Hepatitis C and hepatitis B virus infection in different hemodialysis units in Belo Horizonte, Minas Gerais, Brazil
The prevalence, virological and epidemilogical aspects of the hepatitis C virus (HCV) and the hepatitis B virus (HBV) infections vary among hemodialysis patients in different countries. Aiming at analyzing these aspects of HCV and HBV infections in hemodialysis patients in Belo Horizonte, MG, Brazil...
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| Format: | Article |
| Language: | English |
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Fundação Oswaldo Cruz (FIOCRUZ)
2002-01-01
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| Series: | Memorias do Instituto Oswaldo Cruz |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762002000600003 |
| _version_ | 1797713462862807040 |
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| author | Busek Solange U Babá Élio H Tavares Filho Hélcio A Pimenta Lermíno Salomão Abraão Corrêa-Oliveira Rodrigo Oliveira Guilherme C |
| author_facet | Busek Solange U Babá Élio H Tavares Filho Hélcio A Pimenta Lermíno Salomão Abraão Corrêa-Oliveira Rodrigo Oliveira Guilherme C |
| author_sort | Busek Solange U |
| collection | DOAJ |
| description | The prevalence, virological and epidemilogical aspects of the hepatitis C virus (HCV) and the hepatitis B virus (HBV) infections vary among hemodialysis patients in different countries. Aiming at analyzing these aspects of HCV and HBV infections in hemodialysis patients in Belo Horizonte, MG, Brazil, we studied three hemodialysis units including 434 patients. Serology was used to detect anti-HCV and HBsAg. Reverse trancriptase nested polymerase chain reaction (RT-nested-PCR) of the 5'-noncoding region was used to detect circulating HCV RNA and restriction fragment length polymorphism analysis for genotyping. Seroprevalence varied from 26.5% to 11.1% for hepatitis C and from 5.9% to 0% for hepatitis B. Risk factors observed for HBV and/or HCV infections were the number of patients per dialysis unit, duration of treatment, number of clinics attended, number of blood units transfused, and lower level scholarity. Alanine aminotransferase levels were altered with a higher frequency in HBV or HCV seropositive patients. Half of ten patients, negative for anti-HCV, had detectable viremia by RT-nested-PCR, indicating that this technique should be used to confirm infections in this group of patients. The HCV genotype 1 was the most frequently observed, followed by the genotype 2, but no correlation was detected between genotype and clinical or epidemiological data. |
| first_indexed | 2024-03-12T07:36:59Z |
| format | Article |
| id | doaj.art-04e15aa2a4f74006841cf6ad20f0bf27 |
| institution | Directory Open Access Journal |
| issn | 0074-0276 1678-8060 |
| language | English |
| last_indexed | 2024-03-12T07:36:59Z |
| publishDate | 2002-01-01 |
| publisher | Fundação Oswaldo Cruz (FIOCRUZ) |
| record_format | Article |
| series | Memorias do Instituto Oswaldo Cruz |
| spelling | doaj.art-04e15aa2a4f74006841cf6ad20f0bf272023-09-02T21:28:47ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz0074-02761678-80602002-01-01976775778Hepatitis C and hepatitis B virus infection in different hemodialysis units in Belo Horizonte, Minas Gerais, BrazilBusek Solange UBabá Élio HTavares Filho Hélcio APimenta LermínoSalomão AbraãoCorrêa-Oliveira RodrigoOliveira Guilherme CThe prevalence, virological and epidemilogical aspects of the hepatitis C virus (HCV) and the hepatitis B virus (HBV) infections vary among hemodialysis patients in different countries. Aiming at analyzing these aspects of HCV and HBV infections in hemodialysis patients in Belo Horizonte, MG, Brazil, we studied three hemodialysis units including 434 patients. Serology was used to detect anti-HCV and HBsAg. Reverse trancriptase nested polymerase chain reaction (RT-nested-PCR) of the 5'-noncoding region was used to detect circulating HCV RNA and restriction fragment length polymorphism analysis for genotyping. Seroprevalence varied from 26.5% to 11.1% for hepatitis C and from 5.9% to 0% for hepatitis B. Risk factors observed for HBV and/or HCV infections were the number of patients per dialysis unit, duration of treatment, number of clinics attended, number of blood units transfused, and lower level scholarity. Alanine aminotransferase levels were altered with a higher frequency in HBV or HCV seropositive patients. Half of ten patients, negative for anti-HCV, had detectable viremia by RT-nested-PCR, indicating that this technique should be used to confirm infections in this group of patients. The HCV genotype 1 was the most frequently observed, followed by the genotype 2, but no correlation was detected between genotype and clinical or epidemiological data.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762002000600003alanine aminotransferasehepatitis C virus genotypehemodialysishepatitis Bhepatitis CprevalenceBelo HorizonteBrazil |
| spellingShingle | Busek Solange U Babá Élio H Tavares Filho Hélcio A Pimenta Lermíno Salomão Abraão Corrêa-Oliveira Rodrigo Oliveira Guilherme C Hepatitis C and hepatitis B virus infection in different hemodialysis units in Belo Horizonte, Minas Gerais, Brazil Memorias do Instituto Oswaldo Cruz alanine aminotransferase hepatitis C virus genotype hemodialysis hepatitis B hepatitis C prevalence Belo Horizonte Brazil |
| title | Hepatitis C and hepatitis B virus infection in different hemodialysis units in Belo Horizonte, Minas Gerais, Brazil |
| title_full | Hepatitis C and hepatitis B virus infection in different hemodialysis units in Belo Horizonte, Minas Gerais, Brazil |
| title_fullStr | Hepatitis C and hepatitis B virus infection in different hemodialysis units in Belo Horizonte, Minas Gerais, Brazil |
| title_full_unstemmed | Hepatitis C and hepatitis B virus infection in different hemodialysis units in Belo Horizonte, Minas Gerais, Brazil |
| title_short | Hepatitis C and hepatitis B virus infection in different hemodialysis units in Belo Horizonte, Minas Gerais, Brazil |
| title_sort | hepatitis c and hepatitis b virus infection in different hemodialysis units in belo horizonte minas gerais brazil |
| topic | alanine aminotransferase hepatitis C virus genotype hemodialysis hepatitis B hepatitis C prevalence Belo Horizonte Brazil |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762002000600003 |
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