Molecularly Imprinted Polymer-Based Sensors for the Detection of Skeletal- and Cardiac-Muscle-Related Analytes
Molecularly imprinted polymers (MIPs) are synthetic polymers with specific binding sites that present high affinity and spatial and chemical complementarities to a targeted analyte. They mimic the molecular recognition seen naturally in the antibody/antigen complementarity. Because of their specific...
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| Format: | Article |
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MDPI AG
2023-06-01
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| Series: | Sensors |
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| Online Access: | https://www.mdpi.com/1424-8220/23/12/5625 |
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| author | Serge Ostrovidov Murugan Ramalingam Hojae Bae Gorka Orive Toshinori Fujie Takeshi Hori Yuji Nashimoto Xuetao Shi Hirokazu Kaji |
| author_facet | Serge Ostrovidov Murugan Ramalingam Hojae Bae Gorka Orive Toshinori Fujie Takeshi Hori Yuji Nashimoto Xuetao Shi Hirokazu Kaji |
| author_sort | Serge Ostrovidov |
| collection | DOAJ |
| description | Molecularly imprinted polymers (MIPs) are synthetic polymers with specific binding sites that present high affinity and spatial and chemical complementarities to a targeted analyte. They mimic the molecular recognition seen naturally in the antibody/antigen complementarity. Because of their specificity, MIPs can be included in sensors as a recognition element coupled to a transducer part that converts the interaction of MIP/analyte into a quantifiable signal. Such sensors have important applications in the biomedical field in diagnosis and drug discovery, and are a necessary complement of tissue engineering for analyzing the functionalities of the engineered tissues. Therefore, in this review, we provide an overview of MIP sensors that have been used for the detection of skeletal- and cardiac-muscle-related analytes. We organized this review by targeted analytes in alphabetical order. Thus, after an introduction to the fabrication of MIPs, we highlight different types of MIP sensors with an emphasis on recent works and show their great diversity, their fabrication, their linear range for a given analyte, their limit of detection (LOD), specificity, and reproducibility. We conclude the review with future developments and perspectives. |
| first_indexed | 2024-03-11T01:56:36Z |
| format | Article |
| id | doaj.art-04c3c66193ea40ccbbfc2e2a66cba504 |
| institution | Directory Open Access Journal |
| issn | 1424-8220 |
| language | English |
| last_indexed | 2024-03-11T01:56:36Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Sensors |
| spelling | doaj.art-04c3c66193ea40ccbbfc2e2a66cba5042023-11-18T12:33:45ZengMDPI AGSensors1424-82202023-06-012312562510.3390/s23125625Molecularly Imprinted Polymer-Based Sensors for the Detection of Skeletal- and Cardiac-Muscle-Related AnalytesSerge Ostrovidov0Murugan Ramalingam1Hojae Bae2Gorka Orive3Toshinori Fujie4Takeshi Hori5Yuji Nashimoto6Xuetao Shi7Hirokazu Kaji8Department of Diagnostic and Therapeutic Systems Engineering, Institute of Biomaterials and Bioengineering (IBB), Tokyo Medical and Dental University (TMDU), Tokyo 101-0062, JapanInstitute of Tissue Regeneration Engineering, Dankook University, Cheonan 31116, Republic of KoreaKU Convergence Science and Technology Institute, Department of Stem Cell and Regenerative Biotechnology, Konkuk University, Hwayang-dong, Kwangjin-gu, Seoul 05029, Republic of KoreaNanoBioCel Group, Laboratory of Pharmaceutics, School of Pharmacy, University of the Basque Country UPV/EHU, 01006 Vitoria-Gasteiz, SpainSchool of Life Science and Technology, Tokyo Institute of Technology, Yokohama 226-8501, JapanDepartment of Diagnostic and Therapeutic Systems Engineering, Institute of Biomaterials and Bioengineering (IBB), Tokyo Medical and Dental University (TMDU), Tokyo 101-0062, JapanDepartment of Diagnostic and Therapeutic Systems Engineering, Institute of Biomaterials and Bioengineering (IBB), Tokyo Medical and Dental University (TMDU), Tokyo 101-0062, JapanNational Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou 510006, ChinaDepartment of Diagnostic and Therapeutic Systems Engineering, Institute of Biomaterials and Bioengineering (IBB), Tokyo Medical and Dental University (TMDU), Tokyo 101-0062, JapanMolecularly imprinted polymers (MIPs) are synthetic polymers with specific binding sites that present high affinity and spatial and chemical complementarities to a targeted analyte. They mimic the molecular recognition seen naturally in the antibody/antigen complementarity. Because of their specificity, MIPs can be included in sensors as a recognition element coupled to a transducer part that converts the interaction of MIP/analyte into a quantifiable signal. Such sensors have important applications in the biomedical field in diagnosis and drug discovery, and are a necessary complement of tissue engineering for analyzing the functionalities of the engineered tissues. Therefore, in this review, we provide an overview of MIP sensors that have been used for the detection of skeletal- and cardiac-muscle-related analytes. We organized this review by targeted analytes in alphabetical order. Thus, after an introduction to the fabrication of MIPs, we highlight different types of MIP sensors with an emphasis on recent works and show their great diversity, their fabrication, their linear range for a given analyte, their limit of detection (LOD), specificity, and reproducibility. We conclude the review with future developments and perspectives.https://www.mdpi.com/1424-8220/23/12/5625molecularly imprinted polymers (MIP)biomaterialssensorsskeletal musclecardiac muscle |
| spellingShingle | Serge Ostrovidov Murugan Ramalingam Hojae Bae Gorka Orive Toshinori Fujie Takeshi Hori Yuji Nashimoto Xuetao Shi Hirokazu Kaji Molecularly Imprinted Polymer-Based Sensors for the Detection of Skeletal- and Cardiac-Muscle-Related Analytes Sensors molecularly imprinted polymers (MIP) biomaterials sensors skeletal muscle cardiac muscle |
| title | Molecularly Imprinted Polymer-Based Sensors for the Detection of Skeletal- and Cardiac-Muscle-Related Analytes |
| title_full | Molecularly Imprinted Polymer-Based Sensors for the Detection of Skeletal- and Cardiac-Muscle-Related Analytes |
| title_fullStr | Molecularly Imprinted Polymer-Based Sensors for the Detection of Skeletal- and Cardiac-Muscle-Related Analytes |
| title_full_unstemmed | Molecularly Imprinted Polymer-Based Sensors for the Detection of Skeletal- and Cardiac-Muscle-Related Analytes |
| title_short | Molecularly Imprinted Polymer-Based Sensors for the Detection of Skeletal- and Cardiac-Muscle-Related Analytes |
| title_sort | molecularly imprinted polymer based sensors for the detection of skeletal and cardiac muscle related analytes |
| topic | molecularly imprinted polymers (MIP) biomaterials sensors skeletal muscle cardiac muscle |
| url | https://www.mdpi.com/1424-8220/23/12/5625 |
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