Ferroptosis-related metabolic mechanism and nanoparticulate anticancer drug delivery systems based on ferroptosis
Ferroptosis is a new type of cell death discovered in recent years that distinguishes from apoptosis and necrosis, mainly caused by the imbalance between the production and degradation of lipid reactive oxygen species in cells. Although the mechanism of ferroptosis is not yet clear, the phenomenon o...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-04-01
|
| Series: | Saudi Pharmaceutical Journal |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1319016423000385 |
| _version_ | 1797854307914088448 |
|---|---|
| author | Danni Yan Zhenghong Wu Xiaole Qi |
| author_facet | Danni Yan Zhenghong Wu Xiaole Qi |
| author_sort | Danni Yan |
| collection | DOAJ |
| description | Ferroptosis is a new type of cell death discovered in recent years that distinguishes from apoptosis and necrosis, mainly caused by the imbalance between the production and degradation of lipid reactive oxygen species in cells. Although the mechanism of ferroptosis is not yet clear, the phenomenon of ferroptosis has attracted widespread attention from researchers and has become a new hotspot in anti-tumor research. Studies have shown that ferroptosis is involved in the occurrence and development of a variety of diseases such as nervous system diseases, cardiovascular diseases and cancer. And inhibiting or inducing the occurrence of ferroptosis can effectively intervene in related diseases. At the same time, nanotechnology, by virtue of its distinct advantages, has been widely used in the development of nanodrug delivery systems. This review outlines current the advance on the intersection of ferroptosis and biomedical nanotechnology. In this review, the discovery and characteristics of ferroptosis, the mechanism of occurrence and the relationship with disease are summarized. More importantly, we summarized the strategies for inducing ferroptosis based on nanoparticulate drug delivery systems for cancer treatment. |
| first_indexed | 2024-04-09T20:03:50Z |
| format | Article |
| id | doaj.art-04de53cc77c546c8bcdae4ac78560830 |
| institution | Directory Open Access Journal |
| issn | 1319-0164 |
| language | English |
| last_indexed | 2024-04-09T20:03:50Z |
| publishDate | 2023-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Saudi Pharmaceutical Journal |
| spelling | doaj.art-04de53cc77c546c8bcdae4ac785608302023-04-02T06:12:15ZengElsevierSaudi Pharmaceutical Journal1319-01642023-04-01314554568Ferroptosis-related metabolic mechanism and nanoparticulate anticancer drug delivery systems based on ferroptosisDanni Yan0Zhenghong Wu1Xiaole Qi2Key Laboratory of Modern Chinese Medicines, China Pharmaceutical University, Nanjing 210009, ChinaKey Laboratory of Modern Chinese Medicines, China Pharmaceutical University, Nanjing 210009, China; Corresponding authors at: Key Laboratory of Modern Chinese Medicines, China Pharmaceutical University, Nanjing 210009, China.Key Laboratory of Modern Chinese Medicines, China Pharmaceutical University, Nanjing 210009, China; Industrial Technology Innovation Platform, Zhejiang Center for Safety Study of Drug Substances, Hangzhou 310018, China; Corresponding authors at: Key Laboratory of Modern Chinese Medicines, China Pharmaceutical University, Nanjing 210009, China.Ferroptosis is a new type of cell death discovered in recent years that distinguishes from apoptosis and necrosis, mainly caused by the imbalance between the production and degradation of lipid reactive oxygen species in cells. Although the mechanism of ferroptosis is not yet clear, the phenomenon of ferroptosis has attracted widespread attention from researchers and has become a new hotspot in anti-tumor research. Studies have shown that ferroptosis is involved in the occurrence and development of a variety of diseases such as nervous system diseases, cardiovascular diseases and cancer. And inhibiting or inducing the occurrence of ferroptosis can effectively intervene in related diseases. At the same time, nanotechnology, by virtue of its distinct advantages, has been widely used in the development of nanodrug delivery systems. This review outlines current the advance on the intersection of ferroptosis and biomedical nanotechnology. In this review, the discovery and characteristics of ferroptosis, the mechanism of occurrence and the relationship with disease are summarized. More importantly, we summarized the strategies for inducing ferroptosis based on nanoparticulate drug delivery systems for cancer treatment.http://www.sciencedirect.com/science/article/pii/S1319016423000385FerroptosisMechanismDiseasesNanotherapeuticsCancer treatment |
| spellingShingle | Danni Yan Zhenghong Wu Xiaole Qi Ferroptosis-related metabolic mechanism and nanoparticulate anticancer drug delivery systems based on ferroptosis Saudi Pharmaceutical Journal Ferroptosis Mechanism Diseases Nanotherapeutics Cancer treatment |
| title | Ferroptosis-related metabolic mechanism and nanoparticulate anticancer drug delivery systems based on ferroptosis |
| title_full | Ferroptosis-related metabolic mechanism and nanoparticulate anticancer drug delivery systems based on ferroptosis |
| title_fullStr | Ferroptosis-related metabolic mechanism and nanoparticulate anticancer drug delivery systems based on ferroptosis |
| title_full_unstemmed | Ferroptosis-related metabolic mechanism and nanoparticulate anticancer drug delivery systems based on ferroptosis |
| title_short | Ferroptosis-related metabolic mechanism and nanoparticulate anticancer drug delivery systems based on ferroptosis |
| title_sort | ferroptosis related metabolic mechanism and nanoparticulate anticancer drug delivery systems based on ferroptosis |
| topic | Ferroptosis Mechanism Diseases Nanotherapeutics Cancer treatment |
| url | http://www.sciencedirect.com/science/article/pii/S1319016423000385 |
| work_keys_str_mv | AT danniyan ferroptosisrelatedmetabolicmechanismandnanoparticulateanticancerdrugdeliverysystemsbasedonferroptosis AT zhenghongwu ferroptosisrelatedmetabolicmechanismandnanoparticulateanticancerdrugdeliverysystemsbasedonferroptosis AT xiaoleqi ferroptosisrelatedmetabolicmechanismandnanoparticulateanticancerdrugdeliverysystemsbasedonferroptosis |