Effect of antiepileptic drugs on P300 event-related potentials in patients with epilepsy
Epilepsy is one of the most prevalent chronic neurological diseases, affecting about 70 million people worldwide. Patients with epilepsy often encounter cognitive dysfunction, which is influenced by different factors including age at the onset of epilepsy, etiology of epilepsy, type of seizures,...
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| Format: | Article |
| Language: | English |
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Sestre Milosrdnice University hospital, Institute of Clinical Medical Research
2021-01-01
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| Series: | Acta Clinica Croatica |
| Subjects: | |
| Online Access: | https://hrcak.srce.hr/file/412780 |
| _version_ | 1797206630504333312 |
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| author | Jelena Šarić Jurić Stjepan Jurić Ivana Marković Petra Jurić Ivana Jurić |
| author_facet | Jelena Šarić Jurić Stjepan Jurić Ivana Marković Petra Jurić Ivana Jurić |
| author_sort | Jelena Šarić Jurić |
| collection | DOAJ |
| description | Epilepsy is one of the most prevalent chronic neurological diseases, affecting about
70 million people worldwide. Patients with epilepsy often encounter cognitive dysfunction, which is
influenced by different factors including age at the onset of epilepsy, etiology of epilepsy, type of seizures,
seizure frequency and duration, psychiatric comorbidity, and antiepileptic drug (AED) therapy.
Event-related potentials are useful, noninvasive, objective clinical and research instrument for evaluation
of cognitive functions in patients. The aim of this study was to investigate and determine the effect
of AED monotherapy and polytherapy on cognitive changes in patients with epilepsy, detected
with P300 event-related potentials and compared with age- and gender-matched healthy individuals.
The study was conducted in 82 patients with generalized and focal epilepsy and 82 healthy individuals
aged 18-65 years. Cognitive evoked P300 potentials were recorded in all study subjects using auditory
‘oddball’ paradigm. The results showed the patients taking AED polytherapy to have a significantly
longer P300 latency and significantly lower N200-P300 amplitude. These results indicate that AED
polytherapy might worsen cognitive impairment in patients with epilepsy. |
| first_indexed | 2024-04-24T09:10:04Z |
| format | Article |
| id | doaj.art-04c7a679885e49c99f72dcbfb44418a5 |
| institution | Directory Open Access Journal |
| issn | 0353-9466 1333-9451 |
| language | English |
| last_indexed | 2024-04-24T09:10:04Z |
| publishDate | 2021-01-01 |
| publisher | Sestre Milosrdnice University hospital, Institute of Clinical Medical Research |
| record_format | Article |
| series | Acta Clinica Croatica |
| spelling | doaj.art-04c7a679885e49c99f72dcbfb44418a52024-04-15T18:02:17ZengSestre Milosrdnice University hospital, Institute of Clinical Medical ResearchActa Clinica Croatica0353-94661333-94512021-01-0160.Supplement 3394310.20471/acc.2021.60.s3.05Effect of antiepileptic drugs on P300 event-related potentials in patients with epilepsyJelena Šarić Jurić0Stjepan Jurić1Ivana Marković2Petra Jurić3Ivana Jurić4Department of Neurology, Osijek University Hospital Centre, Osijek, Croatia; Department of Neurology and Neurosurgery, Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia; Department of Psychiatry and Neurology, Faculty of Dental Medicine and Health, Josip Juraj Strossmayer University, Osijek, CroatiaDepartment of Neurology, Osijek University Hospital Centre, Osijek, Croatia; Department of Neurology and Neurosurgery, Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia; Department of Psychiatry and Neurology, Faculty of Dental Medicine and Health, Josip Juraj Strossmayer University, Osijek, CroatiaDepartment of Psychiatry and Neurology, Faculty of Dental Medicine and Health, Josip Juraj Strossmayer University, Osijek, Croatia; Department of Neurology, Dubrava University Hospital, Zagreb, CroatiaDepartment of Neurology and Neurosurgery, Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, CroatiaDepartment of Neurology and Neurosurgery, Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, CroatiaEpilepsy is one of the most prevalent chronic neurological diseases, affecting about 70 million people worldwide. Patients with epilepsy often encounter cognitive dysfunction, which is influenced by different factors including age at the onset of epilepsy, etiology of epilepsy, type of seizures, seizure frequency and duration, psychiatric comorbidity, and antiepileptic drug (AED) therapy. Event-related potentials are useful, noninvasive, objective clinical and research instrument for evaluation of cognitive functions in patients. The aim of this study was to investigate and determine the effect of AED monotherapy and polytherapy on cognitive changes in patients with epilepsy, detected with P300 event-related potentials and compared with age- and gender-matched healthy individuals. The study was conducted in 82 patients with generalized and focal epilepsy and 82 healthy individuals aged 18-65 years. Cognitive evoked P300 potentials were recorded in all study subjects using auditory ‘oddball’ paradigm. The results showed the patients taking AED polytherapy to have a significantly longer P300 latency and significantly lower N200-P300 amplitude. These results indicate that AED polytherapy might worsen cognitive impairment in patients with epilepsy.https://hrcak.srce.hr/file/412780Antiepileptic drugsEpilepsyP300 event-related potentialsCognitive impairment |
| spellingShingle | Jelena Šarić Jurić Stjepan Jurić Ivana Marković Petra Jurić Ivana Jurić Effect of antiepileptic drugs on P300 event-related potentials in patients with epilepsy Acta Clinica Croatica Antiepileptic drugs Epilepsy P300 event-related potentials Cognitive impairment |
| title | Effect of antiepileptic drugs on P300 event-related potentials in patients with epilepsy |
| title_full | Effect of antiepileptic drugs on P300 event-related potentials in patients with epilepsy |
| title_fullStr | Effect of antiepileptic drugs on P300 event-related potentials in patients with epilepsy |
| title_full_unstemmed | Effect of antiepileptic drugs on P300 event-related potentials in patients with epilepsy |
| title_short | Effect of antiepileptic drugs on P300 event-related potentials in patients with epilepsy |
| title_sort | effect of antiepileptic drugs on p300 event related potentials in patients with epilepsy |
| topic | Antiepileptic drugs Epilepsy P300 event-related potentials Cognitive impairment |
| url | https://hrcak.srce.hr/file/412780 |
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