Evaluation of FDG-PET/CT Use in Children with Suspected Infection or Inflammation
[<sup>18</sup>F]-FDG-PET/CT ([<sup>18</sup>F]-fluoro-deoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT)) is increasingly used as a diagnostic tool in suspected infectious or inflammatory conditions. Studies on the value of FDG-PET/CT in children are...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-09-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/10/9/715 |
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| author | Fabienne G. Ropers Robin M. P. van Mossevelde Chantal P. Bleeker-Rovers Floris H. P. van Velden Danielle M. E. van Assema Judit A. Adam Marnix G. E. H. Lam Nelleke Tolboom Olaf M. Dekkers Lioe-Fee de Geus-Oei Virginie Frings |
| author_facet | Fabienne G. Ropers Robin M. P. van Mossevelde Chantal P. Bleeker-Rovers Floris H. P. van Velden Danielle M. E. van Assema Judit A. Adam Marnix G. E. H. Lam Nelleke Tolboom Olaf M. Dekkers Lioe-Fee de Geus-Oei Virginie Frings |
| author_sort | Fabienne G. Ropers |
| collection | DOAJ |
| description | [<sup>18</sup>F]-FDG-PET/CT ([<sup>18</sup>F]-fluoro-deoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT)) is increasingly used as a diagnostic tool in suspected infectious or inflammatory conditions. Studies on the value of FDG-PET/CT in children are scarce. This study assesses the role of FDG-PET/CT in suspected infection or inflammation in children. In this multicenter cohort study, 64 scans in 59 children with suspected infection or inflammation were selected from 452 pediatric FDG-PET/CT scans, performed in five hospitals between January 2016 and August 2017. Main outcomes were diagnostic information provided by FDG-PET/CT for diagnostic scans and impact on clinical management for follow-up scans. Of these 64 scans, 50 were performed for primary diagnosis and 14 to monitor disease activity. Of the positive diagnostic scans, 23/27 (85%) contributed to establishing a diagnosis. Of the negative diagnostic scans, 8/21 (38%) contributed to the final diagnosis by narrowing the differential or by providing information on the disease manifestation. In all follow-up scans, FDG-PET/CT results guided management decisions. CRP was significantly higher in positive scans than in negative scans (<i>p</i> = 0.004). In 6% of diagnostic scans, relevant incidental findings were identified. In conclusion, FDG-PET/CT performed in children with suspected infection or inflammation resulted in information that contributed to the final diagnosis or helped to guide management decisions in the majority of cases. Prospective studies assessing the impact of FDG-PET/CT results on diagnosis and patient management using a structured diagnostic protocol are feasible and necessary. |
| first_indexed | 2024-03-10T16:13:12Z |
| format | Article |
| id | doaj.art-04cb46518645491aa7aa976179b290ef |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-10T16:13:12Z |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-04cb46518645491aa7aa976179b290ef2023-11-20T14:13:27ZengMDPI AGDiagnostics2075-44182020-09-0110971510.3390/diagnostics10090715Evaluation of FDG-PET/CT Use in Children with Suspected Infection or InflammationFabienne G. Ropers0Robin M. P. van Mossevelde1Chantal P. Bleeker-Rovers2Floris H. P. van Velden3Danielle M. E. van Assema4Judit A. Adam5Marnix G. E. H. Lam6Nelleke Tolboom7Olaf M. Dekkers8Lioe-Fee de Geus-Oei9Virginie Frings10Department of Pediatrics, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The NetherlandsDepartment of Pediatrics, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The NetherlandsDepartment of Internal Medicine, Radboud University Medical Center, Geert Grooteplein Zuid 10, 6525 GA Nijmegen, The NetherlandsSection of Nuclear Medicine, Department of Radiology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The NetherlandsDepartment of Radiology and Nuclear Medicine, Erasmus Medical Center, Dr. Molewaterplein 40, 3015 GD Rotterdam, The NetherlandsDepartment of Radiology and Nuclear Medicine, Amsterdam UMC, Meibergdreef 9, 1105 AZ Amsterdam, The NetherlandsDepartment of Radiology and Nuclear Medicine, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The NetherlandsDepartment of Radiology and Nuclear Medicine, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The NetherlandsDepartment of Clinical Epidemiology and Endocrinology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The NetherlandsSection of Nuclear Medicine, Department of Radiology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The NetherlandsDepartment of Pediatrics, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands[<sup>18</sup>F]-FDG-PET/CT ([<sup>18</sup>F]-fluoro-deoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT)) is increasingly used as a diagnostic tool in suspected infectious or inflammatory conditions. Studies on the value of FDG-PET/CT in children are scarce. This study assesses the role of FDG-PET/CT in suspected infection or inflammation in children. In this multicenter cohort study, 64 scans in 59 children with suspected infection or inflammation were selected from 452 pediatric FDG-PET/CT scans, performed in five hospitals between January 2016 and August 2017. Main outcomes were diagnostic information provided by FDG-PET/CT for diagnostic scans and impact on clinical management for follow-up scans. Of these 64 scans, 50 were performed for primary diagnosis and 14 to monitor disease activity. Of the positive diagnostic scans, 23/27 (85%) contributed to establishing a diagnosis. Of the negative diagnostic scans, 8/21 (38%) contributed to the final diagnosis by narrowing the differential or by providing information on the disease manifestation. In all follow-up scans, FDG-PET/CT results guided management decisions. CRP was significantly higher in positive scans than in negative scans (<i>p</i> = 0.004). In 6% of diagnostic scans, relevant incidental findings were identified. In conclusion, FDG-PET/CT performed in children with suspected infection or inflammation resulted in information that contributed to the final diagnosis or helped to guide management decisions in the majority of cases. Prospective studies assessing the impact of FDG-PET/CT results on diagnosis and patient management using a structured diagnostic protocol are feasible and necessary.https://www.mdpi.com/2075-4418/10/9/715FDG-PET/CTpediatricsinfectioninflammationdiagnostic valuediagnostic information |
| spellingShingle | Fabienne G. Ropers Robin M. P. van Mossevelde Chantal P. Bleeker-Rovers Floris H. P. van Velden Danielle M. E. van Assema Judit A. Adam Marnix G. E. H. Lam Nelleke Tolboom Olaf M. Dekkers Lioe-Fee de Geus-Oei Virginie Frings Evaluation of FDG-PET/CT Use in Children with Suspected Infection or Inflammation Diagnostics FDG-PET/CT pediatrics infection inflammation diagnostic value diagnostic information |
| title | Evaluation of FDG-PET/CT Use in Children with Suspected Infection or Inflammation |
| title_full | Evaluation of FDG-PET/CT Use in Children with Suspected Infection or Inflammation |
| title_fullStr | Evaluation of FDG-PET/CT Use in Children with Suspected Infection or Inflammation |
| title_full_unstemmed | Evaluation of FDG-PET/CT Use in Children with Suspected Infection or Inflammation |
| title_short | Evaluation of FDG-PET/CT Use in Children with Suspected Infection or Inflammation |
| title_sort | evaluation of fdg pet ct use in children with suspected infection or inflammation |
| topic | FDG-PET/CT pediatrics infection inflammation diagnostic value diagnostic information |
| url | https://www.mdpi.com/2075-4418/10/9/715 |
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