Association between systemic lupus erythematosus and inflammatory bowel disease in European and East Asian populations: a two-sample Mendelian randomization study
BackgroundPrevious studies have shown a coexistence phenomenon between systemic lupus erythematosus (SLE) and inflammatory bowel disease (IBD), but the causal relationship between them is still unclear. Therefore, we conducted a two-sample Mendelian randomization (MR) analysis using publicly availab...
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Frontiers Media S.A.
2023-11-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1199896/full |
| _version_ | 1797639896700026880 |
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| author | Weidong Xie Haojie Jiang Yao Chen Huanhao Zhang Yaoyu Song Zhaojie Yu Huayan Gu Hongkai Xu Saiyi Han Sen Li Naxin Liu Shaoliang Han |
| author_facet | Weidong Xie Haojie Jiang Yao Chen Huanhao Zhang Yaoyu Song Zhaojie Yu Huayan Gu Hongkai Xu Saiyi Han Sen Li Naxin Liu Shaoliang Han |
| author_sort | Weidong Xie |
| collection | DOAJ |
| description | BackgroundPrevious studies have shown a coexistence phenomenon between systemic lupus erythematosus (SLE) and inflammatory bowel disease (IBD), but the causal relationship between them is still unclear. Therefore, we conducted a two-sample Mendelian randomization (MR) analysis using publicly available summary statistics data to evaluate whether there was a causal relationship between the two diseases.MethodsSummary statistics for SLE and IBD were downloaded from the Open Genome-Wide Association Study and the International Inflammatory Bowel Disease Genetics Consortium. European and East Asian populations were included in this MR work. We adopted a series of methods to select instrumental variables that are closely related to SLE and IBD. To make the conclusion more reliable, we applied a variety of different analysis methods, among which the inverse variance–weighted (IVW) method was the main method. In addition, heterogeneity, pleiotropy, and sensitivity were assessed to make the conclusions more convincing.ResultsIn the European population, a negative causal relationship was observed between SLE and overall IBD (OR = 0.94; 95% CI = 0.90, 0.98; P < 0.004) and ulcerative colitis (UC) (OR = 0.93; 95% CI = 0.88, 0.98; P = 0.006). After removing outliers with Mendelian Randomization Pleiotropy RESidual Sum and Outlier (MR-PRESSO), the results remained consistent with IVW. However, there was no causal relationship between SLE and Crohn’s disease. In the East Asian population, no causal relationship was found between SLE and IBD.ConclusionOur results found that genetic susceptibility to SLE was associated with lower overall IBD risk and UC risk in European populations. In contrast, no association between SLE and IBD was found in East Asian populations. This work might enrich the previous research results, and it may provide some references for research in the future. |
| first_indexed | 2024-03-11T13:24:07Z |
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| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-03-11T13:24:07Z |
| publishDate | 2023-11-01 |
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| series | Frontiers in Immunology |
| spelling | doaj.art-04c5dc769de94ec4a39778964db950e62023-11-03T09:36:45ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-11-011410.3389/fimmu.2023.11998961199896Association between systemic lupus erythematosus and inflammatory bowel disease in European and East Asian populations: a two-sample Mendelian randomization studyWeidong Xie0Haojie Jiang1Yao Chen2Huanhao Zhang3Yaoyu Song4Zhaojie Yu5Huayan Gu6Hongkai Xu7Saiyi Han8Sen Li9Naxin Liu10Shaoliang Han11Department of The Gastrointestinal Surgery, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, ChinaDepartment of The Gastrointestinal Surgery, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, ChinaDepartment of Medical Oncology, Sir Run Run Shaw Hospital, School of Medicine, Graduate School, Zhejiang University, Hangzhou, ChinaWenzhou Medical University, Wenzhou, ChinaWenzhou Medical University, Wenzhou, ChinaWenzhou Medical University, Wenzhou, ChinaDepartment of Breast Surgery, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, ChinaDepartment of The Gastrointestinal Surgery, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, ChinaThe Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou people’s Hospital, Quzhou, ChinaSchool of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, ChinaDepartment of The Gastrointestinal Surgery, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, ChinaDepartment of The Gastrointestinal Surgery, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, ChinaBackgroundPrevious studies have shown a coexistence phenomenon between systemic lupus erythematosus (SLE) and inflammatory bowel disease (IBD), but the causal relationship between them is still unclear. Therefore, we conducted a two-sample Mendelian randomization (MR) analysis using publicly available summary statistics data to evaluate whether there was a causal relationship between the two diseases.MethodsSummary statistics for SLE and IBD were downloaded from the Open Genome-Wide Association Study and the International Inflammatory Bowel Disease Genetics Consortium. European and East Asian populations were included in this MR work. We adopted a series of methods to select instrumental variables that are closely related to SLE and IBD. To make the conclusion more reliable, we applied a variety of different analysis methods, among which the inverse variance–weighted (IVW) method was the main method. In addition, heterogeneity, pleiotropy, and sensitivity were assessed to make the conclusions more convincing.ResultsIn the European population, a negative causal relationship was observed between SLE and overall IBD (OR = 0.94; 95% CI = 0.90, 0.98; P < 0.004) and ulcerative colitis (UC) (OR = 0.93; 95% CI = 0.88, 0.98; P = 0.006). After removing outliers with Mendelian Randomization Pleiotropy RESidual Sum and Outlier (MR-PRESSO), the results remained consistent with IVW. However, there was no causal relationship between SLE and Crohn’s disease. In the East Asian population, no causal relationship was found between SLE and IBD.ConclusionOur results found that genetic susceptibility to SLE was associated with lower overall IBD risk and UC risk in European populations. In contrast, no association between SLE and IBD was found in East Asian populations. This work might enrich the previous research results, and it may provide some references for research in the future.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1199896/fullMendelian randomization (MR)systemic lupus erythematosus (SLE)inflammatory bowel disease (IBD)ulcerative colitis (UC)Crohn’s-disease (CD) |
| spellingShingle | Weidong Xie Haojie Jiang Yao Chen Huanhao Zhang Yaoyu Song Zhaojie Yu Huayan Gu Hongkai Xu Saiyi Han Sen Li Naxin Liu Shaoliang Han Association between systemic lupus erythematosus and inflammatory bowel disease in European and East Asian populations: a two-sample Mendelian randomization study Frontiers in Immunology Mendelian randomization (MR) systemic lupus erythematosus (SLE) inflammatory bowel disease (IBD) ulcerative colitis (UC) Crohn’s-disease (CD) |
| title | Association between systemic lupus erythematosus and inflammatory bowel disease in European and East Asian populations: a two-sample Mendelian randomization study |
| title_full | Association between systemic lupus erythematosus and inflammatory bowel disease in European and East Asian populations: a two-sample Mendelian randomization study |
| title_fullStr | Association between systemic lupus erythematosus and inflammatory bowel disease in European and East Asian populations: a two-sample Mendelian randomization study |
| title_full_unstemmed | Association between systemic lupus erythematosus and inflammatory bowel disease in European and East Asian populations: a two-sample Mendelian randomization study |
| title_short | Association between systemic lupus erythematosus and inflammatory bowel disease in European and East Asian populations: a two-sample Mendelian randomization study |
| title_sort | association between systemic lupus erythematosus and inflammatory bowel disease in european and east asian populations a two sample mendelian randomization study |
| topic | Mendelian randomization (MR) systemic lupus erythematosus (SLE) inflammatory bowel disease (IBD) ulcerative colitis (UC) Crohn’s-disease (CD) |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1199896/full |
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