (EOC) is the leading cause of death among women affected by gynaecological malignancies. Most patients show advanced disease at diagnosis (FIGO stage III-IV) and, despite the introduction of new therapeutic options, most women experience relapses. In most cases, recurrence...
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MDPI AG
2021-12-01
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| author | Giulia Scotto Fulvio Borella Margherita Turinetto Valentina Tuninetti Anna A. Valsecchi Gaia Giannone Stefano Cosma Chiara Benedetto Giorgio Valabrega |
| author_facet | Giulia Scotto Fulvio Borella Margherita Turinetto Valentina Tuninetti Anna A. Valsecchi Gaia Giannone Stefano Cosma Chiara Benedetto Giorgio Valabrega |
| author_sort | Giulia Scotto |
| collection | DOAJ |
| description | Epithelial ovarian cancer (EOC) is the leading cause of death among women affected by gynaecological malignancies. Most patients show advanced disease at diagnosis (FIGO stage III-IV) and, despite the introduction of new therapeutic options, most women experience relapses. In most cases, recurrence is abdominal-pelvic; however, EOC can occasionally metastasize to distant organs, including the central nervous system. The incidence of brain metastases (BMs) from EOC is low, but it has grown over time; currently, there are no follow-up strategies available. In the last decade, a few biomarkers able to predict the risk of developing BMs from OC or as potential therapeutic targets have been investigated by several authors; to date, none have entered clinical practice. The purpose of this review is to offer a summary on the role of the most relevant predictors of central nervous system (CNS) involvement (hormone receptors; BRCA; MRD1; PD-1/PD-L1) and to highlight possible therapeutic strategies for the management of metastatic brain disease in EOC |
| first_indexed | 2024-03-10T04:25:25Z |
| format | Article |
| id | doaj.art-04c36cfa31eb4488a102ff18696d6e77 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T04:25:25Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-04c36cfa31eb4488a102ff18696d6e772023-11-23T07:37:22ZengMDPI AGCells2073-44092021-12-011012340810.3390/cells10123408Biomarkers of Central Nervous System Involvement from Epithelial Ovarian CancerGiulia Scotto0Fulvio Borella1Margherita Turinetto2Valentina Tuninetti3Anna A. Valsecchi4Gaia Giannone5Stefano Cosma6Chiara Benedetto7Giorgio Valabrega8Department of Oncology, University of Torino, 10123 Torino, ItalyGynecology and Obstetrics 1, Department of Surgical Sciences, City of Health and Science, University of Turin, 10126 Turin, ItalyDepartment of Oncology, University of Torino, 10123 Torino, ItalyDepartment of Oncology, University of Torino, 10123 Torino, ItalyDepartment of Oncology, University of Torino, 10123 Torino, ItalyDepartment of Oncology, University of Torino, 10123 Torino, ItalyGynecology and Obstetrics 1, Department of Surgical Sciences, City of Health and Science, University of Turin, 10126 Turin, ItalyGynecology and Obstetrics 1, Department of Surgical Sciences, City of Health and Science, University of Turin, 10126 Turin, ItalyDepartment of Oncology, University of Torino, 10123 Torino, ItalyEpithelial ovarian cancer (EOC) is the leading cause of death among women affected by gynaecological malignancies. Most patients show advanced disease at diagnosis (FIGO stage III-IV) and, despite the introduction of new therapeutic options, most women experience relapses. In most cases, recurrence is abdominal-pelvic; however, EOC can occasionally metastasize to distant organs, including the central nervous system. The incidence of brain metastases (BMs) from EOC is low, but it has grown over time; currently, there are no follow-up strategies available. In the last decade, a few biomarkers able to predict the risk of developing BMs from OC or as potential therapeutic targets have been investigated by several authors; to date, none have entered clinical practice. The purpose of this review is to offer a summary on the role of the most relevant predictors of central nervous system (CNS) involvement (hormone receptors; BRCA; MRD1; PD-1/PD-L1) and to highlight possible therapeutic strategies for the management of metastatic brain disease in EOChttps://www.mdpi.com/2073-4409/10/12/3408brain metastasesovarian cancerbiomarker |
| spellingShingle | Giulia Scotto Fulvio Borella Margherita Turinetto Valentina Tuninetti Anna A. Valsecchi Gaia Giannone Stefano Cosma Chiara Benedetto Giorgio Valabrega Biomarkers of Central Nervous System Involvement from Epithelial Ovarian Cancer Cells brain metastases ovarian cancer biomarker |
| title | Biomarkers of Central Nervous System Involvement from Epithelial Ovarian Cancer |
| title_full | Biomarkers of Central Nervous System Involvement from Epithelial Ovarian Cancer |
| title_fullStr | Biomarkers of Central Nervous System Involvement from Epithelial Ovarian Cancer |
| title_full_unstemmed | Biomarkers of Central Nervous System Involvement from Epithelial Ovarian Cancer |
| title_short | Biomarkers of Central Nervous System Involvement from Epithelial Ovarian Cancer |
| title_sort | biomarkers of central nervous system involvement from epithelial ovarian cancer |
| topic | brain metastases ovarian cancer biomarker |
| url | https://www.mdpi.com/2073-4409/10/12/3408 |
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