Folding Control in the Path of Type 5 Secretion
The type 5 secretion system (T5SS) is one of the more widespread secretion systems in Gram-negative bacteria. Proteins secreted by the T5SS are functionally diverse (toxins, adhesins, enzymes) and include numerous virulence factors. Mechanistically, the T5SS has long been considered the simplest of...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-05-01
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| Series: | Toxins |
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| Online Access: | https://www.mdpi.com/2072-6651/13/5/341 |
| _version_ | 1797534633764585472 |
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| author | Nathalie Dautin |
| author_facet | Nathalie Dautin |
| author_sort | Nathalie Dautin |
| collection | DOAJ |
| description | The type 5 secretion system (T5SS) is one of the more widespread secretion systems in Gram-negative bacteria. Proteins secreted by the T5SS are functionally diverse (toxins, adhesins, enzymes) and include numerous virulence factors. Mechanistically, the T5SS has long been considered the simplest of secretion systems, due to the paucity of proteins required for its functioning. Still, despite more than two decades of study, the exact process by which T5SS substrates attain their final destination and correct conformation is not totally deciphered. Moreover, the recent addition of new sub-families to the T5SS raises additional questions about this secretion mechanism. Central to the understanding of type 5 secretion is the question of protein folding, which needs to be carefully controlled in each of the bacterial cell compartments these proteins cross. Here, the biogenesis of proteins secreted by the Type 5 secretion system is discussed, with a focus on the various factors preventing or promoting protein folding during biogenesis. |
| first_indexed | 2024-03-10T11:32:19Z |
| format | Article |
| id | doaj.art-04c9b2af921c4e8e8208744908a74d6e |
| institution | Directory Open Access Journal |
| issn | 2072-6651 |
| language | English |
| last_indexed | 2024-03-10T11:32:19Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxins |
| spelling | doaj.art-04c9b2af921c4e8e8208744908a74d6e2023-11-21T19:06:25ZengMDPI AGToxins2072-66512021-05-0113534110.3390/toxins13050341Folding Control in the Path of Type 5 SecretionNathalie Dautin0Laboratoire de Biologie Physico-Chimique des Protéines Membranaires, Université de Paris, LBPC-PM, CNRS, UMR7099, 75005 Paris, FranceThe type 5 secretion system (T5SS) is one of the more widespread secretion systems in Gram-negative bacteria. Proteins secreted by the T5SS are functionally diverse (toxins, adhesins, enzymes) and include numerous virulence factors. Mechanistically, the T5SS has long been considered the simplest of secretion systems, due to the paucity of proteins required for its functioning. Still, despite more than two decades of study, the exact process by which T5SS substrates attain their final destination and correct conformation is not totally deciphered. Moreover, the recent addition of new sub-families to the T5SS raises additional questions about this secretion mechanism. Central to the understanding of type 5 secretion is the question of protein folding, which needs to be carefully controlled in each of the bacterial cell compartments these proteins cross. Here, the biogenesis of proteins secreted by the Type 5 secretion system is discussed, with a focus on the various factors preventing or promoting protein folding during biogenesis.https://www.mdpi.com/2072-6651/13/5/341secretionfoldingautotransportertype 5 secretion systemintimininvasin |
| spellingShingle | Nathalie Dautin Folding Control in the Path of Type 5 Secretion Toxins secretion folding autotransporter type 5 secretion system intimin invasin |
| title | Folding Control in the Path of Type 5 Secretion |
| title_full | Folding Control in the Path of Type 5 Secretion |
| title_fullStr | Folding Control in the Path of Type 5 Secretion |
| title_full_unstemmed | Folding Control in the Path of Type 5 Secretion |
| title_short | Folding Control in the Path of Type 5 Secretion |
| title_sort | folding control in the path of type 5 secretion |
| topic | secretion folding autotransporter type 5 secretion system intimin invasin |
| url | https://www.mdpi.com/2072-6651/13/5/341 |
| work_keys_str_mv | AT nathaliedautin foldingcontrolinthepathoftype5secretion |