Prognostic Significance of Uric Acid Levels in Intracerebral Hemorrhage Patients
Wenpei Wu,1,2,* Zhi Geng,3– 5,* Aimei Wu,2,* Xinyi Chen,6,7 Xiaoying Meng,2 Qianyun Zhang,2 Zheng Tan,2 Hong Yue,2 Juncang Wu1,2 1Department of Neurology, Hefei Second People’s Hospital Affiliated to Bengbu Medical University, Hefei, Anhui, 230011, People’s Republic of China;...
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| Format: | Article |
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Dove Medical Press
2024-03-01
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| Series: | Neuropsychiatric Disease and Treatment |
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| Online Access: | https://www.dovepress.com/prognostic-significance-of-uric-acid-levels-in-intracerebral-hemorrhag-peer-reviewed-fulltext-article-NDT |
| _version_ | 1797279364766760960 |
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| author | Wu W Geng Z Wu A Chen X Meng X Zhang Q Tan Z Yue H Wu J |
| author_facet | Wu W Geng Z Wu A Chen X Meng X Zhang Q Tan Z Yue H Wu J |
| author_sort | Wu W |
| collection | DOAJ |
| description | Wenpei Wu,1,2,* Zhi Geng,3– 5,* Aimei Wu,2,* Xinyi Chen,6,7 Xiaoying Meng,2 Qianyun Zhang,2 Zheng Tan,2 Hong Yue,2 Juncang Wu1,2 1Department of Neurology, Hefei Second People’s Hospital Affiliated to Bengbu Medical University, Hefei, Anhui, 230011, People’s Republic of China; 2Department of Neurology, Hefei Second People’s Hospital, Hefei, Anhui, 230011, People’s Republic of China; 3Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, People’s Republic of China; 4Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, Hefei, People’s Republic of China; 5Collaborative Innovation Centre of Neuropsychiatric Disorder and Mental Health, Hefei, 230000, People’s Republic of China; 6Department of Neurology, Hefei Hospital Affiliated to Anhui Medical University (Hefei Second People’s Hospital), Hefei, Anhui, 230011, People’s Republic of China; 7The Fifth Clinical School of Medicine, Anhui Medical University, Hefei, Anhui, 230011, People’s Republic of China*These authors contributed equally to this workCorrespondence: Juncang Wu; Hong Yue, Intersection of Guangde Road and Leshui Road, Hefei, Anhui, 230011, People’s Republic of China, Tel/Fax +86 551 13956076148 ; +86 551 18949855780, Email wujuncang126@126.com; yuehong01@foxmail.comBackground and Purpose: The role of serum uric acid (UA) level in patients suffering from stroke remains controversial. Our aim was to investigate the effect of UA level on clinical outcomes in patients with intracerebral hemorrhage (ICH).Methods: In the retrospective cohort study, we analyzed data from 250 patients with intracerebral hemorrhage (85 women and 165 men) to investigate the difference in UA levels between patients with a good prognosis and those with a poor prognosis. Additionally, we analyzed the impact of UA levels on the risk of short-time prognosis of ICH patients.Results: Patients with a good prognosis presented with significantly lower levels of UA (348.71 ± 84.97 μmol/L) than those with poor prognosis (393.06 ± 148.46 μmol/L). Furthermore, multivariate logistic regression model demonstrated that a high UA level was a likely risk factor for worse prognosis among patients suffering in ICH (odds ratio [95% confidence interval], 1.006 [1.0012, 1.0108]; P = 0.015). Additionally, UA has a threshold effect value of 363.9 μmol/L and was presented in levels that were in a nonlinear relationship with incidence rate of short-time prognosis outcome of ICH patients.Conclusion: Our findings indicate that higher UA levels can increase the risk of poor clinical prognosis in patients with ICH and high UA levels are not conductive to the clinical prognosis of patients with ICH. These findings provide a new perspective on the treatment and prevention of ICH.Keywords: intracerebral hemorrhage, uric acid, oxidative stress, follow-up, nonlinear relationship, prognosis |
| first_indexed | 2024-03-07T16:24:13Z |
| format | Article |
| id | doaj.art-04c7f979fa7e4a748cb2c3cf3320a23a |
| institution | Directory Open Access Journal |
| issn | 1178-2021 |
| language | English |
| last_indexed | 2024-03-07T16:24:13Z |
| publishDate | 2024-03-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Neuropsychiatric Disease and Treatment |
