Prediction of primary breast cancer size and T-stage using micro-computed tomography in lumpectomy specimens
Background: Histopathology is the only accepted method to measure and stage the breast tumor size. However, there is a need to find another method to measure and stage the tumor size when the pathological assessment is not available. Micro-computed tomography. (micro-CT) has the ability to measure t...
| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2015-01-01
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| Series: | Journal of Pathology Informatics |
| Subjects: | |
| Online Access: | http://www.jpathinformatics.org/article.asp?issn=2153-3539;year=2015;volume=6;issue=1;spage=60;epage=60;aulast=Sarraj |
| _version_ | 1818234326939074560 |
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| author | Wafa M Sarraj Rong Tang Anas L Najjar Molly Griffin Anthony H Bui Alan Zambeli-Ljepovic Mike Senter-Zapata Maya Lewin-Berlin Leopoldo Fernandez Juliette Buckley Amy Ly Elena Brachtel Owen Aftreth John Gilbertson Yukako Yagi Michele Gadd Kevin S Hughes Barbara L Smith James S Michaelson |
| author_facet | Wafa M Sarraj Rong Tang Anas L Najjar Molly Griffin Anthony H Bui Alan Zambeli-Ljepovic Mike Senter-Zapata Maya Lewin-Berlin Leopoldo Fernandez Juliette Buckley Amy Ly Elena Brachtel Owen Aftreth John Gilbertson Yukako Yagi Michele Gadd Kevin S Hughes Barbara L Smith James S Michaelson |
| author_sort | Wafa M Sarraj |
| collection | DOAJ |
| description | Background: Histopathology is the only accepted method to measure and stage the breast tumor size. However, there is a need to find another method to measure and stage the tumor size when the pathological assessment is not available. Micro-computed tomography. (micro-CT) has the ability to measure tumor in three dimensions in an intact lumpectomy specimen. In this study, we aimed to determine the accuracy of micro-CT to measure and stage the primary tumor size in breast lumpectomy specimens, as compared to the histopathology. Materials and Methods: Seventy-two women who underwent lumpectomy surgery at the Massachusetts General Hospital Department of Surgery from June 2011 to September 2011, and from August 2013 to December 2013 participated in this study. The lumpectomy specimens were scanned using micro-CT followed by routine pathological processing. The maximum dimension of the invasive breast tumor was obtained from the micro-CT image and was compared to the corresponding pathology report for each subject. Results: The invasive tumor size measurement by micro-CT was underestimated in 24. cases. (33%), overestimated in 37. cases. (51%), and matched it exactly in 11. cases. (15%) compared to the histopathology measurement for all the cases. However, micro-CT T.stage classification differed from histopathology in only 11. (15.2%) with 6. cases. (8.3%) classified as a higher stage by micro-CT, and 5. cases. (6.9%) classified as lower compared to histopathology. In addition, micro-CT demonstrated a statically significant strong agreement (κ =0.6, P < 0.05) with pathological tumor size and staging for invasive ductal carcinoma. (IDC) group. In contrast, there was no agreement. (κ = .2, P = 0.67) between micro-CT and pathology in estimating and staging tumor size for invasive lobular carcinoma. (ILC) group. This could be explained by a small sample size. (7) for ILC group. Conclusions: Micro-CT is a promising modality for measuring and staging the IDC. |
| first_indexed | 2024-12-12T11:36:18Z |
| format | Article |
| id | doaj.art-04c93a940338451098de1a13a72577b3 |
| institution | Directory Open Access Journal |
| issn | 2153-3539 |
| language | English |
| last_indexed | 2024-12-12T11:36:18Z |
| publishDate | 2015-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Pathology Informatics |
