Point on the Aortic Bicuspid Valve
Background—Bicuspid aortic valve (BAV) disease is the most prevalent congenital heart disease in the world. Knowledge about its subtypes origin, development, and evolution is poor despite the frequency and the potential gravity of this condition. Its prognosis mostly depends on the risk of aortic an...
Main Authors: | , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2022-03-01
|
Series: | Life |
Subjects: | |
Online Access: | https://www.mdpi.com/2075-1729/12/4/518 |
_version_ | 1797410397291020288 |
---|---|
author | Chloé Bernard Marie Catherine Morgant David Guillier Nicolas Cheynel Olivier Bouchot |
author_facet | Chloé Bernard Marie Catherine Morgant David Guillier Nicolas Cheynel Olivier Bouchot |
author_sort | Chloé Bernard |
collection | DOAJ |
description | Background—Bicuspid aortic valve (BAV) disease is the most prevalent congenital heart disease in the world. Knowledge about its subtypes origin, development, and evolution is poor despite the frequency and the potential gravity of this condition. Its prognosis mostly depends on the risk of aortic aneurysm development with an increased risk of aortic dissection. Aims—This review aims to describe this complex pathology in way to improve the bicuspid patients’ management. Study design—We reviewed the literature with MEDLINE and EMBASE databases using MeSH terms such as “bicuspid aortic valve”, “ascending aorta”, and “bicuspid classification”. Results—There are various classifications. They depend on the criteria chosen by the authors to differentiate subtypes. Those criteria can be the number and position of the raphes, the cusps, the commissures, or their arrangements regarding coronary ostia. Sievers’ classification is the reference. The phenotypic description of embryology revealed that all subtypes of BAV are the results of different embryological pathogenesis, and therefore, should be considered as distinct conditions. Their common development towards aortic dilatation is explained by the aortic media’s pathological histology with cystic medial necrosis. At the opposite, BAV seems to display a profound genetic heterogeneity with both sporadic and familial forms. BAV can be even isolated or combined with other congenital malformations. Conclusions—All those characteristics make this pathology a highly complex condition that needs further genetic, embryological, and hemodynamic explorations to complete its well described anatomy. |
first_indexed | 2024-03-09T04:29:22Z |
format | Article |
id | doaj.art-04e462ad167d43bf83a6d6eeab9f208e |
institution | Directory Open Access Journal |
issn | 2075-1729 |
language | English |
last_indexed | 2024-03-09T04:29:22Z |
publishDate | 2022-03-01 |
publisher | MDPI AG |
record_format | Article |
series | Life |
spelling | doaj.art-04e462ad167d43bf83a6d6eeab9f208e2023-12-03T13:36:59ZengMDPI AGLife2075-17292022-03-0112451810.3390/life12040518Point on the Aortic Bicuspid ValveChloé Bernard0Marie Catherine Morgant1David Guillier2Nicolas Cheynel3Olivier Bouchot4Department of Anatomy, University of Burgundy Medical School, 21000 Dijon, FranceDepartment of Anatomy, University of Burgundy Medical School, 21000 Dijon, FranceDepartment of Anatomy, University of Burgundy Medical School, 21000 Dijon, FranceDepartment of Anatomy, University of Burgundy Medical School, 21000 Dijon, FranceDepartment of Cardiovascular and Thoracic Surgery, Dijon University Hospital, 21000 Dijon, FranceBackground—Bicuspid aortic valve (BAV) disease is the most prevalent congenital heart disease in the world. Knowledge about its subtypes origin, development, and evolution is poor despite the frequency and the potential gravity of this condition. Its prognosis mostly depends on the risk of aortic aneurysm development with an increased risk of aortic dissection. Aims—This review aims to describe this complex pathology in way to improve the bicuspid patients’ management. Study design—We reviewed the literature with MEDLINE and EMBASE databases using MeSH terms such as “bicuspid aortic valve”, “ascending aorta”, and “bicuspid classification”. Results—There are various classifications. They depend on the criteria chosen by the authors to differentiate subtypes. Those criteria can be the number and position of the raphes, the cusps, the commissures, or their arrangements regarding coronary ostia. Sievers’ classification is the reference. The phenotypic description of embryology revealed that all subtypes of BAV are the results of different embryological pathogenesis, and therefore, should be considered as distinct conditions. Their common development towards aortic dilatation is explained by the aortic media’s pathological histology with cystic medial necrosis. At the opposite, BAV seems to display a profound genetic heterogeneity with both sporadic and familial forms. BAV can be even isolated or combined with other congenital malformations. Conclusions—All those characteristics make this pathology a highly complex condition that needs further genetic, embryological, and hemodynamic explorations to complete its well described anatomy.https://www.mdpi.com/2075-1729/12/4/518bicuspid aortic valveSiever’s classificationgeneticshistologyaortic aneurism |
spellingShingle | Chloé Bernard Marie Catherine Morgant David Guillier Nicolas Cheynel Olivier Bouchot Point on the Aortic Bicuspid Valve Life bicuspid aortic valve Siever’s classification genetics histology aortic aneurism |
title | Point on the Aortic Bicuspid Valve |
title_full | Point on the Aortic Bicuspid Valve |
title_fullStr | Point on the Aortic Bicuspid Valve |
title_full_unstemmed | Point on the Aortic Bicuspid Valve |
title_short | Point on the Aortic Bicuspid Valve |
title_sort | point on the aortic bicuspid valve |
topic | bicuspid aortic valve Siever’s classification genetics histology aortic aneurism |
url | https://www.mdpi.com/2075-1729/12/4/518 |
work_keys_str_mv | AT chloebernard pointontheaorticbicuspidvalve AT mariecatherinemorgant pointontheaorticbicuspidvalve AT davidguillier pointontheaorticbicuspidvalve AT nicolascheynel pointontheaorticbicuspidvalve AT olivierbouchot pointontheaorticbicuspidvalve |