The Use of Baikal Psychrophilic Actinobacteria for Synthesis of Biologically Active Natural Products from Sawdust Waste
One of the relevant areas in microbiology and biotechnology is the study of microorganisms that induce the destruction of different materials, buildings, and machines and lead to negative effects. At the same time, the positive ecological effects of degradation can be explained by the detoxication o...
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| Format: | Article |
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MDPI AG
2022-05-01
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| Series: | Fermentation |
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| Online Access: | https://www.mdpi.com/2311-5637/8/5/213 |
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| author | Ekaterina V. Pereliaeva Maria E. Dmitrieva Maria M. Morgunova Alexander Y. Belyshenko Natalia A. Imidoeva Alexander S. Ostyak Denis V. Axenov-Gribanov |
| author_facet | Ekaterina V. Pereliaeva Maria E. Dmitrieva Maria M. Morgunova Alexander Y. Belyshenko Natalia A. Imidoeva Alexander S. Ostyak Denis V. Axenov-Gribanov |
| author_sort | Ekaterina V. Pereliaeva |
| collection | DOAJ |
| description | One of the relevant areas in microbiology and biotechnology is the study of microorganisms that induce the destruction of different materials, buildings, and machines and lead to negative effects. At the same time, the positive ecological effects of degradation can be explained by the detoxication of industrial and agricultural wastes, chemical substances, petroleum products, xenobiotics, pesticides, and other chemical pollutants. Many of these industrial wastes include hard-to-degrade components, such as lignocellulose or plastics. The biosynthesis of natural products based on the transformation of lignocellulosic wastes is of particular interest. One of the world’s unique ecosystems is presented by Lake Baikal. This ecosystem is characterized by the highest level of biodiversity, low temperatures, and a high purity of the water. Here, we studied the ability of several psychrophilic representatives of Baikal Actinobacteria to grow on sawdust wastes and transform them into bioactive natural products. Different strains of both widely spread genus of Actinobacteria and rare genera of Actinobacteria were tested. We used the LC-MS methods to show that Actinobacteria living in sawmill wastes can produce both known and novel natural products with antibiotic activity. We demonstrated that the type of sawmill wastes and their concentration influence the Actinobacteria biosynthetic potential. We have shown for the first time that the use of Baikal psychrophilic microorganisms as a factory for biodegradation is applicable for the transformation of lignocellulosic wastes. Thus, the development of techniques for screening novel natural products leads to an elaboration on the active ingredients for novel drugs. |
| first_indexed | 2024-03-10T03:54:45Z |
| format | Article |
| id | doaj.art-04e3911e45a248148f4206944c672e1b |
| institution | Directory Open Access Journal |
| issn | 2311-5637 |
| language | English |
| last_indexed | 2024-03-10T03:54:45Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Fermentation |
| spelling | doaj.art-04e3911e45a248148f4206944c672e1b2023-11-23T10:57:04ZengMDPI AGFermentation2311-56372022-05-018521310.3390/fermentation8050213The Use of Baikal Psychrophilic Actinobacteria for Synthesis of Biologically Active Natural Products from Sawdust WasteEkaterina V. Pereliaeva0Maria E. Dmitrieva1Maria M. Morgunova2Alexander Y. Belyshenko3Natalia A. Imidoeva4Alexander S. Ostyak5Denis V. Axenov-Gribanov6Laboratory of Experimental Neurophysiology, Department of Research and Development, Biological Faculty, Irkutsk State University, 664003 Irkutsk, RussiaLaboratory of Experimental Neurophysiology, Department of Research and Development, Biological Faculty, Irkutsk State University, 664003 Irkutsk, RussiaLaboratory of Experimental Neurophysiology, Department of Research and Development, Biological Faculty, Irkutsk State University, 664003 Irkutsk, RussiaLaboratory of Experimental Neurophysiology, Department of Research and Development, Biological Faculty, Irkutsk State University, 664003 Irkutsk, RussiaLaboratory of Experimental Neurophysiology, Department of Research and Development, Biological Faculty, Irkutsk State University, 664003 Irkutsk, RussiaDepartment of Research and Development, Irkutsk Antiplague Research Institute of Siberia and Far East of the Federal Service for Surveillance in the Sphere of Consumers’ Rights Protection and Human Welfare, 664047 Irkutsk, RussiaLaboratory of Experimental Neurophysiology, Department of Research and Development, Biological Faculty, Irkutsk State University, 664003 Irkutsk, RussiaOne of the relevant areas in microbiology and biotechnology is the study of microorganisms that induce the destruction of different materials, buildings, and machines and lead to negative effects. At the same time, the positive ecological effects of degradation can be explained by the detoxication of industrial and agricultural wastes, chemical substances, petroleum products, xenobiotics, pesticides, and other chemical pollutants. Many of these industrial wastes include hard-to-degrade components, such as lignocellulose or plastics. The biosynthesis of natural products based on the transformation of lignocellulosic wastes is of particular interest. One of the world’s unique ecosystems is presented by Lake Baikal. This ecosystem is characterized by the highest level of biodiversity, low temperatures, and a high purity of the water. Here, we studied the ability of several psychrophilic representatives of Baikal Actinobacteria to grow on sawdust wastes and transform them into bioactive natural products. Different strains of both widely spread genus of Actinobacteria and rare genera of Actinobacteria were tested. We used the LC-MS methods to show that Actinobacteria living in sawmill wastes can produce both known and novel natural products with antibiotic activity. We demonstrated that the type of sawmill wastes and their concentration influence the Actinobacteria biosynthetic potential. We have shown for the first time that the use of Baikal psychrophilic microorganisms as a factory for biodegradation is applicable for the transformation of lignocellulosic wastes. Thus, the development of techniques for screening novel natural products leads to an elaboration on the active ingredients for novel drugs.https://www.mdpi.com/2311-5637/8/5/213actinobacteriaLake Baikalbiodestructionsawmill wastenatural productsantibiotic activity |
| spellingShingle | Ekaterina V. Pereliaeva Maria E. Dmitrieva Maria M. Morgunova Alexander Y. Belyshenko Natalia A. Imidoeva Alexander S. Ostyak Denis V. Axenov-Gribanov The Use of Baikal Psychrophilic Actinobacteria for Synthesis of Biologically Active Natural Products from Sawdust Waste Fermentation actinobacteria Lake Baikal biodestruction sawmill waste natural products antibiotic activity |
| title | The Use of Baikal Psychrophilic Actinobacteria for Synthesis of Biologically Active Natural Products from Sawdust Waste |
| title_full | The Use of Baikal Psychrophilic Actinobacteria for Synthesis of Biologically Active Natural Products from Sawdust Waste |
| title_fullStr | The Use of Baikal Psychrophilic Actinobacteria for Synthesis of Biologically Active Natural Products from Sawdust Waste |
| title_full_unstemmed | The Use of Baikal Psychrophilic Actinobacteria for Synthesis of Biologically Active Natural Products from Sawdust Waste |
| title_short | The Use of Baikal Psychrophilic Actinobacteria for Synthesis of Biologically Active Natural Products from Sawdust Waste |
| title_sort | use of baikal psychrophilic actinobacteria for synthesis of biologically active natural products from sawdust waste |
| topic | actinobacteria Lake Baikal biodestruction sawmill waste natural products antibiotic activity |
| url | https://www.mdpi.com/2311-5637/8/5/213 |
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