Association of intraosseous and intravenous access with patient outcome in out-of-hospital cardiac arrest
Abstract Here we report the results of a study on the association between drug delivery via intravenous route or intraosseous route in out-of-hospital cardiac arrest. Intraosseous drug delivery is considered an alternative option in resuscitation if intravenous access is difficult or impossible. Int...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-11-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-48350-8 |
| _version_ | 1797415377448206336 |
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| author | Frederik Nancke Nilsson Søren Bie-Bogh Louise Milling Peter Martin Hansen Helena Pedersen Erika F. Christensen Jens Stubager Knudsen Helle Collatz Christensen Fredrik Folke David Høen-Beck Ulla Væggemose Anne Craveiro Brøchner Søren Mikkelsen |
| author_facet | Frederik Nancke Nilsson Søren Bie-Bogh Louise Milling Peter Martin Hansen Helena Pedersen Erika F. Christensen Jens Stubager Knudsen Helle Collatz Christensen Fredrik Folke David Høen-Beck Ulla Væggemose Anne Craveiro Brøchner Søren Mikkelsen |
| author_sort | Frederik Nancke Nilsson |
| collection | DOAJ |
| description | Abstract Here we report the results of a study on the association between drug delivery via intravenous route or intraosseous route in out-of-hospital cardiac arrest. Intraosseous drug delivery is considered an alternative option in resuscitation if intravenous access is difficult or impossible. Intraosseous uptake of drugs may, however, be compromised. We have performed a retrospective cohort study of all Danish patients with out-of-hospital cardiac arrest in the years 2016–2020 to investigate whether mortality is associated with the route of drug delivery. Outcome was 30-day mortality, death at the scene, no prehospital return of spontaneous circulation, and 7- and 90-days mortality. 17,250 patients had out-of-hospital cardiac arrest. 6243 patients received no treatment and were excluded. 1908 patients had sustained return of spontaneous circulation before access to the vascular bed was obtained. 2061 patients were unidentified, and 286 cases were erroneously registered. Thus, this report consist of results from 6752 patients. Drug delivery by intraosseous route is associated with increased OR of: No spontaneous circulation at any time (OR 1.51), Death at 7 days (OR 1.94), 30 days (2.02), and 90 days (OR 2.29). Intraosseous drug delivery in out-of-hospital cardiac arrest is associated with overall poorer outcomes than intravenous drug delivery. |
| first_indexed | 2024-03-09T05:47:46Z |
| format | Article |
| id | doaj.art-04dc8ffc7a3a4d08bb789979d26e39e6 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-09T05:47:46Z |
| publishDate | 2023-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-04dc8ffc7a3a4d08bb789979d26e39e62023-12-03T12:19:43ZengNature PortfolioScientific Reports2045-23222023-11-011311710.1038/s41598-023-48350-8Association of intraosseous and intravenous access with patient outcome in out-of-hospital cardiac arrestFrederik Nancke Nilsson0Søren Bie-Bogh1Louise Milling2Peter Martin Hansen3Helena Pedersen4Erika F. Christensen5Jens Stubager Knudsen6Helle Collatz Christensen7Fredrik Folke8David Høen-Beck9Ulla Væggemose10Anne Craveiro Brøchner11Søren Mikkelsen12The Prehospital Research Unit, Department of Regional Health Research, University of Southern DenmarkOPEN, Open Patient Data Explorative Network, University of Southern DenmarkThe Prehospital Research Unit, Department of Regional Health Research, University of Southern DenmarkThe Prehospital Research Unit, Department of Regional Health Research, University of Southern DenmarkThe Prehospital Research Unit, Department of Regional Health Research, University of Southern DenmarkDepartment of Clinical Medicine, Centre for Prehospital and Emergency Research, Aalborg University Hospital, Aalborg UniversityThe Danish Air AmbulancePrehospital Center, University of CopenhagenCopenhagen Emergency Medical Services, University of CopenhagenDepartment of Anaesthesiology, Denmark and Prehospital Center, Holbæk HospitalDepartment of Research and Development, Prehospital Emergency Medical Services, Central Denmark RegionThe Prehospital Research Unit, Department of Regional Health Research, University of Southern DenmarkThe Prehospital Research Unit, Department of Regional Health Research, University of Southern DenmarkAbstract Here we report the results of a study on the association between drug delivery via intravenous route or intraosseous route in out-of-hospital cardiac arrest. Intraosseous drug delivery is considered an alternative option in resuscitation if intravenous access is difficult or impossible. Intraosseous uptake of drugs may, however, be compromised. We have performed a retrospective cohort study of all Danish patients with out-of-hospital cardiac arrest in the years 2016–2020 to investigate whether mortality is associated with the route of drug delivery. Outcome was 30-day mortality, death at the scene, no prehospital return of spontaneous circulation, and 7- and 90-days mortality. 17,250 patients had out-of-hospital cardiac arrest. 6243 patients received no treatment and were excluded. 1908 patients had sustained return of spontaneous circulation before access to the vascular bed was obtained. 2061 patients were unidentified, and 286 cases were erroneously registered. Thus, this report consist of results from 6752 patients. Drug delivery by intraosseous route is associated with increased OR of: No spontaneous circulation at any time (OR 1.51), Death at 7 days (OR 1.94), 30 days (2.02), and 90 days (OR 2.29). Intraosseous drug delivery in out-of-hospital cardiac arrest is associated with overall poorer outcomes than intravenous drug delivery.https://doi.org/10.1038/s41598-023-48350-8 |
| spellingShingle | Frederik Nancke Nilsson Søren Bie-Bogh Louise Milling Peter Martin Hansen Helena Pedersen Erika F. Christensen Jens Stubager Knudsen Helle Collatz Christensen Fredrik Folke David Høen-Beck Ulla Væggemose Anne Craveiro Brøchner Søren Mikkelsen Association of intraosseous and intravenous access with patient outcome in out-of-hospital cardiac arrest Scientific Reports |
| title | Association of intraosseous and intravenous access with patient outcome in out-of-hospital cardiac arrest |
| title_full | Association of intraosseous and intravenous access with patient outcome in out-of-hospital cardiac arrest |
| title_fullStr | Association of intraosseous and intravenous access with patient outcome in out-of-hospital cardiac arrest |
| title_full_unstemmed | Association of intraosseous and intravenous access with patient outcome in out-of-hospital cardiac arrest |
| title_short | Association of intraosseous and intravenous access with patient outcome in out-of-hospital cardiac arrest |
| title_sort | association of intraosseous and intravenous access with patient outcome in out of hospital cardiac arrest |
| url | https://doi.org/10.1038/s41598-023-48350-8 |
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