Mig‐6 could inhibit cell proliferation and induce apoptosis in esophageal squamous cell carcinoma
Abstract Background To investigate the expression and biological functions of mitogen‐induced gene 6 (Mig‐6) in esophageal squamous cell carcinoma (ESCC). Methods The expression of Mig‐6 in ESCC tissues and normal esophageal epithelial tissues were measured by immunohistochemistry (IHC) assay. MTT t...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-01-01
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| Series: | Thoracic Cancer |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/1759-7714.14223 |
| _version_ | 1828346052942495744 |
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| author | Yuantao Cui Ying Kang Peng Zhang Yuanguo Wang Zhaoyu Yang Chao Lu Peng Zhang |
| author_facet | Yuantao Cui Ying Kang Peng Zhang Yuanguo Wang Zhaoyu Yang Chao Lu Peng Zhang |
| author_sort | Yuantao Cui |
| collection | DOAJ |
| description | Abstract Background To investigate the expression and biological functions of mitogen‐induced gene 6 (Mig‐6) in esophageal squamous cell carcinoma (ESCC). Methods The expression of Mig‐6 in ESCC tissues and normal esophageal epithelial tissues were measured by immunohistochemistry (IHC) assay. MTT test was applied to detect the proliferative ability of ESCC cells after Mig‐6 was upregulated by transfection. A fluid cytology assay was used to detect apoptosis of ESCC cells. Agilent whole human genome oligo microarray was used to screen different expressed genes and the possible signaling pathways which might be involved. Results The expression of Mig‐6 protein was lower in ESCC tissues compared to normal esophageal epithelial tissues. Mig‐6 could restrain the ESCC cell growth and induce cell apoptosis. PPAR, CAMs and MAPK signaling pathways might be involved. Conclusions Mig‐6 might be a new tumor suppressor gene and a possible target for the specific therapy of ESCC. |
| first_indexed | 2024-04-14T00:20:32Z |
| format | Article |
| id | doaj.art-04c8870ed2a14350b8af15e0879aa84b |
| institution | Directory Open Access Journal |
| issn | 1759-7706 1759-7714 |
| language | English |
| last_indexed | 2024-04-14T00:20:32Z |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Thoracic Cancer |
| spelling | doaj.art-04c8870ed2a14350b8af15e0879aa84b2022-12-22T02:22:58ZengWileyThoracic Cancer1759-77061759-77142022-01-01131546010.1111/1759-7714.14223Mig‐6 could inhibit cell proliferation and induce apoptosis in esophageal squamous cell carcinomaYuantao Cui0Ying Kang1Peng Zhang2Yuanguo Wang3Zhaoyu Yang4Chao Lu5Peng Zhang6Department of Cardiothoracic Surgery Tianjin Medical University General Hospital, Tianjin Medical University Tianjin ChinaDepartment of Cardiothoracic Surgery Tianjin Medical University General Hospital, Tianjin Medical University Tianjin ChinaDepartment of Cardiothoracic Surgery Tianjin Medical University General Hospital, Tianjin Medical University Tianjin ChinaDepartment of Cardiothoracic Surgery Tianjin Medical University General Hospital, Tianjin Medical University Tianjin ChinaDepartment of Cardiothoracic Surgery Tianjin Medical University General Hospital, Tianjin Medical University Tianjin ChinaDepartment of Cardiothoracic Surgery Tianjin Medical University General Hospital, Tianjin Medical University Tianjin ChinaDepartment of Cardiothoracic Surgery Tianjin Medical University General Hospital, Tianjin Medical University Tianjin ChinaAbstract Background To investigate the expression and biological functions of mitogen‐induced gene 6 (Mig‐6) in esophageal squamous cell carcinoma (ESCC). Methods The expression of Mig‐6 in ESCC tissues and normal esophageal epithelial tissues were measured by immunohistochemistry (IHC) assay. MTT test was applied to detect the proliferative ability of ESCC cells after Mig‐6 was upregulated by transfection. A fluid cytology assay was used to detect apoptosis of ESCC cells. Agilent whole human genome oligo microarray was used to screen different expressed genes and the possible signaling pathways which might be involved. Results The expression of Mig‐6 protein was lower in ESCC tissues compared to normal esophageal epithelial tissues. Mig‐6 could restrain the ESCC cell growth and induce cell apoptosis. PPAR, CAMs and MAPK signaling pathways might be involved. Conclusions Mig‐6 might be a new tumor suppressor gene and a possible target for the specific therapy of ESCC.https://doi.org/10.1111/1759-7714.14223apoptosisESCCMig‐6pathwayproliferation |
| spellingShingle | Yuantao Cui Ying Kang Peng Zhang Yuanguo Wang Zhaoyu Yang Chao Lu Peng Zhang Mig‐6 could inhibit cell proliferation and induce apoptosis in esophageal squamous cell carcinoma Thoracic Cancer apoptosis ESCC Mig‐6 pathway proliferation |
| title | Mig‐6 could inhibit cell proliferation and induce apoptosis in esophageal squamous cell carcinoma |
| title_full | Mig‐6 could inhibit cell proliferation and induce apoptosis in esophageal squamous cell carcinoma |
| title_fullStr | Mig‐6 could inhibit cell proliferation and induce apoptosis in esophageal squamous cell carcinoma |
| title_full_unstemmed | Mig‐6 could inhibit cell proliferation and induce apoptosis in esophageal squamous cell carcinoma |
| title_short | Mig‐6 could inhibit cell proliferation and induce apoptosis in esophageal squamous cell carcinoma |
| title_sort | mig 6 could inhibit cell proliferation and induce apoptosis in esophageal squamous cell carcinoma |
| topic | apoptosis ESCC Mig‐6 pathway proliferation |
| url | https://doi.org/10.1111/1759-7714.14223 |
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