Ion Channels as Therapeutic Targets in High Grade Gliomas
Glioblastoma multiforme (GBM) is a lethal brain cancer with an average survival of 14–15 months even with exhaustive treatment. High grade gliomas (HGG) represent the leading cause of CNS cancer-related death in children and adults due to the aggressive nature of the tumour and limited treatment opt...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-10-01
|
| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/12/10/3068 |
| _version_ | 1797550288714858496 |
|---|---|
| author | Michaela Griffin Raheela Khan Surajit Basu Stuart Smith |
| author_facet | Michaela Griffin Raheela Khan Surajit Basu Stuart Smith |
| author_sort | Michaela Griffin |
| collection | DOAJ |
| description | Glioblastoma multiforme (GBM) is a lethal brain cancer with an average survival of 14–15 months even with exhaustive treatment. High grade gliomas (HGG) represent the leading cause of CNS cancer-related death in children and adults due to the aggressive nature of the tumour and limited treatment options. The scarcity of treatment available for GBM has opened the field to new modalities such as electrotherapy. Previous studies have identified the clinical benefit of electrotherapy in combination with chemotherapeutics, however the mechanistic action is unclear. Increasing evidence indicates that not only are ion channels key in regulating electrical signaling and membrane potential of excitable cells, they perform a crucial role in the development and neoplastic progression of brain tumours. Unlike other tissue types, neural tissue is intrinsically electrically active and reliant on ion channels and their function. Ion channels are essential in cell cycle control, invasion and migration of cancer cells and therefore present as valuable therapeutic targets. This review aims to discuss the role that ion channels hold in gliomagenesis and whether we can target and exploit these channels to provide new therapeutic targets and whether ion channels hold the mechanistic key to the newfound success of electrotherapies. |
| first_indexed | 2024-03-10T15:27:10Z |
| format | Article |
| id | doaj.art-04e27e2218b8413da9ebf90ac279d8c1 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T15:27:10Z |
| publishDate | 2020-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-04e27e2218b8413da9ebf90ac279d8c12023-11-20T17:54:37ZengMDPI AGCancers2072-66942020-10-011210306810.3390/cancers12103068Ion Channels as Therapeutic Targets in High Grade GliomasMichaela Griffin0Raheela Khan1Surajit Basu2Stuart Smith3Children’s Brain Tumour Research Centre, Biodiscovery Institute, University of Nottingham, Nottingham NG7 2RD, UKDivision of Medical Sciences and Graduate Entry Medicine, Royal Derby Hospital, University of Nottingham, Nottingham NG7 2RD, UKDepartment of Neurosurgery, Queen’s Medical Centre, Nottingham University Hospitals, Nottingham NG7 2RD, UKChildren’s Brain Tumour Research Centre, Biodiscovery Institute, University of Nottingham, Nottingham NG7 2RD, UKGlioblastoma multiforme (GBM) is a lethal brain cancer with an average survival of 14–15 months even with exhaustive treatment. High grade gliomas (HGG) represent the leading cause of CNS cancer-related death in children and adults due to the aggressive nature of the tumour and limited treatment options. The scarcity of treatment available for GBM has opened the field to new modalities such as electrotherapy. Previous studies have identified the clinical benefit of electrotherapy in combination with chemotherapeutics, however the mechanistic action is unclear. Increasing evidence indicates that not only are ion channels key in regulating electrical signaling and membrane potential of excitable cells, they perform a crucial role in the development and neoplastic progression of brain tumours. Unlike other tissue types, neural tissue is intrinsically electrically active and reliant on ion channels and their function. Ion channels are essential in cell cycle control, invasion and migration of cancer cells and therefore present as valuable therapeutic targets. This review aims to discuss the role that ion channels hold in gliomagenesis and whether we can target and exploit these channels to provide new therapeutic targets and whether ion channels hold the mechanistic key to the newfound success of electrotherapies.https://www.mdpi.com/2072-6694/12/10/3068ion channelglioblastoma multiformeion channel inhibitormembrane potentialglioma |
| spellingShingle | Michaela Griffin Raheela Khan Surajit Basu Stuart Smith Ion Channels as Therapeutic Targets in High Grade Gliomas Cancers ion channel glioblastoma multiforme ion channel inhibitor membrane potential glioma |
| title | Ion Channels as Therapeutic Targets in High Grade Gliomas |
| title_full | Ion Channels as Therapeutic Targets in High Grade Gliomas |
| title_fullStr | Ion Channels as Therapeutic Targets in High Grade Gliomas |
| title_full_unstemmed | Ion Channels as Therapeutic Targets in High Grade Gliomas |
| title_short | Ion Channels as Therapeutic Targets in High Grade Gliomas |
| title_sort | ion channels as therapeutic targets in high grade gliomas |
| topic | ion channel glioblastoma multiforme ion channel inhibitor membrane potential glioma |
| url | https://www.mdpi.com/2072-6694/12/10/3068 |
| work_keys_str_mv | AT michaelagriffin ionchannelsastherapeutictargetsinhighgradegliomas AT raheelakhan ionchannelsastherapeutictargetsinhighgradegliomas AT surajitbasu ionchannelsastherapeutictargetsinhighgradegliomas AT stuartsmith ionchannelsastherapeutictargetsinhighgradegliomas |