Hepatic pleomorphic leiomyosarcoma after surgery for gastric gastrointestinal stromal tumor: a case report
Abstract Background Pleomorphic leiomyosarcomas (PLMSs) are extremely rare tumors. We present the first case of hepatic primary PLMS after surgery for gastric gastrointestinal stromal tumor (GIST). Case presentation The patient was a 62-year-old man who was referred to our hospital for resection of...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2019-04-01
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| Series: | Surgical Case Reports |
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| Online Access: | http://link.springer.com/article/10.1186/s40792-019-0622-9 |
| _version_ | 1818293709904543744 |
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| author | Ryo Muranushi Kouki Hoshino Kei Hagiwara Takahiro Yamanaka Norihiro Ishii Mariko Tsukagoshi Takamichi Igarashi Hiroshi Tanaka Akira Watanabe Norio Kubo Kenichiro Araki Norifumi Harimoto Hayato Ikota Kei Shibuya Masaya Miyazaki Ken Shirabe |
| author_facet | Ryo Muranushi Kouki Hoshino Kei Hagiwara Takahiro Yamanaka Norihiro Ishii Mariko Tsukagoshi Takamichi Igarashi Hiroshi Tanaka Akira Watanabe Norio Kubo Kenichiro Araki Norifumi Harimoto Hayato Ikota Kei Shibuya Masaya Miyazaki Ken Shirabe |
| author_sort | Ryo Muranushi |
| collection | DOAJ |
| description | Abstract Background Pleomorphic leiomyosarcomas (PLMSs) are extremely rare tumors. We present the first case of hepatic primary PLMS after surgery for gastric gastrointestinal stromal tumor (GIST). Case presentation The patient was a 62-year-old man who was referred to our hospital for resection of a hepatic tumor arising after gastric GIST surgery that was resistant to imatinib and sunitinib. A 40-mm tumor in the left lobe of the liver and three small nodules in the right lobe were detected. We performed hepatic left lobectomy and partial resections for three lesions. According to the histopathological and immunohistochemical findings and c-kit gene mutations analysis, the main tumor was diagnosed as a PLMS. Conclusion It is necessary to consider the possibility that imatinib-resistant GIST recurrence lesions are a different kind of soft-tissue sarcoma. Accurate diagnosis is required to not miss the opportunity for radical excision of PLMS. |
| first_indexed | 2024-12-13T03:20:10Z |
| format | Article |
| id | doaj.art-04dca05d7f2a4fadb63117f6ddaa7074 |
| institution | Directory Open Access Journal |
| issn | 2198-7793 |
| language | English |
| last_indexed | 2024-12-13T03:20:10Z |
| publishDate | 2019-04-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Surgical Case Reports |
| spelling | doaj.art-04dca05d7f2a4fadb63117f6ddaa70742022-12-22T00:01:22ZengSpringerOpenSurgical Case Reports2198-77932019-04-01511610.1186/s40792-019-0622-9Hepatic pleomorphic leiomyosarcoma after surgery for gastric gastrointestinal stromal tumor: a case reportRyo Muranushi0Kouki Hoshino1Kei Hagiwara2Takahiro Yamanaka3Norihiro Ishii4Mariko Tsukagoshi5Takamichi Igarashi6Hiroshi Tanaka7Akira Watanabe8Norio Kubo9Kenichiro Araki10Norifumi Harimoto11Hayato Ikota12Kei Shibuya13Masaya Miyazaki14Ken Shirabe15Department of General Surgical Science, Division of Hepatobiliary and Pancreatic Surgery, Graduate School of Medicine, Gunma UniversityDepartment of General Surgical Science, Division of Hepatobiliary and Pancreatic Surgery, Graduate School of Medicine, Gunma UniversityDepartment of General Surgical Science, Division of Hepatobiliary and Pancreatic Surgery, Graduate School of Medicine, Gunma UniversityDepartment of General Surgical Science, Division of Hepatobiliary and Pancreatic Surgery, Graduate School of Medicine, Gunma UniversityDepartment of General Surgical Science, Division of Hepatobiliary and Pancreatic Surgery, Graduate School of Medicine, Gunma