Effect of Cannabidiol (CBD) on Canine Inflammatory Response: An Ex Vivo Study on LPS Stimulated Whole Blood
The use of cannabidiol (CBD) for animal species is an area of growing interest, for example for its anti-inflammatory and immuno-modulating properties, even though all of its biological effects are still not fully understood, especially in veterinary medicine. Therefore, the aim of this study was to...
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MDPI AG
2021-09-01
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Series: | Veterinary Sciences |
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Online Access: | https://www.mdpi.com/2306-7381/8/9/185 |
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author | Enrico Gugliandolo Patrizia Licata Alessio Filippo Peritore Rosalba Siracusa Ramona D’Amico Marika Cordaro Roberta Fusco Daniela Impellizzeri Rosanna Di Paola Salvatore Cuzzocrea Rosalia Crupi Claudia Dina Interlandi |
author_facet | Enrico Gugliandolo Patrizia Licata Alessio Filippo Peritore Rosalba Siracusa Ramona D’Amico Marika Cordaro Roberta Fusco Daniela Impellizzeri Rosanna Di Paola Salvatore Cuzzocrea Rosalia Crupi Claudia Dina Interlandi |
author_sort | Enrico Gugliandolo |
collection | DOAJ |
description | The use of cannabidiol (CBD) for animal species is an area of growing interest, for example for its anti-inflammatory and immuno-modulating properties, even though all of its biological effects are still not fully understood, especially in veterinary medicine. Therefore, the aim of this study was to investigate the anti-inflammatory and immuno-modulating properties of CBD for the first time directly in canine inflammatory response. We used an ex vivo model of LPS-stimulated whole dog blood. We stimulated the whole blood from healthy dogs with LPS 100 ng/mL for 24 h in the presence or not of CBD 50 and 100 μg/mL. We observed a reduction in IL-6 and TNF-α production from the group treated with CBD, but non-altered IL-10 levels. Moreover, we also observed from the CBD-treated group a reduction in Nf-κB and COX-2 expression. In conclusion, we demonstrated for the first time the anti-inflammatory and immuno-modulating properties of CBD directly in dogs’ immune cells, using a canine ex vivo inflammatory model. The results obtained from these studies encourage further studies to better understand the possible therapeutic role of CBD in veterinary medicine. |
first_indexed | 2024-03-10T07:08:16Z |
format | Article |
id | doaj.art-04cdae20d29a48a09fdd92fd1c2ea272 |
institution | Directory Open Access Journal |
issn | 2306-7381 |
language | English |
last_indexed | 2024-03-10T07:08:16Z |
publishDate | 2021-09-01 |
publisher | MDPI AG |
record_format | Article |
series | Veterinary Sciences |
spelling | doaj.art-04cdae20d29a48a09fdd92fd1c2ea2722023-11-22T15:35:52ZengMDPI AGVeterinary Sciences2306-73812021-09-018918510.3390/vetsci8090185Effect of Cannabidiol (CBD) on Canine Inflammatory Response: An Ex Vivo Study on LPS Stimulated Whole BloodEnrico Gugliandolo0Patrizia Licata1Alessio Filippo Peritore2Rosalba Siracusa3Ramona D’Amico4Marika Cordaro5Roberta Fusco6Daniela Impellizzeri7Rosanna Di Paola8Salvatore Cuzzocrea9Rosalia Crupi10Claudia Dina Interlandi11Department of Veterinary Science, University of Messina, 98166 Messina, ItalyDepartment of Veterinary Science, University of Messina, 98166 Messina, ItalyDepartment of Chemical, Biological, Pharmaceutical, and Environmental Science, University of Messina, 98166 Messina, ItalyDepartment of Chemical, Biological, Pharmaceutical, and Environmental Science, University of Messina, 98166 Messina, ItalyDepartment of Chemical, Biological, Pharmaceutical, and Environmental Science, University of Messina, 98166 Messina, ItalyDepartment of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, 98166 Messina, ItalyDepartment of Chemical, Biological, Pharmaceutical, and Environmental Science, University of Messina, 98166 Messina, ItalyDepartment of Chemical, Biological, Pharmaceutical, and Environmental Science, University of Messina, 98166 Messina, ItalyDepartment of Chemical, Biological, Pharmaceutical, and Environmental Science, University of Messina, 98166 Messina, ItalyDepartment of Chemical, Biological, Pharmaceutical, and Environmental Science, University of Messina, 98166 Messina, ItalyDepartment of Veterinary Science, University of Messina, 98166 Messina, ItalyDepartment of Veterinary Science, University of Messina, 98166 Messina, ItalyThe use of cannabidiol (CBD) for animal species is an area of growing interest, for example for its anti-inflammatory and immuno-modulating properties, even though all of its biological effects are still not fully understood, especially in veterinary medicine. Therefore, the aim of this study was to investigate the anti-inflammatory and immuno-modulating properties of CBD for the first time directly in canine inflammatory response. We used an ex vivo model of LPS-stimulated whole dog blood. We stimulated the whole blood from healthy dogs with LPS 100 ng/mL for 24 h in the presence or not of CBD 50 and 100 μg/mL. We observed a reduction in IL-6 and TNF-α production from the group treated with CBD, but non-altered IL-10 levels. Moreover, we also observed from the CBD-treated group a reduction in Nf-κB and COX-2 expression. In conclusion, we demonstrated for the first time the anti-inflammatory and immuno-modulating properties of CBD directly in dogs’ immune cells, using a canine ex vivo inflammatory model. The results obtained from these studies encourage further studies to better understand the possible therapeutic role of CBD in veterinary medicine.https://www.mdpi.com/2306-7381/8/9/185cannabidiolex vivowhole dog bloodcanine inflammatory response |
spellingShingle | Enrico Gugliandolo Patrizia Licata Alessio Filippo Peritore Rosalba Siracusa Ramona D’Amico Marika Cordaro Roberta Fusco Daniela Impellizzeri Rosanna Di Paola Salvatore Cuzzocrea Rosalia Crupi Claudia Dina Interlandi Effect of Cannabidiol (CBD) on Canine Inflammatory Response: An Ex Vivo Study on LPS Stimulated Whole Blood Veterinary Sciences cannabidiol ex vivo whole dog blood canine inflammatory response |
title | Effect of Cannabidiol (CBD) on Canine Inflammatory Response: An Ex Vivo Study on LPS Stimulated Whole Blood |
title_full | Effect of Cannabidiol (CBD) on Canine Inflammatory Response: An Ex Vivo Study on LPS Stimulated Whole Blood |
title_fullStr | Effect of Cannabidiol (CBD) on Canine Inflammatory Response: An Ex Vivo Study on LPS Stimulated Whole Blood |
title_full_unstemmed | Effect of Cannabidiol (CBD) on Canine Inflammatory Response: An Ex Vivo Study on LPS Stimulated Whole Blood |
title_short | Effect of Cannabidiol (CBD) on Canine Inflammatory Response: An Ex Vivo Study on LPS Stimulated Whole Blood |
title_sort | effect of cannabidiol cbd on canine inflammatory response an ex vivo study on lps stimulated whole blood |
topic | cannabidiol ex vivo whole dog blood canine inflammatory response |
url | https://www.mdpi.com/2306-7381/8/9/185 |
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