Stepwise activation mechanism of the scramblase nhTMEM16 revealed by cryo-EM

Stepwise activation mechanism of the scramblase nhTMEM16 revealed by cryo-EM

Scramblases catalyze the movement of lipids between both leaflets of a bilayer. Whereas the X-ray structure of the protein nhTMEM16 has previously revealed the architecture of a Ca2+-dependent lipid scramblase, its regulation mechanism has remained elusive. Here, we have used cryo-electron microscop...

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Bibliographic Details
Main Authors: Valeria Kalienkova, Vanessa Clerico Mosina, Laura Bryner, Gert T Oostergetel, Raimund Dutzler, Cristina Paulino
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-02-01
Series:eLife
Subjects:
cryo-EM
TMEM16
lipid scrambling
activation mechanism
membrane interaction
Online Access:https://elifesciences.org/articles/44364

Internet

https://elifesciences.org/articles/44364

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