Effect of the BH3 Mimetic Polyphenol (–)-Gossypol (AT-101) on the in vitro and in vivo Growth of Malignant Mesothelioma

Effect of the BH3 Mimetic Polyphenol (–)-Gossypol (AT-101) on the in vitro and in vivo Growth of Malignant Mesothelioma

Malignant mesothelioma (MM) is a primary tumor arising from mesothelial cells. The survival of MM patients following traditional chemotherapy is poor, thus innovative treatments for MM are needed. (-)-gossypol (AT-101) is a BH3 mimetic compound which possesses anti-tumoral activity by targeting mult...

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Bibliographic Details
Main Authors: Monica Benvenuto, Rosanna Mattera, Joshua Ismaele Sticca, Piero Rossi, Chiara Cipriani, Maria Gabriella Giganti, Antonio Volpi, Andrea Modesti, Laura Masuelli, Roberto Bei
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Pharmacology
Subjects:
polyphenol
AT-101
BH3 mimetic
malignant mesothelioma
apoptosis
autophagy
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.01269/full

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