| spelling | doaj.art-04c93a940338451098de1a13a72577b32022-12-22T00:25:38ZengElsevierJournal of Pathology Informatics2153-35392015-01-0161606010.4103/2153-3539.170647Prediction of primary breast cancer size and T-stage using micro-computed tomography in lumpectomy specimensWafa M SarrajRong TangAnas L NajjarMolly GriffinAnthony H BuiAlan Zambeli-LjepovicMike Senter-ZapataMaya Lewin-BerlinLeopoldo FernandezJuliette BuckleyAmy LyElena BrachtelOwen AftrethJohn GilbertsonYukako YagiMichele GaddKevin S HughesBarbara L SmithJames S MichaelsonBackground: Histopathology is the only accepted method to measure and stage the breast tumor size. However, there is a need to find another method to measure and stage the tumor size when the pathological assessment is not available. Micro-computed tomography. (micro-CT) has the ability to measure tumor in three dimensions in an intact lumpectomy specimen. In this study, we aimed to determine the accuracy of micro-CT to measure and stage the primary tumor size in breast lumpectomy specimens, as compared to the histopathology. Materials and Methods: Seventy-two women who underwent lumpectomy surgery at the Massachusetts General Hospital Department of Surgery from June 2011 to September 2011, and from August 2013 to December 2013 participated in this study. The lumpectomy specimens were scanned using micro-CT followed by routine pathological processing. The maximum dimension of the invasive breast tumor was obtained from the micro-CT image and was compared to the corresponding pathology report for each subject. Results: The invasive tumor size measurement by micro-CT was underestimated in 24. cases. (33%), overestimated in 37. cases. (51%), and matched it exactly in 11. cases. (15%) compared to the histopathology measurement for all the cases. However, micro-CT T.stage classification differed from histopathology in only 11. (15.2%) with 6. cases. (8.3%) classified as a higher stage by micro-CT, and 5. cases. (6.9%) classified as lower compared to histopathology. In addition, micro-CT demonstrated a statically significant strong agreement (κ =0.6, P < 0.05) with pathological tumor size and staging for invasive ductal carcinoma. (IDC) group. In contrast, there was no agreement. (κ = .2, P = 0.67) between micro-CT and pathology in estimating and staging tumor size for invasive lobular carcinoma. (ILC) group. This could be explained by a small sample size. (7) for ILC group. Conclusions: Micro-CT is a promising modality for measuring and staging the IDC.http://www.jpathinformatics.org/article.asp?issn=2153-3539;year=2015;volume=6;issue=1;spage=60;epage=60;aulast=SarrajBreast cancer, breast imaging, gross pathology, micro-computed tomography, tumor size |
| spellingShingle | Wafa M Sarraj Rong Tang Anas L Najjar Molly Griffin Anthony H Bui Alan Zambeli-Ljepovic Mike Senter-Zapata Maya Lewin-Berlin Leopoldo Fernandez Juliette Buckley Amy Ly Elena Brachtel Owen Aftreth John Gilbertson Yukako Yagi Michele Gadd Kevin S Hughes Barbara L Smith James S Michaelson Prediction of primary breast cancer size and T-stage using micro-computed tomography in lumpectomy specimens Journal of Pathology Informatics Breast cancer, breast imaging, gross pathology, micro-computed tomography, tumor size |
| title | Prediction of primary breast cancer size and T-stage using micro-computed tomography in lumpectomy specimens |
| title_full | Prediction of primary breast cancer size and T-stage using micro-computed tomography in lumpectomy specimens |
| title_fullStr | Prediction of primary breast cancer size and T-stage using micro-computed tomography in lumpectomy specimens |
| title_full_unstemmed | Prediction of primary breast cancer size and T-stage using micro-computed tomography in lumpectomy specimens |
| title_short | Prediction of primary breast cancer size and T-stage using micro-computed tomography in lumpectomy specimens |
| title_sort | prediction of primary breast cancer size and t stage using micro computed tomography in lumpectomy specimens |
| topic | Breast cancer, breast imaging, gross pathology, micro-computed tomography, tumor size |
| url | http://www.jpathinformatics.org/article.asp?issn=2153-3539;year=2015;volume=6;issue=1;spage=60;epage=60;aulast=Sarraj |
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