Activation of arcuate nucleus GABA neurons promotes luteinizing hormone secretion and reproductive dysfunction: Implications for polycystic ovary syndromeResearch in context

Activation of arcuate nucleus GABA neurons promotes luteinizing hormone secretion and reproductive dysfunction: Implications for polycystic ovary syndromeResearch in context

Background: Enhanced GABA activity in the brain and a hyperactive hypothalamic-pituitary-gonadal axis are associated with polycystic ovary syndrome (PCOS), the most common form of anovulatory infertility. Women with PCOS exhibit elevated cerebrospinal fluid GABA levels and preclinical models of PCOS...

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Bibliographic Details
Main Authors: Mauro S.B. Silva, Elodie Desroziers, Sabine Hessler, Melanie Prescott, Chris Coyle, Allan E. Herbison, Rebecca E. Campbell
Format: Article
Language:English
Published: Elsevier 2019-06-01
Series:EBioMedicine
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396419303731

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