The View of Pediatric Nephrotic Syndrome as a Podocytopathy
Nephrotic syndrome (NS) is a complex clinical entity characterized by proteinuria, hypoalbuminemia, and edema. In this review, we propose the view of NS as a podocytopathy, highlighting the importance of understanding the role of podocytes in the development of this condition. We discuss the various...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-12-01
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| Series: | Kidney and Dialysis |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2673-8236/3/4/30 |
| _version_ | 1827574387720585216 |
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| author | Pedro Alves Soares Vaz de Castro Thomas Fujihara Ide Fernando Crespo Torres Ana Cristina Simões e Silva |
| author_facet | Pedro Alves Soares Vaz de Castro Thomas Fujihara Ide Fernando Crespo Torres Ana Cristina Simões e Silva |
| author_sort | Pedro Alves Soares Vaz de Castro |
| collection | DOAJ |
| description | Nephrotic syndrome (NS) is a complex clinical entity characterized by proteinuria, hypoalbuminemia, and edema. In this review, we propose the view of NS as a podocytopathy, highlighting the importance of understanding the role of podocytes in the development of this condition. We discuss the various etiologies of NS, ranging from congenital to primary renal diseases, as well as secondary forms due to systemic diseases. We also delve into the mechanisms underlying podocyte injury, which plays a crucial role in the development of NS. By viewing NS as a podocytopathy, we suggest potential implications for the diagnosis and treatment of this condition, including the use of podocyte-specific biomarkers and targeted therapies. Our review provides a comprehensive overview of NS and its underlying mechanisms, emphasizing the importance of a multidisciplinary approach to the diagnosis and management of this condition. Further research is essential to better understand the complex interplay between podocyte injury and the development of NS, with the ultimate goal of improving patient outcomes. |
| first_indexed | 2024-03-08T20:36:26Z |
| format | Article |
| id | doaj.art-04d00f81276542dca9170e853334d97e |
| institution | Directory Open Access Journal |
| issn | 2673-8236 |
| language | English |
| last_indexed | 2024-03-08T20:36:26Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Kidney and Dialysis |
| spelling | doaj.art-04d00f81276542dca9170e853334d97e2023-12-22T14:20:20ZengMDPI AGKidney and Dialysis2673-82362023-12-013434637210.3390/kidneydial3040030The View of Pediatric Nephrotic Syndrome as a PodocytopathyPedro Alves Soares Vaz de Castro0Thomas Fujihara Ide1Fernando Crespo Torres2Ana Cristina Simões e Silva3Interdisciplinary Laboratory of Medical Investigation, Unit of Pediatric Nephrology, Faculty of Medicine, Federal University of Minas Gerais (UFMG), Belo Horizonte 30130-100, BrazilInterdisciplinary Laboratory of Medical Investigation, Unit of Pediatric Nephrology, Faculty of Medicine, Federal University of Minas Gerais (UFMG), Belo Horizonte 30130-100, BrazilInterdisciplinary Laboratory of Medical Investigation, Unit of Pediatric Nephrology, Faculty of Medicine, Federal University of Minas Gerais (UFMG), Belo Horizonte 30130-100, BrazilInterdisciplinary Laboratory of Medical Investigation, Unit of Pediatric Nephrology, Faculty of Medicine, Federal University of Minas Gerais (UFMG), Belo Horizonte 30130-100, BrazilNephrotic syndrome (NS) is a complex clinical entity characterized by proteinuria, hypoalbuminemia, and edema. In this review, we propose the view of NS as a podocytopathy, highlighting the importance of understanding the role of podocytes in the development of this condition. We discuss the various etiologies of NS, ranging from congenital to primary renal diseases, as well as secondary forms due to systemic diseases. We also delve into the mechanisms underlying podocyte injury, which plays a crucial role in the development of NS. By viewing NS as a podocytopathy, we suggest potential implications for the diagnosis and treatment of this condition, including the use of podocyte-specific biomarkers and targeted therapies. Our review provides a comprehensive overview of NS and its underlying mechanisms, emphasizing the importance of a multidisciplinary approach to the diagnosis and management of this condition. Further research is essential to better understand the complex interplay between podocyte injury and the development of NS, with the ultimate goal of improving patient outcomes.https://www.mdpi.com/2673-8236/3/4/30nephrotic syndromepodocyteproteinuriaglomerular filtration barrierbiomarkers |
| spellingShingle | Pedro Alves Soares Vaz de Castro Thomas Fujihara Ide Fernando Crespo Torres Ana Cristina Simões e Silva The View of Pediatric Nephrotic Syndrome as a Podocytopathy Kidney and Dialysis nephrotic syndrome podocyte proteinuria glomerular filtration barrier biomarkers |
| title | The View of Pediatric Nephrotic Syndrome as a Podocytopathy |
| title_full | The View of Pediatric Nephrotic Syndrome as a Podocytopathy |
| title_fullStr | The View of Pediatric Nephrotic Syndrome as a Podocytopathy |
| title_full_unstemmed | The View of Pediatric Nephrotic Syndrome as a Podocytopathy |
| title_short | The View of Pediatric Nephrotic Syndrome as a Podocytopathy |
| title_sort | view of pediatric nephrotic syndrome as a podocytopathy |
| topic | nephrotic syndrome podocyte proteinuria glomerular filtration barrier biomarkers |
| url | https://www.mdpi.com/2673-8236/3/4/30 |
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