Site-Specific Differences in Bone Mineral Density of Proximal Femur Correlate with the Type of Hip Fracture
The aim of this study was to investigate whether site-specific differences in bone mineral density (BMD) of proximal femur correlate with the type of hip fracture using quantitative computed tomography. Femoral neck (FN) fractures were classified as nondisplaced or displaced subtypes. Intertrochante...
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| Format: | Article |
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MDPI AG
2023-05-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/13/11/1877 |
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| author | Ning Li Yi Yuan Lu Yin Minghui Yang Yandong Liu Wenshuang Zhang Kangkang Ma Fengyun Zhou Zitong Cheng Ling Wang Xiaoguang Cheng |
| author_facet | Ning Li Yi Yuan Lu Yin Minghui Yang Yandong Liu Wenshuang Zhang Kangkang Ma Fengyun Zhou Zitong Cheng Ling Wang Xiaoguang Cheng |
| author_sort | Ning Li |
| collection | DOAJ |
| description | The aim of this study was to investigate whether site-specific differences in bone mineral density (BMD) of proximal femur correlate with the type of hip fracture using quantitative computed tomography. Femoral neck (FN) fractures were classified as nondisplaced or displaced subtypes. Intertrochanteric (IT) fractures were classified as A1, A2, or A3. The severe hip fractures were identified as displaced FN fractures or unstable IT fractures (A2 and A3). In total, 404 FN fractures (89 nondisplaced and 317 displaced) and 189 IT fractures (76 A1, 90 A2, and 23 A3) were enrolled. Areal BMD (aBMD) and volumetric BMD (vBMD) were measured in the regions of total hip (TH), trochanter (TR), FN, and IT of the contralateral unfractured femur. IT fractures exhibited lower BMD than FN fractures (all <i>p</i> ≤ 0.01). However, unstable IT fractures had higher BMD compared with stable ones (<i>p</i> < 0.01). After adjusting for covariates, higher BMD in TH and IT were associated with IT A2 (A1 vs. A2: odds ratios (ORs) from 1.47 to 1.69, all <i>p</i> < 0.01). Low bone measurements were risk factors for stable IT fractures (IT A1 vs. FN fracture subtypes: ORs from 0.40 to 0.65, all <i>p</i> < 0.01). There are substantial site-specific differences in BMD between IT fractures A1 and displaced FN fractures. Higher bone density was associated with unstable IT fracture when compared with stable ones. The understanding of biomechanics of various fracture types could help to improve the clinical management of these patients. |
| first_indexed | 2024-03-11T03:09:12Z |
| format | Article |
| id | doaj.art-04e6cf8d465b49518898456ceef2b936 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-11T03:09:12Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-04e6cf8d465b49518898456ceef2b9362023-11-18T07:42:20ZengMDPI AGDiagnostics2075-44182023-05-011311187710.3390/diagnostics13111877Site-Specific Differences in Bone Mineral Density of Proximal Femur Correlate with the Type of Hip FractureNing Li0Yi Yuan1Lu Yin2Minghui Yang3Yandong Liu4Wenshuang Zhang5Kangkang Ma6Fengyun Zhou7Zitong Cheng8Ling Wang9Xiaoguang Cheng10Department of Traumatic Orthopedics, Beijing Jishuitan Hospital, Beijing 100035, ChinaDepartment of Radiology, Beijing Jishuitan Hospital, Beijing 100035, ChinaMedical Research and Biometrics Center, National Center for Cardiovascular Disease, Beijing 100037, ChinaDepartment of Traumatic Orthopedics, Beijing Jishuitan Hospital, Beijing 100035, ChinaDepartment of Radiology, Beijing Jishuitan Hospital, Beijing 100035, ChinaDepartment of Radiology, Beijing Jishuitan Hospital, Beijing 100035, ChinaDepartment of Radiology, Beijing Jishuitan Hospital, Beijing 100035, ChinaDepartment of Radiology, Beijing Jishuitan Hospital, Beijing 100035, ChinaDepartment of Radiology, Beijing Jishuitan Hospital, Beijing 100035, ChinaDepartment of Radiology, Beijing Jishuitan Hospital, Beijing 100035, ChinaDepartment of Radiology, Beijing Jishuitan Hospital, Beijing 100035, ChinaThe aim of this study was to investigate whether site-specific differences in bone mineral density (BMD) of proximal femur correlate with the type of hip fracture using quantitative computed tomography. Femoral neck (FN) fractures were classified as nondisplaced or displaced subtypes. Intertrochanteric (IT) fractures were classified as A1, A2, or A3. The severe hip fractures were identified as displaced FN fractures or unstable IT fractures (A2 and A3). In total, 404 FN fractures (89 nondisplaced and 317 displaced) and 189 IT fractures (76 A1, 90 A2, and 23 A3) were enrolled. Areal BMD (aBMD) and volumetric BMD (vBMD) were measured in the regions of total hip (TH), trochanter (TR), FN, and IT of the contralateral unfractured femur. IT fractures exhibited lower BMD than FN fractures (all <i>p</i> ≤ 0.01). However, unstable IT fractures had higher BMD compared with stable ones (<i>p</i> < 0.01). After adjusting for covariates, higher BMD in TH and IT were associated with IT A2 (A1 vs. A2: odds ratios (ORs) from 1.47 to 1.69, all <i>p</i> < 0.01). Low bone measurements were risk factors for stable IT fractures (IT A1 vs. FN fracture subtypes: ORs from 0.40 to 0.65, all <i>p</i> < 0.01). There are substantial site-specific differences in BMD between IT fractures A1 and displaced FN fractures. Higher bone density was associated with unstable IT fracture when compared with stable ones. The understanding of biomechanics of various fracture types could help to improve the clinical management of these patients.https://www.mdpi.com/2075-4418/13/11/1877hip fracturefemoral neck fractureintertrochanteric fracturebone mineral densityquantitative computed tomography |
| spellingShingle | Ning Li Yi Yuan Lu Yin Minghui Yang Yandong Liu Wenshuang Zhang Kangkang Ma Fengyun Zhou Zitong Cheng Ling Wang Xiaoguang Cheng Site-Specific Differences in Bone Mineral Density of Proximal Femur Correlate with the Type of Hip Fracture Diagnostics hip fracture femoral neck fracture intertrochanteric fracture bone mineral density quantitative computed tomography |
| title | Site-Specific Differences in Bone Mineral Density of Proximal Femur Correlate with the Type of Hip Fracture |
| title_full | Site-Specific Differences in Bone Mineral Density of Proximal Femur Correlate with the Type of Hip Fracture |
| title_fullStr | Site-Specific Differences in Bone Mineral Density of Proximal Femur Correlate with the Type of Hip Fracture |
| title_full_unstemmed | Site-Specific Differences in Bone Mineral Density of Proximal Femur Correlate with the Type of Hip Fracture |
| title_short | Site-Specific Differences in Bone Mineral Density of Proximal Femur Correlate with the Type of Hip Fracture |
| title_sort | site specific differences in bone mineral density of proximal femur correlate with the type of hip fracture |
| topic | hip fracture femoral neck fracture intertrochanteric fracture bone mineral density quantitative computed tomography |
| url | https://www.mdpi.com/2075-4418/13/11/1877 |
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