Could nutritional supplements act as therapeutic adjuvants in COVID-19?
Abstract Background The role of the immune system and inflammatory response in the pathogenesis of the severe manifestations of coronavirus disease 2019 (COVID-19) is well known. Currently, different therapies active on the immune system are used for the management of COVID-19. The involvement of th...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-02-01
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| Series: | Italian Journal of Pediatrics |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13052-021-00990-0 |
| _version_ | 1819283713491468288 |
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| author | Giorgio Costagliola Erika Spada Pasquale Comberiati Diego G. Peroni |
| author_facet | Giorgio Costagliola Erika Spada Pasquale Comberiati Diego G. Peroni |
| author_sort | Giorgio Costagliola |
| collection | DOAJ |
| description | Abstract Background The role of the immune system and inflammatory response in the pathogenesis of the severe manifestations of coronavirus disease 2019 (COVID-19) is well known. Currently, different therapies active on the immune system are used for the management of COVID-19. The involvement of the immune system also opens the opportunity for the use of nutritional supplements with antimicrobial and immunomodulatory activity. Main aspects Nutritional supplements with antimicrobial and immunomodulatory activity are promising therapeutic adjuvants for the treatment of COVID-19, and also for the prevention of viral spreading. In particular, the role of vitamin D, probiotics, lactoferrin, and zinc is of significant clinical interest, although there are only a few data on their use in COVID-19 patients. Their molecular actions, together with the results of studies performed on other respiratory infections, strongly suggest their potential utility in COVID-19. This article discusses the main properties of these nutritional supplements and their potential applicability in the prevention and treatment of COVID-19. Conclusion The supplementation with vitamin D, probiotics, lactoferrin and zinc could have a role both in preventing SARS-CoV-2 infection and in mitigating the clinical course in infected patients, contributing in the prevention of immune-mediated organ damage. |
| first_indexed | 2024-12-24T01:35:51Z |
| format | Article |
| id | doaj.art-04d83986bfa249498af90acb26af0e00 |
| institution | Directory Open Access Journal |
| issn | 1824-7288 |
| language | English |
| last_indexed | 2024-12-24T01:35:51Z |
| publishDate | 2021-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Italian Journal of Pediatrics |
| spelling | doaj.art-04d83986bfa249498af90acb26af0e002022-12-21T17:22:11ZengBMCItalian Journal of Pediatrics1824-72882021-02-014711510.1186/s13052-021-00990-0Could nutritional supplements act as therapeutic adjuvants in COVID-19?Giorgio Costagliola0Erika Spada1Pasquale Comberiati2Diego G. Peroni3Clinical and Experimental Medicine, Division of Pediatrics, University of PisaClinical and Experimental Medicine, Division of Pediatrics, University of PisaClinical and Experimental Medicine, Division of Pediatrics, University of PisaClinical and Experimental Medicine, Division of Pediatrics, University of PisaAbstract Background The role of the immune system and inflammatory response in the pathogenesis of the severe manifestations of coronavirus disease 2019 (COVID-19) is well known. Currently, different therapies active on the immune system are used for the management of COVID-19. The involvement of the immune system also opens the opportunity for the use of nutritional supplements with antimicrobial and immunomodulatory activity. Main aspects Nutritional supplements with antimicrobial and immunomodulatory activity are promising therapeutic adjuvants for the treatment of COVID-19, and also for the prevention of viral spreading. In particular, the role of vitamin D, probiotics, lactoferrin, and zinc is of significant clinical interest, although there are only a few data on their use in COVID-19 patients. Their molecular actions, together with the results of studies performed on other respiratory infections, strongly suggest their potential utility in COVID-19. This article discusses the main properties of these nutritional supplements and their potential applicability in the prevention and treatment of COVID-19. Conclusion The supplementation with vitamin D, probiotics, lactoferrin and zinc could have a role both in preventing SARS-CoV-2 infection and in mitigating the clinical course in infected patients, contributing in the prevention of immune-mediated organ damage.https://doi.org/10.1186/s13052-021-00990-0COVID-19Cytokine stormImmune systemLactoferrinNutritionProbiotics |
| spellingShingle | Giorgio Costagliola Erika Spada Pasquale Comberiati Diego G. Peroni Could nutritional supplements act as therapeutic adjuvants in COVID-19? Italian Journal of Pediatrics COVID-19 Cytokine storm Immune system Lactoferrin Nutrition Probiotics |
| title | Could nutritional supplements act as therapeutic adjuvants in COVID-19? |
| title_full | Could nutritional supplements act as therapeutic adjuvants in COVID-19? |
| title_fullStr | Could nutritional supplements act as therapeutic adjuvants in COVID-19? |
| title_full_unstemmed | Could nutritional supplements act as therapeutic adjuvants in COVID-19? |
| title_short | Could nutritional supplements act as therapeutic adjuvants in COVID-19? |
| title_sort | could nutritional supplements act as therapeutic adjuvants in covid 19 |
| topic | COVID-19 Cytokine storm Immune system Lactoferrin Nutrition Probiotics |
| url | https://doi.org/10.1186/s13052-021-00990-0 |
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