Behavioral, Anatomical and Heritable Convergence of Affect and Cognition in Superior Frontal Cortex
Cognitive abilities and affective experience are key human traits that are interrelated in behavior and brain. Individual variation of cognitive and affective traits, as well as brain structure, has been shown to partly underlie genetic effects. However, to what extent affect and cognition have a sh...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-11-01
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| Series: | NeuroImage |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S105381192100834X |
| _version_ | 1818826373046730752 |
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| author | Nevena Kraljević H. Lina Schaare Simon B. Eickhoff Peter Kochunov B.T. Thomas Yeo Shahrzad Kharabian Masouleh Sofie L. Valk |
| author_facet | Nevena Kraljević H. Lina Schaare Simon B. Eickhoff Peter Kochunov B.T. Thomas Yeo Shahrzad Kharabian Masouleh Sofie L. Valk |
| author_sort | Nevena Kraljević |
| collection | DOAJ |
| description | Cognitive abilities and affective experience are key human traits that are interrelated in behavior and brain. Individual variation of cognitive and affective traits, as well as brain structure, has been shown to partly underlie genetic effects. However, to what extent affect and cognition have a shared genetic relationship with local brain structure is incompletely understood. Here we studied phenotypic and genetic correlations of cognitive and affective traits in behavior and brain structure (cortical thickness, surface area and subcortical volumes) in the pedigree-based Human Connectome Project sample (N = 1091). Both cognitive and affective trait scores were highly heritable and showed significant phenotypic correlation on the behavioral level. Cortical thickness in the left superior frontal cortex showed a phenotypic association with both affect and cognition. Decomposing the phenotypic correlations into genetic and environmental components showed that the associations were accounted for by shared genetic effects between the traits. Quantitative functional decoding of the left superior frontal cortex further indicated that this region is associated with cognitive and emotional functioning. This study provides a multi-level approach to study the association between affect and cognition and suggests a convergence of both in superior frontal cortical thickness. |
| first_indexed | 2024-12-19T00:26:37Z |
| format | Article |
| id | doaj.art-04c9958543974d0c93a2f5687c63ce48 |
| institution | Directory Open Access Journal |
| issn | 1095-9572 |
| language | English |
| last_indexed | 2024-12-19T00:26:37Z |
| publishDate | 2021-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage |
| spelling | doaj.art-04c9958543974d0c93a2f5687c63ce482022-12-21T20:45:13ZengElsevierNeuroImage1095-95722021-11-01243118561Behavioral, Anatomical and Heritable Convergence of Affect and Cognition in Superior Frontal CortexNevena Kraljević0H. Lina Schaare1Simon B. Eickhoff2Peter Kochunov3B.T. Thomas Yeo4Shahrzad Kharabian Masouleh5Sofie L. Valk6Institute of Neuroscience and Medicine (INM-7: Brain and Behaviour), Research Centre Jülich, Jülich, Germany; Institute of Systems Neuroscience, Heinrich Heine University Düsseldorf, Düsseldorf, GermanyInstitute of Neuroscience and Medicine (INM-7: Brain and Behaviour), Research Centre Jülich, Jülich, Germany; Otto Hahn group Cognitive Neurogenetics, Max Planck Institute for Human Cognitive and Brain Sciences, Stephanstr. 1A, Leipzig 04103, Germany; Corresponding authors at: Institute of Neuroscience and Medicine (INM-7: Brain and Behaviour), Research Centre Jülich, Jülich, Germany.Institute of Neuroscience and Medicine (INM-7: Brain and Behaviour), Research Centre Jülich, Jülich, Germany; Institute of Systems Neuroscience, Heinrich Heine University Düsseldorf, Düsseldorf, GermanyMaryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, MD, USADepartment of Electrical and Computer Engineering, Centre for Sleep and Cognition, Centre for Translational MR Research, N.1 Institute for Health and Institute for Digital Medicine, National University of Singapore, Singapore; Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA; NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, SingaporeInstitute of Neuroscience and Medicine (INM-7: Brain and Behaviour), Research Centre Jülich, Jülich, Germany; Institute of Systems Neuroscience, Heinrich Heine University Düsseldorf, Düsseldorf, GermanyInstitute of Neuroscience and Medicine (INM-7: Brain and Behaviour), Research Centre Jülich, Jülich, Germany; Institute of Systems Neuroscience, Heinrich Heine University Düsseldorf, Düsseldorf, Germany; Otto Hahn group Cognitive Neurogenetics, Max Planck Institute for Human Cognitive and Brain Sciences, Stephanstr. 1A, Leipzig 04103, Germany; Corresponding authors at: Institute of Neuroscience and Medicine (INM-7: Brain and Behaviour), Research Centre Jülich, Jülich, Germany.Cognitive abilities and affective experience are key human traits that are interrelated in behavior and brain. Individual variation of cognitive and affective traits, as well as brain structure, has been shown to partly underlie genetic effects. However, to what extent affect and cognition have a shared genetic relationship with local brain structure is incompletely understood. Here we studied phenotypic and genetic correlations of cognitive and affective traits in behavior and brain structure (cortical thickness, surface area and subcortical volumes) in the pedigree-based Human Connectome Project sample (N = 1091). Both cognitive and affective trait scores were highly heritable and showed significant phenotypic correlation on the behavioral level. Cortical thickness in the left superior frontal cortex showed a phenotypic association with both affect and cognition. Decomposing the phenotypic correlations into genetic and environmental components showed that the associations were accounted for by shared genetic effects between the traits. Quantitative functional decoding of the left superior frontal cortex further indicated that this region is associated with cognitive and emotional functioning. This study provides a multi-level approach to study the association between affect and cognition and suggests a convergence of both in superior frontal cortical thickness.http://www.sciencedirect.com/science/article/pii/S105381192100834XAffectCognitionHeritabilityFrontal cortexCortical structureGenetic correlation |
| spellingShingle | Nevena Kraljević H. Lina Schaare Simon B. Eickhoff Peter Kochunov B.T. Thomas Yeo Shahrzad Kharabian Masouleh Sofie L. Valk Behavioral, Anatomical and Heritable Convergence of Affect and Cognition in Superior Frontal Cortex NeuroImage Affect Cognition Heritability Frontal cortex Cortical structure Genetic correlation |
| title | Behavioral, Anatomical and Heritable Convergence of Affect and Cognition in Superior Frontal Cortex |
| title_full | Behavioral, Anatomical and Heritable Convergence of Affect and Cognition in Superior Frontal Cortex |
| title_fullStr | Behavioral, Anatomical and Heritable Convergence of Affect and Cognition in Superior Frontal Cortex |
| title_full_unstemmed | Behavioral, Anatomical and Heritable Convergence of Affect and Cognition in Superior Frontal Cortex |
| title_short | Behavioral, Anatomical and Heritable Convergence of Affect and Cognition in Superior Frontal Cortex |
| title_sort | behavioral anatomical and heritable convergence of affect and cognition in superior frontal cortex |
| topic | Affect Cognition Heritability Frontal cortex Cortical structure Genetic correlation |
| url | http://www.sciencedirect.com/science/article/pii/S105381192100834X |
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