| spelling | doaj.art-04c7f979fa7e4a748cb2c3cf3320a23a2024-03-03T18:36:48ZengDove Medical PressNeuropsychiatric Disease and Treatment1178-20212024-03-01Volume 2044945890855Prognostic Significance of Uric Acid Levels in Intracerebral Hemorrhage PatientsWu WGeng ZWu AChen XMeng XZhang QTan ZYue HWu JWenpei Wu,1,2,* Zhi Geng,3– 5,* Aimei Wu,2,* Xinyi Chen,6,7 Xiaoying Meng,2 Qianyun Zhang,2 Zheng Tan,2 Hong Yue,2 Juncang Wu1,2 1Department of Neurology, Hefei Second People’s Hospital Affiliated to Bengbu Medical University, Hefei, Anhui, 230011, People’s Republic of China; 2Department of Neurology, Hefei Second People’s Hospital, Hefei, Anhui, 230011, People’s Republic of China; 3Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, People’s Republic of China; 4Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, Hefei, People’s Republic of China; 5Collaborative Innovation Centre of Neuropsychiatric Disorder and Mental Health, Hefei, 230000, People’s Republic of China; 6Department of Neurology, Hefei Hospital Affiliated to Anhui Medical University (Hefei Second People’s Hospital), Hefei, Anhui, 230011, People’s Republic of China; 7The Fifth Clinical School of Medicine, Anhui Medical University, Hefei, Anhui, 230011, People’s Republic of China*These authors contributed equally to this workCorrespondence: Juncang Wu; Hong Yue, Intersection of Guangde Road and Leshui Road, Hefei, Anhui, 230011, People’s Republic of China, Tel/Fax +86 551 13956076148 ; +86 551 18949855780, Email wujuncang126@126.com; yuehong01@foxmail.comBackground and Purpose: The role of serum uric acid (UA) level in patients suffering from stroke remains controversial. Our aim was to investigate the effect of UA level on clinical outcomes in patients with intracerebral hemorrhage (ICH).Methods: In the retrospective cohort study, we analyzed data from 250 patients with intracerebral hemorrhage (85 women and 165 men) to investigate the difference in UA levels between patients with a good prognosis and those with a poor prognosis. Additionally, we analyzed the impact of UA levels on the risk of short-time prognosis of ICH patients.Results: Patients with a good prognosis presented with significantly lower levels of UA (348.71 ± 84.97 μmol/L) than those with poor prognosis (393.06 ± 148.46 μmol/L). Furthermore, multivariate logistic regression model demonstrated that a high UA level was a likely risk factor for worse prognosis among patients suffering in ICH (odds ratio [95% confidence interval], 1.006 [1.0012, 1.0108]; P = 0.015). Additionally, UA has a threshold effect value of 363.9 μmol/L and was presented in levels that were in a nonlinear relationship with incidence rate of short-time prognosis outcome of ICH patients.Conclusion: Our findings indicate that higher UA levels can increase the risk of poor clinical prognosis in patients with ICH and high UA levels are not conductive to the clinical prognosis of patients with ICH. These findings provide a new perspective on the treatment and prevention of ICH.Keywords: intracerebral hemorrhage, uric acid, oxidative stress, follow-up, nonlinear relationship, prognosishttps://www.dovepress.com/prognostic-significance-of-uric-acid-levels-in-intracerebral-hemorrhag-peer-reviewed-fulltext-article-NDTintracerebral hemorrhageuric acidoxidative stressfollow-upnonlinear relationshipprognosis |
| spellingShingle | Wu W Geng Z Wu A Chen X Meng X Zhang Q Tan Z Yue H Wu J Prognostic Significance of Uric Acid Levels in Intracerebral Hemorrhage Patients Neuropsychiatric Disease and Treatment intracerebral hemorrhage uric acid oxidative stress follow-up nonlinear relationship prognosis |
| title | Prognostic Significance of Uric Acid Levels in Intracerebral Hemorrhage Patients |
| title_full | Prognostic Significance of Uric Acid Levels in Intracerebral Hemorrhage Patients |
| title_fullStr | Prognostic Significance of Uric Acid Levels in Intracerebral Hemorrhage Patients |
| title_full_unstemmed | Prognostic Significance of Uric Acid Levels in Intracerebral Hemorrhage Patients |
| title_short | Prognostic Significance of Uric Acid Levels in Intracerebral Hemorrhage Patients |
| title_sort | prognostic significance of uric acid levels in intracerebral hemorrhage patients |
| topic | intracerebral hemorrhage uric acid oxidative stress follow-up nonlinear relationship prognosis |
| url | https://www.dovepress.com/prognostic-significance-of-uric-acid-levels-in-intracerebral-hemorrhag-peer-reviewed-fulltext-article-NDT |
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