VBM with viscous fluid registration of grey matter segments in SPM.
Improved registration of grey matter segments in SPM has been achieved with the DARTEL algorithm. Previous work from our group suggested, however, that such improvements may not translate to studies of clinical groups. To address the registration issue in atrophic brains, this paper relaxed the cond...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2013-07-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnagi.2013.00030/full |
| _version_ | 1818317980829745152 |
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| author | João M. S. Pereira João M. S. Pereira Julio eAcosta-Cabronero Julio eAcosta-Cabronero George ePengas Li eXiong Peter J. Nestor Guy B. Williams |
| author_facet | João M. S. Pereira João M. S. Pereira Julio eAcosta-Cabronero Julio eAcosta-Cabronero George ePengas Li eXiong Peter J. Nestor Guy B. Williams |
| author_sort | João M. S. Pereira |
| collection | DOAJ |
| description | Improved registration of grey matter segments in SPM has been achieved with the DARTEL algorithm. Previous work from our group suggested, however, that such improvements may not translate to studies of clinical groups. To address the registration issue in atrophic brains, this paper relaxed the condition of diffeomorphism, central to DARTEL, and made use of a viscous fluid registration model with limited regularisation constraints to register the modulated grey matter probability maps to an intra-population template. Quantitative analysis of the registration results after the additional viscous fluid step showed no worsening of co-localisation of fiducials compared to DARTEL or unified segmentation methods, and the resulting voxel based morphometry (VBM) analyses were able to better identify atrophic regions and to produce results with fewer apparent false positives. DARTEL showed great sensitivity to atrophy, but the resulting VBM maps presented broad, amorphous regions of significance that are hard to interpret. We propose that the condition of diffeomorphism is not necessary for basic VBM studies in atrophic populations, but also that it has disadvantages that must be taken into consideration before a study. The presented viscous fluid registration method is proposed for VBM studies to enhance sensitivity and localizing power. |
| first_indexed | 2024-12-13T09:45:57Z |
| format | Article |
| id | doaj.art-04d21d7371c5472f8262fc2ca2a83915 |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-12-13T09:45:57Z |
| publishDate | 2013-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-04d21d7371c5472f8262fc2ca2a839152022-12-21T23:52:04ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652013-07-01510.3389/fnagi.2013.0003052497VBM with viscous fluid registration of grey matter segments in SPM.João M. S. Pereira0João M. S. Pereira1Julio eAcosta-Cabronero2Julio eAcosta-Cabronero3George ePengas4Li eXiong5Peter J. Nestor6Guy B. Williams7IBILI - Faculty of Medicine, University of CoimbraUniversity of CambridgeUniversity of CambridgeGerman Center for Neurodegenerative Diseases (DZNE)University of CambridgeZhongnan Hospital of Wuhan UniversityGerman Center for Neurodegenerative Diseases (DZNE)University of CambridgeImproved registration of grey matter segments in SPM has been achieved with the DARTEL algorithm. Previous work from our group suggested, however, that such improvements may not translate to studies of clinical groups. To address the registration issue in atrophic brains, this paper relaxed the condition of diffeomorphism, central to DARTEL, and made use of a viscous fluid registration model with limited regularisation constraints to register the modulated grey matter probability maps to an intra-population template. Quantitative analysis of the registration results after the additional viscous fluid step showed no worsening of co-localisation of fiducials compared to DARTEL or unified segmentation methods, and the resulting voxel based morphometry (VBM) analyses were able to better identify atrophic regions and to produce results with fewer apparent false positives. DARTEL showed great sensitivity to atrophy, but the resulting VBM maps presented broad, amorphous regions of significance that are hard to interpret. We propose that the condition of diffeomorphism is not necessary for basic VBM studies in atrophic populations, but also that it has disadvantages that must be taken into consideration before a study. The presented viscous fluid registration method is proposed for VBM studies to enhance sensitivity and localizing power.http://journal.frontiersin.org/Journal/10.3389/fnagi.2013.00030/fullDementiaMRIVBMRegistrationSPMDARTEL |
| spellingShingle | João M. S. Pereira João M. S. Pereira Julio eAcosta-Cabronero Julio eAcosta-Cabronero George ePengas Li eXiong Peter J. Nestor Guy B. Williams VBM with viscous fluid registration of grey matter segments in SPM. Frontiers in Aging Neuroscience Dementia MRI VBM Registration SPM DARTEL |
| title | VBM with viscous fluid registration of grey matter segments in SPM. |
| title_full | VBM with viscous fluid registration of grey matter segments in SPM. |
| title_fullStr | VBM with viscous fluid registration of grey matter segments in SPM. |
| title_full_unstemmed | VBM with viscous fluid registration of grey matter segments in SPM. |
| title_short | VBM with viscous fluid registration of grey matter segments in SPM. |
| title_sort | vbm with viscous fluid registration of grey matter segments in spm |
| topic | Dementia MRI VBM Registration SPM DARTEL |
| url | http://journal.frontiersin.org/Journal/10.3389/fnagi.2013.00030/full |
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