| Summary: | Antibiotic-sparing treatments are required to prevent the further emergence of antimicrobial resistance in <i>Neisseria gonorrhoeae</i>. Commensal <i>Neisseria</i> species have previously been found to inhibit the growth of pathogenic <i>Neisseria</i> species. For example, a previous study found that three out of five historical isolates of <i>Neisseria mucosa</i> could inhibit the growth of <i>N. gonorrhoeae</i>. In this study, we used agar overlay assays to assess if 24 circulating and historical isolates of <i>Neisseria mucosa</i> could inhibit the growth of 28 circulating and historical isolates of <i>N. gonorrhoeae</i>. Although pitting around each colony of <i>N. mucosa</i> created an optical illusion of decreased growth of <i>N. gonorrhoeae</i>, we found no evidence of inhibition (n = 24). In contrast, positive controls of <i>Streptococcus pneumoniae</i> and <i>Escherichia coli</i> demonstrated a strong inhibitory effect against the growth of <i>N. gonorrhoeae.</i>
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