UniversityDepartment of General Surgical Science, Division of Hepatobiliary and Pancreatic Surgery, Graduate School of Medicine, Gunma UniversityDepartment of General Surgical Science, Division of Hepatobiliary and Pancreatic Surgery, Graduate School of Medicine, Gunma UniversityDepartment of General Surgical Science, Division of Hepatobiliary and Pancreatic Surgery, Graduate School of Medicine, Gunma UniversityDepartment of General Surgical Science, Division of Hepatobiliary and Pancreatic Surgery, Graduate School of Medicine, Gunma UniversityDepartment of General Surgical Science, Division of Hepatobiliary and Pancreatic Surgery, Graduate School of Medicine, Gunma UniversityDepartment of General Surgical Science, Division of Hepatobiliary and Pancreatic Surgery, Graduate School of Medicine, Gunma UniversityDepartment of General Surgical Science, Division of Hepatobiliary and Pancreatic Surgery, Graduate School of Medicine, Gunma UniversityDepartment of Human Pathology, Graduate School of Medicine, Gunma UniversityDepartment of Diagnostic and interventional Radiology, Gunma University HospitalDepartment of Diagnostic and interventional Radiology, Gunma University HospitalDepartment of General Surgical Science, Division of Hepatobiliary and Pancreatic Surgery, Graduate School of Medicine, Gunma UniversityAbstract Background Pleomorphic leiomyosarcomas (PLMSs) are extremely rare tumors. We present the first case of hepatic primary PLMS after surgery for gastric gastrointestinal stromal tumor (GIST). Case presentation The patient was a 62-year-old man who was referred to our hospital for resection of a hepatic tumor arising after gastric GIST surgery that was resistant to imatinib and sunitinib. A 40-mm tumor in the left lobe of the liver and three small nodules in the right lobe were detected. We performed hepatic left lobectomy and partial resections for three lesions. According to the histopathological and immunohistochemical findings and c-kit gene mutations analysis, the main tumor was diagnosed as a PLMS. Conclusion It is necessary to consider the possibility that imatinib-resistant GIST recurrence lesions are a different kind of soft-tissue sarcoma. Accurate diagnosis is required to not miss the opportunity for radical excision of PLMS.http://link.springer.com/article/10.1186/s40792-019-0622-9Pleomorphic hepatic leiomyosarcomaHepatectomyGastrointestinal stromal tumor |
| spellingShingle | Ryo Muranushi Kouki Hoshino Kei Hagiwara Takahiro Yamanaka Norihiro Ishii Mariko Tsukagoshi Takamichi Igarashi Hiroshi Tanaka Akira Watanabe Norio Kubo Kenichiro Araki Norifumi Harimoto Hayato Ikota Kei Shibuya Masaya Miyazaki Ken Shirabe Hepatic pleomorphic leiomyosarcoma after surgery for gastric gastrointestinal stromal tumor: a case report Surgical Case Reports Pleomorphic hepatic leiomyosarcoma Hepatectomy Gastrointestinal stromal tumor |
| title | Hepatic pleomorphic leiomyosarcoma after surgery for gastric gastrointestinal stromal tumor: a case report |
| title_full | Hepatic pleomorphic leiomyosarcoma after surgery for gastric gastrointestinal stromal tumor: a case report |
| title_fullStr | Hepatic pleomorphic leiomyosarcoma after surgery for gastric gastrointestinal stromal tumor: a case report |
| title_full_unstemmed | Hepatic pleomorphic leiomyosarcoma after surgery for gastric gastrointestinal stromal tumor: a case report |
| title_short | Hepatic pleomorphic leiomyosarcoma after surgery for gastric gastrointestinal stromal tumor: a case report |
| title_sort | hepatic pleomorphic leiomyosarcoma after surgery for gastric gastrointestinal stromal tumor a case report |
| topic | Pleomorphic hepatic leiomyosarcoma Hepatectomy Gastrointestinal stromal tumor |
| url | http://link.springer.com/article/10.1186/s40792-019-0622-9 |
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