Role of GD3 Synthase ST8Sia I in Cancers
GD3 synthase controls the biosynthesis of complex gangliosides, bearing two or more sialic acid residues. Disialylated gangliosides GD3 and GD2 are tumor-associated carbohydrate antigens (TACA) in neuro–ectoderm-derived cancers, and are directly involved in cell malignant properties, i.e., migration...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-03-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/14/5/1299 |
| _version_ | 1797475451651751936 |
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| author | Angelina Kasprowicz Groux-Degroote Sophie Chann Lagadec Philippe Delannoy |
| author_facet | Angelina Kasprowicz Groux-Degroote Sophie Chann Lagadec Philippe Delannoy |
| author_sort | Angelina Kasprowicz |
| collection | DOAJ |
| description | GD3 synthase controls the biosynthesis of complex gangliosides, bearing two or more sialic acid residues. Disialylated gangliosides GD3 and GD2 are tumor-associated carbohydrate antigens (TACA) in neuro–ectoderm-derived cancers, and are directly involved in cell malignant properties, i.e., migration, invasion, stemness, and epithelial–mesenchymal transition. Since GD3 and GD2 levels are directly linked to GD3 synthase expression and activity, targeting GD3 synthase appears to be a promising strategy through which to interfere with ganglioside-associated malignant properties. We review here the current knowledge on GD3 synthase expression and regulation in cancers, and the consequences of complex ganglioside expression on cancer cell signaling and properties, highlighting the relationships between GD3 synthase expression and epithelial–mesenchymal transition and stemness. Different strategies were used to modulate GD3 synthase expression in cancer cells in vitro and in animal models, such as inhibitors or siRNA/lncRNA, which efficiently reduced cancer cell malignant properties and the proportion of GD2 positive cancer stem cells, which are associated with high metastatic properties, resistance to therapy, and cancer relapse. These data show the relevance of targeting GD3 synthase in association with conventional therapies, to decrease the number of cancer stem cells in tumors. |
| first_indexed | 2024-03-09T20:44:19Z |
| format | Article |
| id | doaj.art-04cf27b3823d43f7bb68d835455fd7d4 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T20:44:19Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-04cf27b3823d43f7bb68d835455fd7d42023-11-23T22:48:53ZengMDPI AGCancers2072-66942022-03-01145129910.3390/cancers14051299Role of GD3 Synthase ST8Sia I in CancersAngelina Kasprowicz0Groux-Degroote Sophie1Chann Lagadec2Philippe Delannoy3University of Lille, CNRS, UMR 8576-UGSF-Unité de Glycosylation Structurale et Fonctionnelle, F-59000 Lille, FranceUniversity of Lille, CNRS, UMR 8576-UGSF-Unité de Glycosylation Structurale et Fonctionnelle, F-59000 Lille, FranceUniversity of Lille, CNRS, Inserm, CHU Lille UMR9020-U1277-CANTHER Cancer Heterogeneity, Plasticity and Resistance to Therapies, F-59000 Lille, FranceUniversity of Lille, CNRS, UMR 8576-UGSF-Unité de Glycosylation Structurale et Fonctionnelle, F-59000 Lille, FranceGD3 synthase controls the biosynthesis of complex gangliosides, bearing two or more sialic acid residues. Disialylated gangliosides GD3 and GD2 are tumor-associated carbohydrate antigens (TACA) in neuro–ectoderm-derived cancers, and are directly involved in cell malignant properties, i.e., migration, invasion, stemness, and epithelial–mesenchymal transition. Since GD3 and GD2 levels are directly linked to GD3 synthase expression and activity, targeting GD3 synthase appears to be a promising strategy through which to interfere with ganglioside-associated malignant properties. We review here the current knowledge on GD3 synthase expression and regulation in cancers, and the consequences of complex ganglioside expression on cancer cell signaling and properties, highlighting the relationships between GD3 synthase expression and epithelial–mesenchymal transition and stemness. Different strategies were used to modulate GD3 synthase expression in cancer cells in vitro and in animal models, such as inhibitors or siRNA/lncRNA, which efficiently reduced cancer cell malignant properties and the proportion of GD2 positive cancer stem cells, which are associated with high metastatic properties, resistance to therapy, and cancer relapse. These data show the relevance of targeting GD3 synthase in association with conventional therapies, to decrease the number of cancer stem cells in tumors.https://www.mdpi.com/2072-6694/14/5/1299gangliosideGD3 synthaseepithelial–mesenchymal transitiontranscriptional regulation |
| spellingShingle | Angelina Kasprowicz Groux-Degroote Sophie Chann Lagadec Philippe Delannoy Role of GD3 Synthase ST8Sia I in Cancers Cancers ganglioside GD3 synthase epithelial–mesenchymal transition transcriptional regulation |
| title | Role of GD3 Synthase ST8Sia I in Cancers |
| title_full | Role of GD3 Synthase ST8Sia I in Cancers |
| title_fullStr | Role of GD3 Synthase ST8Sia I in Cancers |
| title_full_unstemmed | Role of GD3 Synthase ST8Sia I in Cancers |
| title_short | Role of GD3 Synthase ST8Sia I in Cancers |
| title_sort | role of gd3 synthase st8sia i in cancers |
| topic | ganglioside GD3 synthase epithelial–mesenchymal transition transcriptional regulation |
| url | https://www.mdpi.com/2072-6694/14/5/1299 |
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