Interplay of dietary antioxidants and gut microbiome in human health: What has been learnt thus far?
The human gastrointestinal tract harbors a diverse range of microbial species, which helps to regulate various biological processes such as homeostasis of the gut barrier, stimulation of the immune system, and neurological health benefits from the gut-brain axis. Further, gut microbiome has been fou...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-01-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464622004352 |
| _version_ | 1797956214091415552 |
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| author | Nikunj Naliyadhara Aviral Kumar Shailendra Kumar Gangwar Thulsidharan Nair Devanarayanan Mangala Hegde Mohammed S. Alqahtani Mohamed Abbas Gautam Sethi Ajaikumar Kunnumakkara |
| author_facet | Nikunj Naliyadhara Aviral Kumar Shailendra Kumar Gangwar Thulsidharan Nair Devanarayanan Mangala Hegde Mohammed S. Alqahtani Mohamed Abbas Gautam Sethi Ajaikumar Kunnumakkara |
| author_sort | Nikunj Naliyadhara |
| collection | DOAJ |
| description | The human gastrointestinal tract harbors a diverse range of microbial species, which helps to regulate various biological processes such as homeostasis of the gut barrier, stimulation of the immune system, and neurological health benefits from the gut-brain axis. Further, gut microbiome has been found to aid in the uptake of nutrients from food in large intestines. The dietary changes may lead to significant changes in the gut microbial population, which suggest that a positive change can be made in gut microbial diversity by changing the dietary style. The potential dietary substances that can positively enhance the gut microbial populations could be dietary antioxidants, which possess many health benefits in multiple oxidative stress-related diseases such as cardiovascular disease, cancer, diabetes, obesity, etc. Food antioxidants are necessary nutrients required by the human body to balance the oxidative stress generated from various biochemical and metabolic reactions. The interactions between the gut microbiota and antioxidants are vital for maintenance of homeostasis in gut microbiome, as it helps in the diversity of gut bacteria and influences the bioavailability of antioxidants by increasing the production of bioactive metabolites through microbiome. It is evident from different studies that food-derived antioxidants and gut microbial population have an active interaction leading to alleviation of gut microbial dysbiosis. A plethora of clinical studies has found the positive impact of food antioxidants on gut microflora that could aid in developing gut microbe-targeting therapeutics for various diseases. This review discusses the health benefits of major dietary antioxidant groups, and the interaction of gut microbiota with these dietary antioxidants in-depth with various pre-clinical and human dietary interventions. |
| first_indexed | 2024-04-10T23:45:26Z |
| format | Article |
| id | doaj.art-04e18e489610419baa6e43851cc85cf2 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-04-10T23:45:26Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-04e18e489610419baa6e43851cc85cf22023-01-11T04:28:13ZengElsevierJournal of Functional Foods1756-46462023-01-01100105365Interplay of dietary antioxidants and gut microbiome in human health: What has been learnt thus far?Nikunj Naliyadhara0Aviral Kumar1Shailendra Kumar Gangwar2Thulsidharan Nair Devanarayanan3Mangala Hegde4Mohammed S. Alqahtani5Mohamed Abbas6Gautam Sethi7Ajaikumar Kunnumakkara8Cancer Biology Laboratory, Department of Biosciences and Bioengineering, Indian Institute of Technology (IIT) Guwahati, Guwahati, Assam 781039, India; International Joint Program in Food Science and Technology, Department of Chemical Engineering, Indian Institute of Technology (IIT) Guwahati, Guwahati, Assam 781039, IndiaCancer Biology Laboratory, Department of Biosciences and Bioengineering, Indian Institute of Technology (IIT) Guwahati, Guwahati, Assam 781039, IndiaCancer Biology Laboratory, Department of Biosciences and Bioengineering, Indian Institute of Technology (IIT) Guwahati, Guwahati, Assam 781039, IndiaCancer Biology Laboratory, Department of Biosciences and Bioengineering, Indian Institute of Technology (IIT) Guwahati, Guwahati, Assam 781039, IndiaCancer Biology Laboratory, Department of Biosciences and Bioengineering, Indian Institute of Technology (IIT) Guwahati, Guwahati, Assam 781039, IndiaRadiological Sciences Department, College of Applied Medical Sciences, King Khalid University, Abha 61421, Saudi Arabia; BioImaging Unit, Space Research Centre, Michael Atiyah Building, University of Leicester, Leicester LE1 7RH, UKElectrical Engineering Department, College of Engineering, King Khalid University, Abha 61421, Saudi Arabia; Electronics and Communications Department, College of Engineering, Delta University for Science and Technology, Gamasa 35712, EgyptDepartment of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117600, Singapore; Corresponding authors.Cancer Biology Laboratory, Department of Biosciences and Bioengineering, Indian Institute of Technology (IIT) Guwahati, Guwahati, Assam 781039, India; Corresponding authors.The human gastrointestinal tract harbors a diverse range of microbial species, which helps to regulate various biological processes such as homeostasis of the gut barrier, stimulation of the immune system, and neurological health benefits from the gut-brain axis. Further, gut microbiome has been found to aid in the uptake of nutrients from food in large intestines. The dietary changes may lead to significant changes in the gut microbial population, which suggest that a positive change can be made in gut microbial diversity by changing the dietary style. The potential dietary substances that can positively enhance the gut microbial populations could be dietary antioxidants, which possess many health benefits in multiple oxidative stress-related diseases such as cardiovascular disease, cancer, diabetes, obesity, etc. Food antioxidants are necessary nutrients required by the human body to balance the oxidative stress generated from various biochemical and metabolic reactions. The interactions between the gut microbiota and antioxidants are vital for maintenance of homeostasis in gut microbiome, as it helps in the diversity of gut bacteria and influences the bioavailability of antioxidants by increasing the production of bioactive metabolites through microbiome. It is evident from different studies that food-derived antioxidants and gut microbial population have an active interaction leading to alleviation of gut microbial dysbiosis. A plethora of clinical studies has found the positive impact of food antioxidants on gut microflora that could aid in developing gut microbe-targeting therapeutics for various diseases. This review discusses the health benefits of major dietary antioxidant groups, and the interaction of gut microbiota with these dietary antioxidants in-depth with various pre-clinical and human dietary interventions.http://www.sciencedirect.com/science/article/pii/S1756464622004352AntioxidantsGut microbiomeInteractionCarotenoidsPolyphenols |
| spellingShingle | Nikunj Naliyadhara Aviral Kumar Shailendra Kumar Gangwar Thulsidharan Nair Devanarayanan Mangala Hegde Mohammed S. Alqahtani Mohamed Abbas Gautam Sethi Ajaikumar Kunnumakkara Interplay of dietary antioxidants and gut microbiome in human health: What has been learnt thus far? Journal of Functional Foods Antioxidants Gut microbiome Interaction Carotenoids Polyphenols |
| title | Interplay of dietary antioxidants and gut microbiome in human health: What has been learnt thus far? |
| title_full | Interplay of dietary antioxidants and gut microbiome in human health: What has been learnt thus far? |
| title_fullStr | Interplay of dietary antioxidants and gut microbiome in human health: What has been learnt thus far? |
| title_full_unstemmed | Interplay of dietary antioxidants and gut microbiome in human health: What has been learnt thus far? |
| title_short | Interplay of dietary antioxidants and gut microbiome in human health: What has been learnt thus far? |
| title_sort | interplay of dietary antioxidants and gut microbiome in human health what has been learnt thus far |
| topic | Antioxidants Gut microbiome Interaction Carotenoids Polyphenols |
| url | http://www.sciencedirect.com/science/article/pii/S1756464622004352 |
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