Triclocarban exposure exaggerates colitis and colon tumorigenesis: roles of gut microbiota involved
Triclocarban (TCC) is a widely used antimicrobial ingredient in consumer products and is a ubiquitous contaminant in the environment. In 2016, the FDA removed TCC from over-the-counter handwashing products, but this compound is still approved for use in many other personal care products. A better un...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2020-11-01
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| Series: | Gut Microbes |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/19490976.2019.1690364 |
| _version_ | 1818615086498971648 |
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| author | Haixia Yang Katherine Z. Sanidad Weicang Wang Minhao Xie Min Gu Xiaoqiong Cao Hang Xiao Guodong Zhang |
| author_facet | Haixia Yang Katherine Z. Sanidad Weicang Wang Minhao Xie Min Gu Xiaoqiong Cao Hang Xiao Guodong Zhang |
| author_sort | Haixia Yang |
| collection | DOAJ |
| description | Triclocarban (TCC) is a widely used antimicrobial ingredient in consumer products and is a ubiquitous contaminant in the environment. In 2016, the FDA removed TCC from over-the-counter handwashing products, but this compound is still approved for use in many other personal care products. A better understanding of its impact on human health could lead to significant impact for public health and regulatory policies. Here we show that exposure to low-dose TCC exaggerated the severity of colitis and exacerbated the development of colitis-associated colon tumorigenesis, via gut microbiota-dependent mechanisms. Exposure to TCC increased dextran sodium sulfate (DSS)- and interleukin 10 (IL-10) knockout-induced colitis, and exaggerated azoxymethane (AOM)/DSS-induced colon tumorigenesis in mice. Regarding the mechanisms, TCC exposure reduced the diversity and altered the composition of gut microbiota and failed to promote DSS-induced colitis in mice lacking the microbiota, supporting that the presence of the microbiota is critical for the pro-colitis effects of TCC. Together, these results support TCC could be a novel risk factor for colitis and colitis-associated colon cancer, and further regulatory policies on this compound could be needed. |
| first_indexed | 2024-12-16T16:28:19Z |
| format | Article |
| id | doaj.art-04d80385c681408583befe5ff02a9599 |
| institution | Directory Open Access Journal |
| issn | 1949-0976 1949-0984 |
| language | English |
| last_indexed | 2024-12-16T16:28:19Z |
| publishDate | 2020-11-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Gut Microbes |
| spelling | doaj.art-04d80385c681408583befe5ff02a95992022-12-21T22:24:40ZengTaylor & Francis GroupGut Microbes1949-09761949-09842020-11-0112110.1080/19490976.2019.16903641690364Triclocarban exposure exaggerates colitis and colon tumorigenesis: roles of gut microbiota involvedHaixia Yang0Katherine Z. Sanidad1Weicang Wang2Minhao Xie3Min Gu4Xiaoqiong Cao5Hang Xiao6Guodong Zhang7University of MassachusettsUniversity of MassachusettsUniversity of MassachusettsUniversity of MassachusettsUniversity of MassachusettsUniversity of MassachusettsUniversity of MassachusettsUniversity of MassachusettsTriclocarban (TCC) is a widely used antimicrobial ingredient in consumer products and is a ubiquitous contaminant in the environment. In 2016, the FDA removed TCC from over-the-counter handwashing products, but this compound is still approved for use in many other personal care products. A better understanding of its impact on human health could lead to significant impact for public health and regulatory policies. Here we show that exposure to low-dose TCC exaggerated the severity of colitis and exacerbated the development of colitis-associated colon tumorigenesis, via gut microbiota-dependent mechanisms. Exposure to TCC increased dextran sodium sulfate (DSS)- and interleukin 10 (IL-10) knockout-induced colitis, and exaggerated azoxymethane (AOM)/DSS-induced colon tumorigenesis in mice. Regarding the mechanisms, TCC exposure reduced the diversity and altered the composition of gut microbiota and failed to promote DSS-induced colitis in mice lacking the microbiota, supporting that the presence of the microbiota is critical for the pro-colitis effects of TCC. Together, these results support TCC could be a novel risk factor for colitis and colitis-associated colon cancer, and further regulatory policies on this compound could be needed.http://dx.doi.org/10.1080/19490976.2019.1690364gut microbiotainflammatory bowel diseasecolon cancerenvironmental chemicaltriclocarban |
| spellingShingle | Haixia Yang Katherine Z. Sanidad Weicang Wang Minhao Xie Min Gu Xiaoqiong Cao Hang Xiao Guodong Zhang Triclocarban exposure exaggerates colitis and colon tumorigenesis: roles of gut microbiota involved Gut Microbes gut microbiota inflammatory bowel disease colon cancer environmental chemical triclocarban |
| title | Triclocarban exposure exaggerates colitis and colon tumorigenesis: roles of gut microbiota involved |
| title_full | Triclocarban exposure exaggerates colitis and colon tumorigenesis: roles of gut microbiota involved |
| title_fullStr | Triclocarban exposure exaggerates colitis and colon tumorigenesis: roles of gut microbiota involved |
| title_full_unstemmed | Triclocarban exposure exaggerates colitis and colon tumorigenesis: roles of gut microbiota involved |
| title_short | Triclocarban exposure exaggerates colitis and colon tumorigenesis: roles of gut microbiota involved |
| title_sort | triclocarban exposure exaggerates colitis and colon tumorigenesis roles of gut microbiota involved |
| topic | gut microbiota inflammatory bowel disease colon cancer environmental chemical triclocarban |
| url | http://dx.doi.org/10.1080/19490976.2019.1690364 |
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