Drug Repurposing Approaches towards Defeating Multidrug-Resistant Gram-Negative Pathogens: Novel Polymyxin/Non-Antibiotic Combinations
Multidrug-resistant (MDR) Gram-negative pathogens remain an unmet public health threat. In recent times, increased rates of resistance have been reported not only to commonly used antibiotics, but also to the last-resort antibiotics, such as polymyxins. More worryingly, despite the current trends in...
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| Materiálatiipa: | Artihkal |
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MDPI AG
2022-11-01
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| Ráidu: | Pathogens |
| Fáttát: | |
| Liŋkkat: | https://www.mdpi.com/2076-0817/11/12/1420 |
| _version_ | 1827637358956118016 |
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| author | Augustine Koh Jing Jie Maytham Hussein Gauri G. Rao Jian Li Tony Velkov |
| author_facet | Augustine Koh Jing Jie Maytham Hussein Gauri G. Rao Jian Li Tony Velkov |
| author_sort | Augustine Koh Jing Jie |
| collection | DOAJ |
| description | Multidrug-resistant (MDR) Gram-negative pathogens remain an unmet public health threat. In recent times, increased rates of resistance have been reported not only to commonly used antibiotics, but also to the last-resort antibiotics, such as polymyxins. More worryingly, despite the current trends in resistance, there is a lack of new antibiotics in the drug-discovery pipeline. Hence, it is imperative that new strategies are developed to preserve the clinical efficacy of the current antibiotics, particularly the last-line agents. Combining conventional antibiotics such as polymyxins with non-antibiotics (or adjuvants), has emerged as a novel and effective strategy against otherwise untreatable MDR pathogens. This review explores the available literature detailing the latest polymyxin/non-antibiotic combinations, their mechanisms of action, and potential avenues to advance their clinical application. |
| first_indexed | 2024-03-09T15:58:58Z |
| format | Article |
| id | doaj.art-04d7663a25f14337b6fb8e1d6c5c909f |
| institution | Directory Open Access Journal |
| issn | 2076-0817 |
| language | English |
| last_indexed | 2024-03-09T15:58:58Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathogens |
| spelling | doaj.art-04d7663a25f14337b6fb8e1d6c5c909f2023-11-24T17:12:23ZengMDPI AGPathogens2076-08172022-11-011112142010.3390/pathogens11121420Drug Repurposing Approaches towards Defeating Multidrug-Resistant Gram-Negative Pathogens: Novel Polymyxin/Non-Antibiotic CombinationsAugustine Koh Jing Jie0Maytham Hussein1Gauri G. Rao2Jian Li3Tony Velkov4Department of Biochemistry and Pharmacology, School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Parkville, VIC 3010, AustraliaMonash Biomedicine Discovery Institute, Department of Microbiology, Monash University, Clayton, VIC 3800, AustraliaDivision of Pharmacotherapy and Experimental Therapeutics, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, USAMonash Biomedicine Discovery Institute, Department of Microbiology, Monash University, Clayton, VIC 3800, AustraliaMonash Biomedicine Discovery Institute, Department of Microbiology, Monash University, Clayton, VIC 3800, AustraliaMultidrug-resistant (MDR) Gram-negative pathogens remain an unmet public health threat. In recent times, increased rates of resistance have been reported not only to commonly used antibiotics, but also to the last-resort antibiotics, such as polymyxins. More worryingly, despite the current trends in resistance, there is a lack of new antibiotics in the drug-discovery pipeline. Hence, it is imperative that new strategies are developed to preserve the clinical efficacy of the current antibiotics, particularly the last-line agents. Combining conventional antibiotics such as polymyxins with non-antibiotics (or adjuvants), has emerged as a novel and effective strategy against otherwise untreatable MDR pathogens. This review explores the available literature detailing the latest polymyxin/non-antibiotic combinations, their mechanisms of action, and potential avenues to advance their clinical application.https://www.mdpi.com/2076-0817/11/12/1420antimicrobial resistancepolymyxinsdrug repurposingnon-antibiotic agents |
| spellingShingle | Augustine Koh Jing Jie Maytham Hussein Gauri G. Rao Jian Li Tony Velkov Drug Repurposing Approaches towards Defeating Multidrug-Resistant Gram-Negative Pathogens: Novel Polymyxin/Non-Antibiotic Combinations Pathogens antimicrobial resistance polymyxins drug repurposing non-antibiotic agents |
| title | Drug Repurposing Approaches towards Defeating Multidrug-Resistant Gram-Negative Pathogens: Novel Polymyxin/Non-Antibiotic Combinations |
| title_full | Drug Repurposing Approaches towards Defeating Multidrug-Resistant Gram-Negative Pathogens: Novel Polymyxin/Non-Antibiotic Combinations |
| title_fullStr | Drug Repurposing Approaches towards Defeating Multidrug-Resistant Gram-Negative Pathogens: Novel Polymyxin/Non-Antibiotic Combinations |
| title_full_unstemmed | Drug Repurposing Approaches towards Defeating Multidrug-Resistant Gram-Negative Pathogens: Novel Polymyxin/Non-Antibiotic Combinations |
| title_short | Drug Repurposing Approaches towards Defeating Multidrug-Resistant Gram-Negative Pathogens: Novel Polymyxin/Non-Antibiotic Combinations |
| title_sort | drug repurposing approaches towards defeating multidrug resistant gram negative pathogens novel polymyxin non antibiotic combinations |
| topic | antimicrobial resistance polymyxins drug repurposing non-antibiotic agents |
| url | https://www.mdpi.com/2076-0817/11/12/1420 |
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