Activin A targets extrasynaptic NMDA receptors to ameliorate neuronal and behavioral deficits in a mouse model of Huntington disease

Activin A targets extrasynaptic NMDA receptors to ameliorate neuronal and behavioral deficits in a mouse model of Huntington disease

Cortical-striatal synaptic dysfunction, including enhanced toxic signaling by extrasynaptic N-methyl-d-aspartate receptors (eNMDARs), precedes neurodegeneration in Huntington disease (HD). A previous study showed Activin A, whose transcription is upregulated by calcium influx via synaptic NMDARs, su...

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Bibliographic Details
Main Authors: Wissam B. Nassrallah, Daniel Ramandi, Judy Cheng, Jean Oh, James Mackay, Marja D. Sepers, David Lau, Hilmar Bading, Lynn A. Raymond
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Neurobiology of Disease
Subjects:
Striatal medium-sized spiny neuron
Synapse
Patch clamp recording
Glutamatergic neurotransmission
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996123003765

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