<i>Neisseria mucosa</i> Does Not Inhibit the Growth of <i>Neisseria gonorrhoeae</i>
Antibiotic-sparing treatments are required to prevent the further emergence of antimicrobial resistance in <i>Neisseria gonorrhoeae</i>. Commensal <i>Neisseria</i> species have previously been found to inhibit the growth of pathogenic <i>Neisseria</i> species. For...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-02-01
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| Series: | Sci |
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| Online Access: | https://www.mdpi.com/2413-4155/4/1/8 |
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| author | Saïd Abdellati Jolein Laumen Natalia Gonzalez Sheeba S. Manoharan-Basil Christophe Van Dijck Irith De Baetselier Delphine Martiny Tessa de Block Chris Kenyon |
| author_facet | Saïd Abdellati Jolein Laumen Natalia Gonzalez Sheeba S. Manoharan-Basil Christophe Van Dijck Irith De Baetselier Delphine Martiny Tessa de Block Chris Kenyon |
| author_sort | Saïd Abdellati |
| collection | DOAJ |
| description | Antibiotic-sparing treatments are required to prevent the further emergence of antimicrobial resistance in <i>Neisseria gonorrhoeae</i>. Commensal <i>Neisseria</i> species have previously been found to inhibit the growth of pathogenic <i>Neisseria</i> species. For example, a previous study found that three out of five historical isolates of <i>Neisseria mucosa</i> could inhibit the growth of <i>N. gonorrhoeae</i>. In this study, we used agar overlay assays to assess if 24 circulating and historical isolates of <i>Neisseria mucosa</i> could inhibit the growth of 28 circulating and historical isolates of <i>N. gonorrhoeae</i>. Although pitting around each colony of <i>N. mucosa</i> created an optical illusion of decreased growth of <i>N. gonorrhoeae</i>, we found no evidence of inhibition (n = 24). In contrast, positive controls of <i>Streptococcus pneumoniae</i> and <i>Escherichia coli</i> demonstrated a strong inhibitory effect against the growth of <i>N. gonorrhoeae.</i> |
| first_indexed | 2024-03-09T12:42:27Z |
| format | Article |
| id | doaj.art-04cd5673e1c84d8fa0a85f4e440479f4 |
| institution | Directory Open Access Journal |
| issn | 2413-4155 |
| language | English |
| last_indexed | 2024-03-09T12:42:27Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Sci |
| spelling | doaj.art-04cd5673e1c84d8fa0a85f4e440479f42023-11-30T22:15:35ZengMDPI AGSci2413-41552022-02-0141810.3390/sci4010008<i>Neisseria mucosa</i> Does Not Inhibit the Growth of <i>Neisseria gonorrhoeae</i>Saïd Abdellati0Jolein Laumen1Natalia Gonzalez2Sheeba S. Manoharan-Basil3Christophe Van Dijck4Irith De Baetselier5Delphine Martiny6Tessa de Block7Chris Kenyon8HIV/STI Unit, Institute of Tropical Medicine, 2000 Antwerp, BelgiumHIV/STI Unit, Institute of Tropical Medicine, 2000 Antwerp, BelgiumHIV/STI Unit, Institute of Tropical Medicine, 2000 Antwerp, BelgiumHIV/STI Unit, Institute of Tropical Medicine, 2000 Antwerp, BelgiumHIV/STI Unit, Institute of Tropical Medicine, 2000 Antwerp, BelgiumHIV/STI Unit, Institute of Tropical Medicine, 2000 Antwerp, BelgiumMicrobiology Department, Laboratoire Hospitalier Universitaire de Bruxelles, 1060 Brussels, BelgiumHIV/STI Unit, Institute of Tropical Medicine, 2000 Antwerp, BelgiumHIV/STI Unit, Institute of Tropical Medicine, 2000 Antwerp, BelgiumAntibiotic-sparing treatments are required to prevent the further emergence of antimicrobial resistance in <i>Neisseria gonorrhoeae</i>. Commensal <i>Neisseria</i> species have previously been found to inhibit the growth of pathogenic <i>Neisseria</i> species. For example, a previous study found that three out of five historical isolates of <i>Neisseria mucosa</i> could inhibit the growth of <i>N. gonorrhoeae</i>. In this study, we used agar overlay assays to assess if 24 circulating and historical isolates of <i>Neisseria mucosa</i> could inhibit the growth of 28 circulating and historical isolates of <i>N. gonorrhoeae</i>. Although pitting around each colony of <i>N. mucosa</i> created an optical illusion of decreased growth of <i>N. gonorrhoeae</i>, we found no evidence of inhibition (n = 24). In contrast, positive controls of <i>Streptococcus pneumoniae</i> and <i>Escherichia coli</i> demonstrated a strong inhibitory effect against the growth of <i>N. gonorrhoeae.</i>https://www.mdpi.com/2413-4155/4/1/8<i>Neisseria mucosa</i><i>Neisseria gonorrhoeae</i>agar overlay assaybacterial competition |
| spellingShingle | Saïd Abdellati Jolein Laumen Natalia Gonzalez Sheeba S. Manoharan-Basil Christophe Van Dijck Irith De Baetselier Delphine Martiny Tessa de Block Chris Kenyon <i>Neisseria mucosa</i> Does Not Inhibit the Growth of <i>Neisseria gonorrhoeae</i> Sci <i>Neisseria mucosa</i> <i>Neisseria gonorrhoeae</i> agar overlay assay bacterial competition |
| title | <i>Neisseria mucosa</i> Does Not Inhibit the Growth of <i>Neisseria gonorrhoeae</i> |
| title_full | <i>Neisseria mucosa</i> Does Not Inhibit the Growth of <i>Neisseria gonorrhoeae</i> |
| title_fullStr | <i>Neisseria mucosa</i> Does Not Inhibit the Growth of <i>Neisseria gonorrhoeae</i> |
| title_full_unstemmed | <i>Neisseria mucosa</i> Does Not Inhibit the Growth of <i>Neisseria gonorrhoeae</i> |
| title_short | <i>Neisseria mucosa</i> Does Not Inhibit the Growth of <i>Neisseria gonorrhoeae</i> |
| title_sort | i neisseria mucosa i does not inhibit the growth of i neisseria gonorrhoeae i |
| topic | <i>Neisseria mucosa</i> <i>Neisseria gonorrhoeae</i> agar overlay assay bacterial competition |
| url | https://www.mdpi.com/2413-4155/4/1/8 |
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